Heliyon,
Journal Year:
2023,
Volume and Issue:
9(11), P. e21234 - e21234
Published: Oct. 27, 2023
Herbal
products
have
been
very
popular
in
Pakistan
for
their
curative
significance
against
various
disorders.
Demaghi
(DEMG)
is
a
widely
used
herbal
product
claimed
to
own
natural
substances
having
neuroprotective
potential.
The
current
study
aims
scientifically
validate
the
chemical
composition
as
well
its
claims
of
this
tonic.
commercially
available
was
chemically
characterized
phytocomposition.
mice
were
treated
with
two
doses
(DEMG
50
mg
and
100
mg/kg/day),
effects
prolonged
exposure
on
animal
anxiety,
memory,
depression
noted
through
series
behavioral
tests
AlCl3-induced
memory
deficient
model.
Besides
that,
dissected
brains
biochemically
analyzed
oxidative
stress
markers
acetylcholinesterase
activity,
histopathological
changes.
outcomes
showed
that
DEMG
(100
mg/kg/day)
has
prominent
anti-anxiety
effects,
memory-enhancing
properties,
anti-depressants
observed
memory-deficient
Biochemical
assays
also
greater
decrease
tested
animals
mg/kg/day
DEMG.
analysis
revealed
administration
reduced
toxicity.
UPLC-MS
results
presence
many
phytoconstituents,
which
support
cholinergic
signaling
in-silico
studies.
research
validates
neurological
benefits
memory-boosting
properties.
phytocompounds
present
exert
possibly
by
enhancing
neurotransmission
combating
neurotoxin-induced
stress.
Information,
Journal Year:
2024,
Volume and Issue:
15(3), P. 152 - 152
Published: March 8, 2024
Neurological
disorders
represent
the
primary
cause
of
disability
and
secondary
mortality
globally.
The
incidence
prevalence
most
notable
neurological
are
growing
rapidly.
Considering
their
social
public
perception
by
using
different
platforms
like
Twitter
can
have
a
huge
impact
on
patients,
relatives,
caregivers
professionals
involved
in
multidisciplinary
management
disorders.
In
this
study,
we
collected
analyzed
all
tweets
posted
English
or
Spanish,
between
2007
2023,
referring
to
headache
disorders,
dementia,
epilepsy,
multiple
sclerosis,
spinal
cord
injury
Parkinson’s
disease
search
engine
that
has
access
100%
publicly
available
tweets.
aim
our
work
was
deepen
understanding
addressing
three
major
objectives:
(1)
analyzing
number
temporal
evolution
both
Spanish
discussing
(dementias,
disease,
injury,
epilepsy
disorders);
(2)
determining
main
thematic
content
posts
interest
they
generated
temporally
topic
modeling;
(3)
sentiments
associated
with
topics
were
previously
collected.
Our
results
show
dementias
were,
far,
common
whose
treatment
discussed
Twitter,
included
diseases
patients
claims
increase
awareness,
support
research,
activities
ameliorate
development
existent/potential
treatments
approaches
significant
showing
negative
emotions
fear,
anger
sadness,
some
also
demonstrating
positive
joy.
Thus,
study
shows
not
only
is
an
important
active
platform
implicated
dissemination
normalization
but
these
entities
quite
inequitable,
greater
intervention
more
accurate
information
figures
media
could
help
convey
better
current
state,
project
future
for
general
public.
Life,
Journal Year:
2024,
Volume and Issue:
14(3), P. 379 - 379
Published: March 13, 2024
The
Ayurvedic
medical
system
uses
fruits
of
the
Benincasa
hispida
plant
to
treat
mental
diseases,
including
schizophrenia.
goal
current
study
was
assess
aqueous
extract
B.
fruit’s
ability
relieve
stress
and
anxiety
induced
in
zebrafish
models
using
neuropharmacological
evaluation,
which
included
determining
behavioral
parameters
tests
such
as
T-maze,
open
tank
test
(OTT),
light–dark
preference
(LDPT).
After
measuring
survival
rate
for
96
h,
LC50
found
be
5
µg.
AChE
(acetylcholinesterase)
inhibitory
activity
status
antioxidant
enzymes
(SOD,
CAT,
LDH)
were
also
used
evaluate
toxicity.
Furthermore,
administration
fruit
increased
frequency
entry
duration
time
spent
bright
section,
suggesting
a
noteworthy
reduction
levels
anxiety.
Additionally,
antistress
antianxiety
confirmed
by
docking
studies’
mechanism
action,
involves
receptor
binding
stability
homogalactaconan
molecule
fruit.
Overall,
findings
this
demonstrated
that
is
viable
therapeutic
creation
novel
drugs
treatment
since
it
has
advantage
reversing
negative
effects
International Journal of Surgery,
Journal Year:
2024,
Volume and Issue:
110(11), P. 6873 - 6882
Published: July 23, 2024
Hepatic
encephalopathy
and
other
neurodegenerative
disorders
have
profound
implications
for
extensive
liver
impairment,
calling
new
ways
of
treating
the
condition.
The
application
stem
cell
transplantation
to
treat
these
severe
is
a
encouraging
technique.
This
review
article
digs
deep
into
subject
therapy,
associated
with
advanced
damage,
transplantation.
It
comprehensively
analyses
background,
rationale,
scope,
objectives
using
cells
such
challenging
conditions.
topic
discussion
includes
subtleties
disorders,
function
transplantation,
possible
advantages
disadvantages
it.
relevance
patient
selection,
intraoperative
concerns
post-transplant
care
discussed.
Further,
explores
how
cell-based
therapies
can
benefit
from
nanotechnology,
specifically
it
improve
distribution,
survival,
integration
better
therapeutic
results.
aims
offer
thorough
analysis
regenerative
medicine's
present
future
possibilities
in
dealing
intricate
relationship
between
neurodegeneration
damage.
does
this
by
examining
efficacy,
safety,
long-term
impacts
will
incorporate
insights
ongoing
clinical
trials,
patent
landscape,
directions.
goal
pave
way
innovative
personalized
treatment
approaches
evolving
research
practice
field.
Therefore,
efforts
represent
promising
frontier
medical
that
alleviate
burden
HE
neurological
complications
combined
cirrhosis.
Journal of Biochemical and Molecular Toxicology,
Journal Year:
2024,
Volume and Issue:
38(11)
Published: Oct. 18, 2024
Traumatic
brain
injury
(TBI)
causes
deficits
in
neurological
function,
induces
pathological
changes,
and
increases
oxidative
stress.
The
current
investigation
aimed
to
determine
Daidzein's
neuroprotective
potential
experimental
TBI.
Initially,
the
HT-22
cell
line
exposed
H
Advances in Human Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 15, 2024
Abstract
Neuropharmacology
explores
how
drugs
influence
the
nervous
system
and
their
potential
in
treating
neurological
psychiatric
disorders.
This
review
provides
a
comprehensive
overview
of
mechanisms
through
which
various
impact
neural
processes
therapeutic
applications.
It
covers
major
drug
classes,
including
antipsychotics,
antidepressants,
anxiolytics
neuroprotective
agents,
highlighting
modes
action,
efficacy
limitations.
Advances
development,
such
as
targeted
therapies
novel
compounds,
are
discussed
about
to
improve
treatment
outcomes
for
disorders
schizophrenia,
depression,
anxiety
neurodegenerative
diseases.
Understanding
these
is
crucial
developing
more
effective
safer
treatments.
