Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 31, 2022
Abstract
Cancer
immunotherapy
has
shown
promising
therapeutic
results
in
the
clinic,
albeit
only
a
limited
number
of
cancer
types,
and
its
efficacy
remains
less
than
satisfactory.
Nanoparticle-based
approaches
have
been
to
increase
response
immunotherapies
address
this
limitation.
In
particular,
magnetic
nanoparticles
(MNPs)
as
powerful
manipulator
are
an
appealing
option
for
comprehensively
regulating
immune
system
vivo
due
their
unique
magnetically
responsive
properties
high
biocompatibility.
This
review
focuses
on
assessing
potential
applications
MNPs
enhancing
tumor
accumulation
immunotherapeutic
agents
immunogenicity,
improving
cell
infiltration,
creating
immunotherapy-sensitive
environment.
We
summarize
recent
progress
application
MNP-based
manipulators
augment
immunotherapy,
by
multiple
effects
under
different
types
external
field.
Furthermore,
we
highlight
mechanisms
underlying
promotion
antitumor
immunity,
including
actuated
delivery
controlled
release
agents,
tracking
visualization
real
time,
regulation
innate/adaptive
cells.
Finally,
consider
perspectives
challenges
immunotherapy.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2234 - 2234
Опубликована: Март 1, 2025
Exosomes
are
nanosized
extracellular
vesicles
secreted
by
various
cells,
including
natural
killer
(NK)
and
known
for
their
low
toxicity,
high
permeability,
biocompatibility,
strong
targeting
ability.
NK
cell-derived
exosomes
(NK-exos)
contain
cytotoxic
proteins
that
enhance
tumor-targeting
efficiency,
making
them
suitable
treating
solid
tumors
such
as
hepatocellular
carcinoma
(HCC).
Despite
potential
in
drug
delivery,
the
mechanisms
of
drug-loaded
NK-exos,
particularly
those
loaded
with
doxorubicin
(NK-exos-Dox),
remain
unclear
HCC.
This
study
explored
anti-tumor
effects
NK-exos-Dox
against
Hep3B
cells
vitro.
expressed
exosome
markers
(CD9
CD63)
(granzyme
B
perforin)
measured
170-220
nm
size.
Compared
to
enhanced
cytotoxicity
apoptosis
upregulating
pro-apoptotic
(Bax,
cytochrome
c,
cleaved
caspase
3,
PARP)
inhibiting
anti-apoptotic
protein
(Bcl-2).
These
findings
suggest
significantly
boost
activating
specific
molecules,
offering
promising
therapeutic
opportunities
tumor
treatment,
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(3)
Опубликована: Март 1, 2025
ABSTRACT
Traditional
chemotherapeutic
approaches
for
cancer
treatment
often
face
challenges,
such
as
limited
bioavailability
and
efficacy
of
anticancer
drugs
due
to
a
lack
specificity
quick
metabolism.
In
this
study,
nanocomposite
hydrogel,
namely
pectin‐
graft
‐poly(4‐acryloylmorpholine‐
co
‐2‐acrylamido‐2‐methyl‐1‐propanesulphonic
acid)
embedded
with
silver
nanoparticles
(Pec‐
g
‐poly(AcM‐
‐AMPS)‐SNPs)
was
developed
dual
drug
delivery
system
treatment.
The
the
neat
gel
without
(SNPs)
were
characterized
using
various
techniques
evaluated
their
efficiencies
co‐delivery
5‐fluorouracil
(5‐FU)
doxorubicin
(DOX)
model
drugs.
exhibited
pH‐responsive
swelling
behavior,
comparatively
higher
observed
nanocomposite,
maximum
at
pH
7.4.
process
obeyed
pseudo‐second‐order
kinetic
model.
A
similar
observation
made
regarding
release
drugs,
significantly
About
83.9%
5‐FU
73.3%
DOX
released
from
7.4
during
8
h.
profile
adhered
first‐order
Higuchi‐square
root
models.
transport
incorporated
out
matrix
into
dissolution
medium
be
Fickian
diffusion
process.
has
been
proven
cytocompatible,
demonstrated
by
cytotoxicity
study
carried
MCF‐10A
cells,
suggesting
its
suitability
oral
combating
cancer.
