Progress in Understanding Oxidative Stress, Aging, and Aging-Related Diseases

Antioxidants, Год журнала: 2024, Номер 13(4), С. 394 - 394

Опубликована: Март 25, 2024

Under normal physiological conditions, reactive oxygen species (ROS) are produced through redox reactions as byproducts of respiratory and metabolic activities. However, due to various endogenous exogenous factors, the body may produce excessive ROS, which leads oxidative stress (OS). Numerous studies have shown that OS causes a variety pathological changes in cells, including mitochondrial dysfunction, DNA damage, telomere shortening, lipid peroxidation, protein modification, all can trigger apoptosis senescence. also induces aging-related diseases, such retinal disease, neurodegenerative osteoarthritis, cardiovascular cancer, ovarian prostate disease. In this review, we aim introduce multiple internal external triggers mediate ROS levels rodents humans well relationship between OS, aging, diseases. Finally, present statistical analysis effective antioxidant measures currently being developed applied field aging research.

Язык: Английский

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The Potential of Superoxide Dismutase-Rich Tetraselmis chuii as a Promoter of Cellular Health

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1693 - 1693

Опубликована: Фев. 16, 2025

Tetraselmis chuii (T. chuii) is a green, marine, eukaryotic, microalgae that was authorized in the European Union (EU) as novel food for human consumption 2014, and supplement 2017. This narrative review will provide an overview of preclinical clinical trials assessing efficacy T. chuii-derived ingredient, characterized by high superoxide dismutase (SOD) activity (SOD-rich chuii), to improve various aspects cellular health. Collectively, results from vitro, more importantly vivo research, support SOD-rich potential promoter Principally, ingredient appears function indirect antioxidant boosting intracellular systems. Moreover, it can positively modulate inflammatory status up-regulating anti-inflammatory down-regulating pro-inflammatory cytokines factors. In addition, promote health though protecting DNA damage, immune function, strengthening cell structure integrity, modulating signaling pathways. There also some evidence suggest may mitochondrial through up-regulation genes linked biogenesis ATP synthesis. From conducted date, transcriptional activation nuclear factor erythroid 2-related 2 (NRF2) sirtuin 1 (SIRT1) appear be important mediating effects on These exciting preliminary observations represent natural blue with enhance

Язык: Английский

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Cocoa flavanols, Nrf2 activation, and oxidative stress in peripheral artery disease: mechanistic findings in muscle based on outcomes from a randomized trial

AJP Cell Physiology, Год журнала: 2024, Номер 326(2), С. C589 - C605

Опубликована: Янв. 8, 2024

The current study supports the hypothesis that in people with PAD, cocoa flavanols activate Nrf2, thereby increasing antioxidant protein levels, protecting against skeletal muscle damage, and mitochondrial abundance. These results suggest Nrf2 activation may be an important therapeutic target for improving walking performance PAD.

Язык: Английский

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Protective effect of cafestol against doxorubicin-induced cardiotoxicity in rats by activating the Nrf2 pathway

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Июнь 12, 2023

Doxorubicin (DOX) is an efficient antineoplastic agent with a broad antitumor spectrum; however, doxorubicin-associated cardiotoxic adverse effect through oxidative damage and apoptosis limits its clinical application. Cafestol (Caf) naturally occurring diterpene in unfiltered coffee unique antioxidant, antimutagenic, anti-inflammatory activities by activating the Nrf2 pathway. The present study aimed to investigate potential chemoprotective of cafestol on DOX-induced cardiotoxicity rats. Wistar albino rats both sexes were administered (5 mg/kg/day) for 14 consecutive days oral gavage alone or doxorubicin which was injected as single dose (15 mg/kg intraperitoneally at day 14) induce toxicity. result showed that Caf significantly improved cardiac injury induced doxorubicin, decreased serum levels CK-MB, LDH, ALP, ALT, histopathological changes. In addition, inhibited stress seen reduced level MDA increased GSH, SOD, CAT, Gpx-1 tissue levels; enhanced gene protein expression promoted downstream antioxidant genes HO-1 NQO-1 downregulated Keap1 NF-κB genes' expression; inflammatory mediators, TNF-α, IL-1β modulating Bax Casp 3 TUNEL-positive cardiomyocytes. conclusion, confirmed effects regulation response pathway; this suggests may serve adjuvant chemotherapy alleviate toxicities.

Язык: Английский

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Berberine modulates cardiovascular diseases as a multitarget-mediated alkaloid with insights into its downstream signals using in silico prospective screening approaches

Saudi Journal of Biological Sciences, Год журнала: 2024, Номер 31(5), С. 103977 - 103977

Опубликована: Март 11, 2024

Atherosclerosis is potentially correlated with several cardiac disorders that are greatly associated cellular oxidative stress generation, inflammation, endothelial cells dysfunction, and many cardiovascular complications. Berberine a natural isoquinoline alkaloid compound widely modulates pathogenesis of atherosclerosis through its different curative potentials. This in silico screening study was designed to confirm the potent restorative properties berberine chloride as multitarget-mediated against CVDs their complications screening, identifying, visualizing, evaluating binding models, affinities, interactions toward CVDs-related targets direct and/or indirect-mediated signals via inhibiting ER apoptotic activating autophagy pathway. The drug-likeness were predicted using computational QSAR/ADMET Lipinski's RO5 analyses well molecular docking simulations. berberine-binding modes, residues-interaction patterns, free energies scores towards estimated tools. Furthermore, pharmacokinetic toxicological features clearly determined. According this virtual study, could restore function improve pathogenic atherosclerotic alleviating signals, autophagy, improving insulin sensitivity, decreasing hyperglycemia dyslipidemia, increasing intracellular RCT signaling, attenuating vascular upregulating antioxidant defenses tissues. In modulated targets, including SIGMAR1, GRP78, CASP3, BECN1, PIK3C3, SQSTM1/p62, LC3B, GLUT3, INSR, LDLR, LXRα, PPARγ, IL1β, IFNγ, iNOS, COX-2, MCP-1, IL10, GPx1, SOD3.

Язык: Английский

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Dietary Supplements as Modulators of the Nrf2 Pathway to Enhance Intracellular Antioxidant Responses and Protect Against Dyslipidemia-Associated Cardiovascular Complications

Food Reviews International, Год журнала: 2025, Номер unknown, С. 1 - 29

Опубликована: Янв. 23, 2025

The market for dietary supplements has significantly grown due to their envisaged health benefits. These bioactive compounds are actively explored therapeutic benefits against vast metabolic complications abundant antioxidant properties. Nuclear factor erythroid 2-related 2 (Nrf2) modulation as a cytoprotective mechanism oxidative stress-induced stress garnered interest, particularly through its regulation by many supplements. This review aims evaluate and critically discuss the available evidence on potential effects of supplements, including prominently used nutraceuticals dyslipidemia-associated cardiovascular complications. Notably, this highlights these modulate Nrf2 pathway, enhancing intracellular antioxidants providing protection Beyond value preclinical ability regulate pathway counteract damage, also incorporates clinical supporting in dyslipidemia-related conditions. Fundamental pharmacological aspects such bioavailability relevant biological properties discussed inform further development diseases.

Язык: Английский

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Shikimic acid protects against doxorubicin-induced cardiotoxicity in rats

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Март 8, 2025

Abstract Doxorubicin (DOX) is used to treat a variety of malignancies; however, its cardiotoxicity limits effectiveness. Shikimic acid (SA) showed several promising biomedical applications. This study investigated the protective effect SA on DOX-induced in male rats. The ADMETlab 2.0 web server was predict pharmacokinetic properties SA. Molecular docking studies were conducted using AutoDock Vina. Fifty rats divided into 4 groups ( n = 10); G1 negative control; G2 injected with mg/kg DOX intraperitoneally (i.p.) once week for month; G3 gavaged by 1/10 LD 50 (280 mg/kg) daily month, and G4 as G3. After hematological, biochemical, molecular, histopathological investigations assessed. results that treatment led significant amelioration restoring inflammatory biomarkers, antioxidant gene expression, cardiac alterations. Importantly, impact against DOX-promoted deterioration targeting Nrf-2/Keap-1/HO-1/NQO-1 signaling pathway, which turn induces agents. These findings suggest could potentially mitigate toxicity during DOX-based chemotherapy.

Язык: Английский

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Targeting the redox system for cardiovascular regeneration in aging

Aging Cell, Год журнала: 2023, Номер 22(12)

Опубликована: Ноя. 13, 2023

Abstract Cardiovascular aging presents a formidable challenge, as the process can lead to reduced cardiac function and heightened susceptibility cardiovascular diseases. Consequently, there is an escalating, unmet medical need for innovative effective regeneration strategies aimed at restoring rejuvenating tissues. Altered redox homeostasis accumulation of oxidative damage play pivotal role in detrimental changes stem cell cellular senescence, hampering regenerative capacity aged system. A mounting body evidence underscores significance targeting machinery restore self‐renewal enhance their differentiation potential into youthful lineages. Hence, holds promise target optimizing therapies. In this context, we delve current understanding regulating reprogramming processes that impact Furthermore, offer insights recent translational clinical implications redox‐targeting compounds enhancing therapies

Язык: Английский

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Targeting the PANoptosis signaling pathway for myocardial protection: therapeutic potential of Xian Ling Gu Bao capsule

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Introduction: Myocardial infarction (MI), the most prevalent ischemic heart disease, constitutes a primary cause of global cardiovascular disease with incidence and mortality. The pathogenesis MI is exceedingly intricate, PANoptosis playing pivotal role in its pathological process. Xian Ling Gu Bao capsule (XLGB) contains various active components, including flavonoids, terpenes, phenylpropanoids, exhibits wide range pharmacological activities. However, it remains unclear whether XLGB can protect myocardium from damage after MI. This study aimed to investigate impact on isoprenaline (ISO)-induced mice potential mechanisms. Methods: assessed protective effects against ISO-induced through techniques such as echocardiography, HE staining, Masson enzyme-linked immunosorbent assay (ELISA). Furthermore, mechanisms XLGB's were explored using bioinformatics, molecular docking, dynamics simulations. These further validated immunofluorescence staining Western blotting. Results: results demonstrated that doses exhibited significant reduction myocardial injury induced by infarction. Intriguingly, higher dosages displayed superior therapeutic efficacy compared positive control metoprolol. effect primarily achieved inhibition oxidative stress inflammatory processes. we have elucidated protected MI-induced suppressing PANoptosis, critical played NLRP3/Caspase3/RIP1 signaling pathway. Of particular note, compounds found directly interact NLRP3/Caspase3/RIP1, discovery docking suggests may be target for XLGB-induced protection. Conclusion: In summary, our findings reveal novel property XLGB: reverses following inhibiting NLRP3/Caspase3/RIP1-mediated

Язык: Английский

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Efficacy of Thymoquinone and Hesperidin in Attenuating Cardiotoxicity from 5-Fluorouracil: Insights from In Vivo and In Silico Studies

Toxics, Год журнала: 2024, Номер 12(9), С. 688 - 688

Опубликована: Сен. 23, 2024

5-Fluorouracil (5-FU) is widely used in chemotherapy but poses serious risks of cardiotoxicity, which can significantly affect treatment outcomes. Identifying interventions that prevent these adverse effects without undermining anticancer efficacy crucial. This study investigates the Thymoquinone (TQ) and Hesperidin (HESP) preventing cardiotoxicity induced by 5-FU Wistar rats elucidates molecular interactions through docking studies. We employed an experimental design involving multiple groups exposed to 5-FU, with concurrent administration TQ HESP. Cardiac function markers, oxidative stress indicators, inflammatory markers were assessed. Additionally, was analyze interaction HESP key proteins. Treatment not only lowered levels cardiac enzymes also improved antioxidant capacity reduced inflammation tissues. Notably, combination provided more significant protective than either agent alone. Molecular supported findings, showing effective binding targets. demonstrate potential as agents against 5-FU-treated rats, their combined use offering enhanced protection. These findings suggest a viable strategy for reducing associated chemotherapy.

Язык: Английский

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