Exploring Alzheimer's Disease Treatment: Established Therapies and Novel Strategies for Future Care

European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177520 - 177520

Опубликована: Март 1, 2025

Язык: Английский

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Agarwood as a neuroprotective agent: a comprehensive review of existing evidence and potential avenues for future research

Phytochemistry Reviews, Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

Язык: Английский

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Alleviation of Neurological Disorders by Targeting Neurodegenerative-Associated Enzymes: Natural and Synthetic Molecules

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(10), С. 4707 - 4707

Опубликована: Май 14, 2025

Neurological disorders, encompassing neurodegenerative and neuroinflammatory conditions, present significant public health clinical challenges. Recent research has elucidated the pivotal role of various enzymes in onset progression these disorders. This review explores therapeutic potential targeting with natural synthetic molecules. Key enzymes, including acetylcholinesterase, monoamine oxidase, beta-secretase, tau kinases, caspases, cyclooxygenase-2, are implicated diseases such as Alzheimer's disease, Parkinson's multiple sclerosis. Modulating can alleviate symptoms, slow disease progression, or reverse pathological changes. Natural molecules derived from plants, microbes, seaweeds, animals have long been noted for their potential. Their ability to interact specific high specificity minimal side effects makes them promising candidates treatment. These agents provide a foundation developing targeted therapies improved safety profiles. Simultaneously, development chemistry resulted designed inhibit precision. examines progress creating small molecules, peptides, enzyme inhibitors through sophisticated drug design techniques. It evaluates efficacy, safety, mechanisms agents, highlighting application. The offers comprehensive overview recent advancements enzyme-targeted neurological covering both investigated preclinical settings. discusses which exert effects, challenges faced development, future directions. By synthesizing current knowledge, this paper aims illuminate interventions managing showcasing promise limitations approaches.

Язык: Английский

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Psychoactive Plant Database: a phytochemical resource for neurological drug discovery

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 23, 2025

Язык: Английский

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Polyherbal formulation mitigates age-associated cognitive deficits in rats

Journal of Ayurveda and Integrative Medicine, Год журнала: 2025, Номер 16(3), С. 101131 - 101131

Опубликована: Май 1, 2025

Age-related cognitive decline is a common biological phenomenon that appears to be driven by accelerated oxidative stress pathways. As natural polyherbal phytoconstituents positively modulate such pathological changes, herbal formulations are gaining notable attention in the mitigation of age-associated impairments. To study effect extracts on functions 52-54 weeks old rats compared young adult rats. The anxiety as well learning and memory were assessed employing elevated plus maze, Morris water maze (MWM), novel object recognition test (NORT). levels antioxidant enzymes, acetylcholinesterase (AChE), neurotransmitters, cytokines, brain-derived neurotrophic factor (BDNF) estimated blood and/or brain samples using biochemical assays, LC-MS/MS, ELISA, immunofluorescence methods. peroral administration plant for 12 showed trends toward improvement MWM NORT locomotor activity anxiety-like behavior remained similar vs. aged We noted lowered enzymes (superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase, homocysteine) AChE frontal cortex also observed negative impact aging neurotransmitters (dopamine, noradrenaline, 5-HT), cytokines (TNF-α, IL-6, CRP), BDNF, NeuN expression hippocampus/frontal altered these AChE, other biogenic substances reversed polyherbal-recipient Our results indicate memory-improving formulation may attributed antioxidant, anti-inflammatory, neuroprotective properties. Thus, we suggest utility this Indian delaying onset or reducing

Язык: Английский

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Benincasa hispida Alleviates Stress and Anxiety in a Zebrafish (Danio rerio) Model

Life, Год журнала: 2024, Номер 14(3), С. 379 - 379

Опубликована: Март 13, 2024

The Ayurvedic medical system uses fruits of the Benincasa hispida plant to treat mental diseases, including schizophrenia. goal current study was assess aqueous extract B. fruit’s ability relieve stress and anxiety induced in zebrafish models using neuropharmacological evaluation, which included determining behavioral parameters tests such as T-maze, open tank test (OTT), light–dark preference (LDPT). After measuring survival rate for 96 h, LC50 found be 5 µg. AChE (acetylcholinesterase) inhibitory activity status antioxidant enzymes (SOD, CAT, LDH) were also used evaluate toxicity. Furthermore, administration fruit increased frequency entry duration time spent bright section, suggesting a noteworthy reduction levels anxiety. Additionally, antistress antianxiety confirmed by docking studies’ mechanism action, involves receptor binding stability homogalactaconan molecule fruit. Overall, findings this demonstrated that is viable therapeutic creation novel drugs treatment since it has advantage reversing negative effects

Язык: Английский

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Dopamine and central dopaminergic circuitry in neurodegenerative diseases: Roles and mechanisms of action of natural phytochemicals

Pharmacological Research - Natural Products, Год журнала: 2024, Номер 3, С. 100050 - 100050

Опубликована: Май 5, 2024

Язык: Английский

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Demaghi, a polyherbal formulation, mitigates aluminum chloride-induced neurological impairment in mice: Insights from phytochemical analysis and behavioral assessment

Heliyon, Год журнала: 2023, Номер 9(11), С. e21234 - e21234

Опубликована: Окт. 27, 2023

Herbal products have been very popular in Pakistan for their curative significance against various disorders. Demaghi (DEMG) is a widely used herbal product claimed to own natural substances having neuroprotective potential. The current study aims scientifically validate the chemical composition as well its claims of this tonic. commercially available was chemically characterized phytocomposition. mice were treated with two doses (DEMG 50 mg and 100 mg/kg/day), effects prolonged exposure on animal anxiety, memory, depression noted through series behavioral tests AlCl3-induced memory deficient model. Besides that, dissected brains biochemically analyzed oxidative stress markers acetylcholinesterase activity, histopathological changes. outcomes showed that DEMG (100 mg/kg/day) has prominent anti-anxiety effects, memory-enhancing properties, anti-depressants observed memory-deficient Biochemical assays also greater decrease tested animals mg/kg/day DEMG. analysis revealed administration reduced toxicity. UPLC-MS results presence many phytoconstituents, which support cholinergic signaling in-silico studies. research validates neurological benefits memory-boosting properties. phytocompounds present exert possibly by enhancing neurotransmission combating neurotoxin-induced stress.

Язык: Английский

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Navigating the Digital Neurolandscape: Analyzing the Social Perception of and Sentiments Regarding Neurological Disorders through Topic Modeling and Unsupervised Research Using Twitter

Information, Год журнала: 2024, Номер 15(3), С. 152 - 152

Опубликована: Март 8, 2024

Neurological disorders represent the primary cause of disability and secondary mortality globally. The incidence prevalence most notable neurological are growing rapidly. Considering their social public perception by using different platforms like Twitter can have a huge impact on patients, relatives, caregivers professionals involved in multidisciplinary management disorders. In this study, we collected analyzed all tweets posted English or Spanish, between 2007 2023, referring to headache disorders, dementia, epilepsy, multiple sclerosis, spinal cord injury Parkinson’s disease search engine that has access 100% publicly available tweets. aim our work was deepen understanding addressing three major objectives: (1) analyzing number temporal evolution both Spanish discussing (dementias, disease, injury, epilepsy disorders); (2) determining main thematic content posts interest they generated temporally topic modeling; (3) sentiments associated with topics were previously collected. Our results show dementias were, far, common whose treatment discussed Twitter, included diseases patients claims increase awareness, support research, activities ameliorate development existent/potential treatments approaches significant showing negative emotions fear, anger sadness, some also demonstrating positive joy. Thus, study shows not only is an important active platform implicated dissemination normalization but these entities quite inequitable, greater intervention more accurate information figures media could help convey better current state, project future for general public.

Язык: Английский

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Stem cell transplantation therapy for advanced liver damage -associated neurodegenerative disorders

International Journal of Surgery, Год журнала: 2024, Номер 110(11), С. 6873 - 6882

Опубликована: Июль 23, 2024

Hepatic encephalopathy and other neurodegenerative disorders have profound implications for extensive liver impairment, calling new ways of treating the condition. The application stem cell transplantation to treat these severe is a encouraging technique. This review article digs deep into subject therapy, associated with advanced damage, transplantation. It comprehensively analyses background, rationale, scope, objectives using cells such challenging conditions. topic discussion includes subtleties disorders, function transplantation, possible advantages disadvantages it. relevance patient selection, intraoperative concerns post-transplant care discussed. Further, explores how cell-based therapies can benefit from nanotechnology, specifically it improve distribution, survival, integration better therapeutic results. aims offer thorough analysis regenerative medicine's present future possibilities in dealing intricate relationship between neurodegeneration damage. does this by examining efficacy, safety, long-term impacts will incorporate insights ongoing clinical trials, patent landscape, directions. goal pave way innovative personalized treatment approaches evolving research practice field. Therefore, efforts represent promising frontier medical that alleviate burden HE neurological complications combined cirrhosis.

Язык: Английский

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