Antioxidants, Год журнала: 2024, Номер 13(11), С. 1286 - 1286
Опубликована: Окт. 24, 2024
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most recent definition for associated with metabolic syndrome. The results of and observational studies suggest a potential beneficial effect food-derived flavonoids in some chronic diseases, including MASLD. study aims to evaluate protective role diet subjects without MASLD belonging cohort living South Italy.
Язык: Английский
Nutrients, Год журнала: 2025, Номер 17(6), С. 956 - 956
Опубликована: Март 9, 2025
Non-alcoholic fatty liver disease (NAFLD) is considered a significant global health issue related to serious metabolic disorders. However, effective pharmacological treatments are still limited. Flavonoids, wide group of polyphenol substances, exert anti-inflammatory and lipid-lowering effects in preclinical data. Thus, implementing these research findings clinical practice could significantly help manage NAFLD its consequences. This narrative review assesses the therapeutic potential flavonoids managing NAFLD. The collected randomized controlled trials (RCTs) meta-analyses RCTs from past five years concerning impact on A total 20 studies were selected according predetermined inclusion criteria, comprising thirteen seven meta-analyses. underscores beneficial management through enhancement lipid metabolism, reduction hepatic steatosis, provision actions. Clinical demonstrate that interventions rich flavonoids, including quercetin, epigallocatechin gallate, naringenin, isoflavones, substantially reduce fat content enhance enzyme profiles, with certain compounds exhibiting superior efficacy particular subgroups, such as older adults females. Nonetheless, whereas therapies diminish their effect fibrosis constrained. To sum up, exhibit supplementary for by enhancing function, inflammation. Additional extensive necessary create uniform treatment methods ascertain long-term advantages.
Язык: Английский
Процитировано
3
Phytomedicine, Год журнала: 2023, Номер 121, С. 155100 - 155100
Опубликована: Сен. 18, 2023
Язык: Английский
Процитировано
26
Antioxidants, Год журнала: 2023, Номер 12(11), С. 1928 - 1928
Опубликована: Окт. 29, 2023
Chronic liver disease (CLD) affects a significant portion of the global population, leading to substantial number deaths each year. Distinct forms like non-alcoholic fatty (NAFLD) and alcoholic (ALD), though they have different etiologies, highlight shared pathologies rooted in oxidative stress. Central metabolism, mitochondria are essential for ATP production, gluconeogenesis, acid oxidation, heme synthesis. However, diseases NAFLD, ALD, fibrosis, mitochondrial function is compromised by inflammatory cytokines, hepatotoxins, metabolic irregularities. This dysfunction, especially electron leakage, exacerbates production reactive oxygen species (ROS), augmenting damage. Amidst this, nuclear factor erythroid 2-related 2 (NRF2) emerges as cellular protector. It not only counters stress regulating antioxidant genes but also maintains health overseeing autophagy biogenesis. The synergy between NRF2 modulation introduces new therapeutic potentials CLD, focusing on preserving integrity against threats. review delves into intricate role shedding light innovative strategies its prevention treatment, through pathways.
Язык: Английский
Процитировано
24
Nature Aging, Год журнала: 2024, Номер 4(9), С. 1290 - 1307
Опубликована: Июнь 28, 2024
Язык: Английский
Процитировано
17
Nutrition and Diabetes, Год журнала: 2024, Номер 14(1)
Опубликована: Май 22, 2024
Abstract Aim To examine the associations of a diet high in flavonoid-rich foods, as reflected by “Flavodiet Score” (FDS), major individual food contributors to flavonoid intake, and subclasses with type 2 diabetes (T2D) risk UK Biobank cohort. Materials methods Flavonoid intakes were estimated from ≥2 dietary assessments among 113,097 study participants [age at enrolment: 56 ± 8 years; 57% female] using U.S Department Agriculture (USDA) databases. Multivariable Cox proportional hazards models used investigate between exposures T2D. Results During 12 years follow-up, 2628 incident cases T2D identified. A higher FDS (compared lower [Q4 vs. Q1]), characterised an average 6 servings foods per day, was associated 26% [HR: 0.74 (95% CI: 0.66–0.84), p trend = <0.001]. Mediation analyses showed that body fatness basal inflammation, well better kidney liver function partially explain this association. In food-based analyses, black or green tea, berries, apples significantly 21%, 15%, 12% risk. Among subclasses, 19–28% risks observed those highest, compared lowest intakes. Conclusions consumption risk, potentially mediated benefits obesity/sugar metabolism, function. Achievable increases specific have potential reduce
Язык: Английский
Процитировано
11
Frontiers in Microbiology, Год журнала: 2024, Номер 15
Опубликована: Апрель 4, 2024
Non-alcoholic fatty liver disease (NAFLD) is increasingly recognized for its global prevalence and potential progression to more severe diseases such as non-alcoholic steatohepatitis (NASH). The gut microbiota plays a pivotal role in the pathogenesis of NAFLD, yet detailed characteristics ecological alterations microbial communities during from (NAFL) NASH remain poorly understood. Methods: In this study, we conducted comparative analysis composition individuals with NAFL elucidate differences characteristics. We utilized 16S rRNA sequencing compare intestinal among healthy control group (65 cases), (64 (53 cases). Random forest machine learning database validation methods were employed analyze data. Results: Our findings indicate significant decrease diversity flora NAFLD ( p < 0.05). At phylum level, high abundances Bacteroidetes Fusobacteria observed both patients, whereas Firmicutes less abundant. genus Prevotella expression was seen (AUC 0.738), an increase combination Megamonas Fusobacterium noted 0.769). Furthermore, KEGG pathway highlighted disturbances various types glucose metabolism pathways compared group, well notably compromised flavonoid flavonol biosynthesis functions. study uncovers distinct microecological changes within transition NASH, providing insights that could facilitate discovery novel biomarkers therapeutic targets NAFLD.
Язык: Английский
Процитировано
8
Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3122 - 3145
Опубликована: Апрель 12, 2024
Abstract Liver fibrosis is a dynamic pathological process that can be triggered by any chronic liver injury. If left unaddressed, it will inevitably progress to the severe outcomes of cirrhosis or even hepatocellular carcinoma. In past few years, prevalence and fatality hepatic have been steadily rising on global scale. As result its intricate pathogenesis, quest for pharmacological interventions targeting has remained formidable challenge. Currently, no pharmaceuticals are exhibiting substantial clinical efficacy in management fibrosis. Hence, utmost importance expedite development novel therapeutics treatment this condition. Various research studies revealed ability different natural flavonoid compounds alleviate reverse through range mechanisms, which related regulation inflammation, oxidative stress, synthesis secretion fibrosis‐related factors, stellate cells activation, proliferation, extracellular matrix degradation these compounds. This review summarizes sources flavonoids with inhibitory effects over last decades. The anti‐fibrotic increasingly studied, making them potential source drugs due their good biosafety.
Язык: Английский
Процитировано
8
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Июнь 21, 2024
This systematic review and meta-analysis of clinical observational studies aims to clarify the correlation between intake levels fruits vegetables non-alcoholic fatty liver disease (NAFLD).
Язык: Английский
Процитировано
8
Nutrients, Год журнала: 2025, Номер 17(3), С. 564 - 564
Опубликована: Янв. 31, 2025
Background: Insufficient treatment options are available for metabolic dysfunction-associated steatotic liver disease (MASLD). Flavonoids and topiramate have been studied weight loss but need investigation into their effects on metabolism. This study’s aim was to examine the of flavonoids or glucose carbon flux in a cell culture model steatosis. Methods: Steatosis induced HepG2 cells through exposure oleic acid (OA, 0.5 mml/L) conjugated bovine serum albumin (2:1). Additionally, 50% U13C-glucose supplied medium as stable isotope tracer. Cells were treated with DMSO, 10 μM naringenin, morin, silibinin, (44 μM) 72 h. A non-steatotic, untreated control included. Cell extracts analyzed by gas chromatography/mass spectrometry mass isotopomer distribution analysis glycogen synthesis, de novo fatty tricarboxylic (TCA) cycle activity, ribose synthesis. Groups compared ANOVA Tukey’s pair-wise testing. Results: Compared controls, OA-exposed exhibited increased lipid accumulation ORO staining (1.6-fold), enhanced palmitate reduced pyruvate carboxylase/pyruvate dehydrogenase (PC/PDH) ratio, Treatment silibinin ameliorated (1.3-fold) mitigated enhancement Morin-treated synthesis suppressed Conclusions: Potential mechanisms may include suppression relative decrease PDH pathway. Further studies needed potential utility MASLD based specific effects.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown
Опубликована: Июнь 12, 2023
Abstract Understanding the genetic basis of biological aging in multi-organ systems is vital for elucidating age-related disease mechanisms and identifying therapeutic interventions. This study characterized architecture age gap (BAG) across nine human organ 377,028 individuals European ancestry from UK Biobank. We discovered 393 genomic loci-BAG pairs (P-value<5×10 -8 ) linked to brain, eye, cardiovascular, hepatic, immune, metabolic, musculoskeletal, pulmonary, renal systems. observed BAG-organ specificity inter-organ connections. Genetic variants associated with BAGs are predominantly specific respective system while exerting pleiotropic effects on traits multiple A gene-drug-disease network confirmed involvement metabolic BAG-associated genes drugs targeting various disorders. correlation analyses supported Cheverud’s Conjecture 1 – between mirrors their phenotypic correlation. causal revealed potential linking chronic diseases (e.g., Alzheimer’s disease), body weight, sleep duration BAG Our findings shed light promising interventions enhance health within a complex network, including lifestyle modifications drug repositioning strategies treating diseases. All results publicly available at https://labs-laboratory.com/medicine .
Язык: Английский
Процитировано
13