Molecular Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Lung
cancer
is
the
leading
cause
of
death
globally,
with
non‐small
cell
lung
accounting
for
majority
(85%)
cases.
Standard
treatments
including
chemotherapy
and
radiotherapy
present
multiple
adverse
effects.
Medicinal
plants,
used
centuries,
are
traditionally
processed
by
methods
such
as
boiling
oral
ingestion,
However,
water
solubility,
absorption,
hepatic
metabolism
reduce
phytoceutical
bioavailability.
More
recently,
isolated
molecular
compounds
from
these
plants
can
be
extracted
phytoceuticals
administered
either
individually
or
an
adjunct
standard
therapy.
Phytoceuticals
have
been
shown
to
alleviate
symptoms,
may
dosage
and,
in
some
cases,
enhance
pharmaceutical
mechanisms.
Research
has
identified
many
phytoceuticals'
actions
on
cancer‐associated
pathways,
oncogenesis,
tumour
microenvironment,
proliferation,
metastasis,
apoptosis.
The
development
novel
nanoparticle
delivery
systems
solid
lipid
nanoparticles,
liquid
crystalline
liposomes
enhanced
bioavailability
targeted
pharmaceuticals
phytoceuticals.
This
review
explores
biological
pathways
associated
cancer,
a
diverse
range
phytoceuticals,
they
act
upon,
pros
cons
several
systems.
Pharmaceutical Development and Technology,
Год журнала:
2022,
Номер
27(5), С. 525 - 544
Опубликована: Май 28, 2022
The
bioavailability
of
drugs
is
dependent
on
several
factors
such
as
solubility
and
the
administration
route.
A
drug
with
poor
aqueous
solubility,
therefore,
poses
challenges
regards
to
its
pharmaceutical
advance
ultimately
biological
usage.
Lipid
nanoparticles
have
been
used
in
science
due
their
importance
green
chemistry.
Their
biochemical
properties
‘green’
materials
processes
mean
they
can
be
environmentally
sustainable.
Generally,
lipid
employed
carriers
for
both
lipophilic
hydrophilic
drugs.
proposed
route
present
advantages
disadvantages
which
should
considered
by
a
formulator.
Solid
(SLNs)
nanostructured
(NLCs)
are
attractive
delivery
systems
because
ease
manufacture,
biocompatibility,
biodegradability,
scale-up
capacity
formulation
constituents.
easy
simple
scalability
novel
SLNs
nano
carriers,
along
various
processing
procedures,
recent
developments,
limitation
toxicity,
optimization
approaches
manufacture
nanoparticles,
lyophilization
release
comprehensively
discussed
this
review.
This
review
also
summarizes
research
data
related
preparation
methods
excipients
NLCs
years.
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
14(10), С. 2845 - 2916
Опубликована: Июль 13, 2024
Abstract
Several
efforts
have
been
extensively
accomplished
for
the
amelioration
of
cancer
treatments
using
different
types
new
drugs
and
less
invasives
therapies
in
comparison
with
traditional
therapeutic
modalities,
which
are
widely
associated
numerous
drawbacks,
such
as
drug
resistance,
non-selectivity
high
costs,
restraining
their
clinical
response.
The
application
natural
compounds
prevention
treatment
cells
has
attracted
significant
attention
from
pharmaceuticals
scientific
communities
over
past
decades.
Although
use
nanotechnology
therapy
is
still
preliminary
stages,
nanotherapeutics
demonstrated
to
decrease
various
limitations
related
compounds,
physical/chemical
instability,
poor
aqueous
solubility,
low
bioavailability.
Despite
emerged
a
promise
improve
bioavailability
there
limited
trials
performed
challenges
required
pre-clinical
trials,
production
at
an
industrial
level,
assurance
long-term
stability,
physiological
barriers
safety
regulatory
issues.
This
review
highlights
most
recent
advances
nanocarriers
secreted
plants,
bacteria,
fungi,
marine
organisms,
well
role
on
cell
signaling
pathways
anticancer
treatments.
Additionally,
status
main
regarding
loaded
applications
were
also
discussed.
Graphical
abstract
Biomedicines,
Год журнала:
2023,
Номер
11(2), С. 473 - 473
Опубликована: Фев. 6, 2023
On
a
global
scale,
lung
cancer
is
acknowledged
to
be
the
major
driver
of
death
attributable
treatment
challenges
and
poor
prognosis.
Classical
regimens,
such
as
chemotherapy
or
radiotherapy,
can
used
treat
cancer,
but
appended
adverse
effects
limit
them.
Because
numerous
side
associated
with
these
modalities,
it
crucial
strive
develop
novel
better
strategies
for
managing
cancer.
Attributes
enhanced
bioavailability,
in
vivo
stability,
intestinal
absorption
pattern,
solubility,
prolonged
targeted
distribution,
superior
therapeutic
effectiveness
anticancer
drugs
have
all
been
boosted
emergence
nano-based
systems.
Lipid-based
polymeric
inorganic
nano-formulations
are
now
being
explored
delivery
chemotherapeutics
treatment.
Nano-based
approaches
pioneering
route
primary
metastatic
diagnosis
The
implementation
development
innovative
nanocarriers
drug
administration,
particularly
developing
therapies,
an
intriguing
challenging
task
scientific
domain.
current
article
provides
overview
methods,
passive
active
targeting
Combinatorial
therapy
techniques
overcome
resistance
cells,
potential
ways
increase
effectiveness,
also
discussed.
In
addition,
clinical
studies
therapies
at
different
stages
presented.
A
summary
patent
literature
has
included
keep
readers
aware
new
nanotechnology-based
Advanced Therapeutics,
Год журнала:
2023,
Номер
6(12)
Опубликована: Сен. 12, 2023
Abstract
Lung
cancer
remains
the
leading
cause
of
cancer‐related
deaths
worldwide,
and
conventional
treatments
for
disease
often
fall
short.
Smart
nanoparticles
(NPs)
are
emerging
as
a
promising
strategy
treatment
lung
cancer,
owing
to
their
ability
selectively
deliver
therapeutic
agents
cells
while
minimizing
off‐target
effects.
NPs
can
respond
specific
stimuli
such
changes
in
pH,
temperature,
or
enzymes,
allowing
them
release
cargo
only
when
triggered.
Among
various
types
smart
NPs,
lipid‐based
including
liposomes,
solid
lipid
nanoparticles,
cubosomes,
extracellular
vesicles,
have
garnered
highest
interest
due
biocompatibility,
low
toxicity,
versatility
encapsulating
wide
variety
drugs
genetic
material.
This
review
discusses
current
status
treatment,
recent
advances
targeting
strategies,
stimuli‐responsive
combination
therapies.
The
challenges
opportunities
associated
with
translating
into
clinical
applications
also
discussed.
highlights
potential
revolutionize
improve
patient
outcomes.
Microorganisms,
Год журнала:
2022,
Номер
10(11), С. 2206 - 2206
Опубликована: Ноя. 8, 2022
Microorganisms
have
long
been
known
to
play
key
roles
in
the
initiation
and
development
of
tumors.
The
oral
microbiota
tumorigenesis
linked
epidemiological
research
relating
molecular
pathology.
Notably,
some
bacteria
can
impact
distal
tumors
by
their
gastrointestinal
or
blood-borne
transmission
under
pathological
circumstances.
Certain
drive
progression
through
direct
indirect
immune
system
actions.
This
review
systemically
discusses
recent
advances
field
microecology
tumor,
including
oncogenic
role
microbial
abnormalities
various
potential
carcinogenesis
mechanisms
(excessive
inflammatory
response,
host
immunosuppression,
anti-apoptotic
activity,
carcinogen
secretion)
introduce
future
directions
for
effective
tumor
prevention.
ACS Applied Bio Materials,
Год журнала:
2023,
Номер
6(7), С. 2747 - 2759
Опубликована: Июнь 29, 2023
A
design
has
been
established
for
the
surface
decoration
of
superparamagnetic
iron
oxide
nanoparticles
(SPIONs)
with
anti-vascular
endothelial
growth
factor
peptide,
HRH,
to
formulate
a
targeted
paclitaxel
(PTX)
delivery
nanosystem
notable
tumor
targetability
and
antiangiogenic
activity.
The
methodology
included
(i)
tandem
functionalization
via
coupling
reactions,
(ii)
pertinent
physicochemical
characterization,
(iii)
in
vitro
assessment
drug
release,
anti-proliferative
activity,
quantification
vascular
(VEGF-A)
levels,
(iv)
vivo
testing
using
lung
xenograft
mouse
model.
Formulated
CLA-coated
PTX-SPIONs@HRH
depicted
size
charge
108.5
±
3.5
nm
−30.4
2.3
mV,
respectively,
quasi-spherical
shape
relative
pristine
SPIONs.
Fourier
transform
infrared
(FTIR)
analysis
estimation
free
carboxylic
groups
supported
preparation
PTX-SPIONs@HRH.
exhibited
high
PTX
loading
efficiency
(98.5%)
sustained
release
vitro,
marked
dose
dependent
activity
A549
adenocarcinoma
cells,
complimented
by
an
enhanced
cellular
uptake.
significantly
reduced
secretion
levels
VEGF-A
human
dermal
microvascular
cells
from
46.9
35.6
pg/mL
compared
untreated
control.
76.6%
regression
was
recorded
model
following
intervention
PTX-SPIONs@HRH,
demonstrating
angiogenesis
inhibition.
half-life
almost
2-folds
demonstrated
prolonged
plasma
circulation
time
subcutaneous
injection
(SC).
Thus,
it
is
suggested
that
could
provide
potential
effective
treatment
modality
non-small-cell
carcinoma
as
nanomedicine.
Pharmaceutical Development and Technology,
Год журнала:
2024,
Номер
unknown, С. 1 - 17
Опубликована: Окт. 11, 2024
Traditional
chemotherapeutic
drugs
lack
optimal
efficacy
and
invoke
severe
adverse
effects
in
cancer
patients.
Polydatin
(PD),
a
phytomedicine,
has
gradually
gained
attention
due
to
its
antitumor
activity.
However,
low
solubility
poor
bioavailability
are
still
cornerstone
issues.
The
present
study
aimed
fabricate
develop
hyaluronic
acid/lactoferrin-double
coated
PD/PLGA
nanoparticles
Lung
adenocarcinoma,
recognized
as
one
of
the
most
formidable
malignancies
with
a
dismal
prognosis
and
low
survival
rates,
poses
significant
challenge
in
its
treatment.
This
article
delineates
design
development
carbon
dot-vesicle
conjugate
(HACD-TMAV)
for
efficient
cytotoxicity
towards
lung
cancer
cells
by
target
selective
delivery
glutamine
inhibitor
6-diazo-5-oxo-L-norleucine
(DON)
within
CD44-enriched
A549
cells.
HACD-TMAV
is
composed
hyaluronic
acid-based
dots
(HACDs)
trimesic
vesicles
(TMAV),
which
are
bound
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Introduction
Non-small
cell
lung
cancer
(NSCLC)
continues
to
pose
a
considerable
health
challenge
with
few
therapeutic
alternatives.
Liquid
crystalline
nanoparticles
(LCN)
are
nanostructured
drug
delivery
systems
made
of
lipid-based
amphiphilic
materials
that
self-assemble
into
phases
in
aqueous
environments.
LCN
have
become
promising
way
treat
NSCLC
owing
their
specific
properties
make
them
useful
for
targeted
and
controlled
release.
