Journal of Ethnopharmacology, Год журнала: 2022, Номер 303, С. 115879 - 115879
Опубликована: Ноя. 10, 2022
Язык: Английский
Molecules, Год журнала: 2024, Номер 29(10), С. 2198 - 2198
Опубликована: Май 8, 2024
As links between genotype and phenotype, small-molecule metabolites are attractive biomarkers for disease diagnosis, prognosis, classification, drug screening treatment, insight into understanding pathology identifying potential targets. Metabolomics technology is crucial discovering targets of involved in phenotype. Mass spectrometry-based metabolomics has implemented applications various fields including target discovery, explanation mechanisms compound screening. It used to analyze the physiological or pathological states organism by investigating changes endogenous associated metabolism from complex metabolic pathways biological samples. The present review provides a critical update high-throughput functional techniques diverse applications, recommends use mass metabolite signatures that provide valuable insights We also recommend using as powerful tool patterns, efficacy evaluation herbal medicine.
Язык: Английский
Процитировано
16
Analytical Science Advances, Год журнала: 2023, Номер 4(5-6), С. 133 - 153
Опубликована: Апрель 26, 2023
The development of ambient ionization mass spectrometry (AIMS) has transformed analytical science, providing the means performing rapid analysis samples in their native state, both and out laboratory. capacity to eliminate sample preparation pre-MS separation techniques, leading true real-time analysis, led AIMS naturally gaining a broad interest across scientific community. Since introduction first techniques mid-2000s, field exploded with dozens novel ion sources, an array intriguing applications, evident growing diverse areas study. As continues surge forward each year, are increasingly becoming commonplace laboratories around world. This annual review provides overview applications throughout 2022, specific focus on some major fields research, including forensic disease diagnostics, pharmaceuticals food sciences. New methods introduced, demonstrating unwavering drive community further advance this exciting push boundaries what chemistry can achieve.
Язык: Английский
Процитировано
26
MedComm, Год журнала: 2024, Номер 5(9)
Опубликована: Сен. 1, 2024
Abstract Cell death regulation is essential for tissue homeostasis and its dysregulation often underlies cancer development. Understanding the different pathways of cell can provide novel therapeutic strategies battling cancer. This review explores several key mechanisms apoptosis, necroptosis, autophagic death, ferroptosis, pyroptosis. The research gap addressed involves a thorough analysis how these be precisely targeted therapy, considering tumor heterogeneity adaptation. It delves into genetic epigenetic factors signaling cascades like phosphatidylinositol 3‐kinase/protein kinase B/mammalian target rapamycin (PI3K/AKT/mTOR) mitogen‐activated protein kinase/extracellular signal‐regulated (MAPK/ERK) pathways, which are critical death. Additionally, interaction microenvironment with cells, particularly influence hypoxia, nutrient deprivation, immune cellular interactions, explored. Emphasizing strategies, this highlights emerging modulators inducers such as B lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics, tumour necrosis factor‐related apoptosis‐inducing ligand (TRAIL), chloroquine, innovative approaches to induce ferroptosis provides insights therapy's future direction, focusing on multifaceted circumvent drug resistance. examination evolving underlines considerable clinical potential continuous necessity in‐depth exploration within scientific domain.
Язык: Английский
Процитировано
12
Food Chemistry, Год журнала: 2023, Номер 435, С. 137504 - 137504
Опубликована: Окт. 5, 2023
Язык: Английский
Процитировано
17
Food Chemistry, Год журнала: 2023, Номер 436, С. 137737 - 137737
Опубликована: Окт. 11, 2023
Язык: Английский
Процитировано
16
Journal of Ethnopharmacology, Год журнала: 2022, Номер 292, С. 115216 - 115216
Опубликована: Март 22, 2022
Язык: Английский
Процитировано
25
Chinese Medicine, Год журнала: 2023, Номер 18(1)
Опубликована: Сен. 8, 2023
Panax japonicus var. major (PJM) belongs to the well-known ginseng species used in west China for hundreds of years, which has effects lung tonifying and yin nourishing, exerts analgesic, antitussive, hemostatic activities. Compared with other species, chemical composition spatial tissue distribution bioactive ginsenosides PJM have seldom been investigated.Ultra-high performance liquid chromatography/quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS) desorption electrospray ionization-mass imaging (DESI-MSI) were integrated systematic characterization studies rhizome PJM. Considering great difficulty exposing minor saponins, apart from conventional Auto MS/MS (M1), two different precursor ions list-including data-dependent acquisition (PIL-DDA) approaches, involving direct input an in-house library containing 579 known (M2) inclusion target precursors screened MS1 data by defect filtering (M3), developed. The situ various was profiled based on DESI-MSI a range m/z 100-1500 negative ion mode, processed High Definition Imaging (HDI) software.Under optimized condition, 272 identified or tentatively characterized, 138 thereof possibly not ever reported genus. They composed 75 oleanolic acid type, 22 protopanaxadiol 52 protopanaxatriol 16 octillol 19 malonylated, 35 C-17 side-chain varied, 53 others. In addition, experiment unveiled differentiated but main location cork layer phloem rhizome. abundance high slice PJM, consistent results obtained UHPLC/QTOF-MS.Comprehensive achieved, large amount unknown structures primarily. We, first time, subtypes These can benefit quality control further development species.
Язык: Английский
Процитировано
14
Natural Product Research, Год журнала: 2025, Номер unknown, С. 1 - 7
Опубликована: Янв. 31, 2025
Two new phenolic compounds aconitol A (1) and B (2), together with three known including one constituent (3) two diterpenoid alkaloids (4-5), were isolated from the roots of Aconitum pendulum. Their structures assigned by HRESIMS, extensive spectral methods compared literature data. All obtained (1-5) tested for their inhibitory activity against NO production in LPS-activated RAW 264.7 macrophages. Compound 1 5 showed moderate effects.
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Янв. 31, 2025
Spatial metabolomics is an emerging technology that integrates mass spectrometry imaging (MSI) with metabolomics, offering a novel visual perspective for traditional analysis. This enables in-depth analysis in three dimensions: qualitative, quantitative, and localization of metabolites. precisely reflects the characteristics metabolic network changes metabolites within entire tissues or specific micro-regions. It provides detailed understanding pharmacodynamic material basis mechanisms action. These capabilities suggest spatial can offer significant technical support studying complex pathophysiology mental disorders. Although underlying disorders have been reviewed multiple times, this paper comprehensive comparison between metabolomics. also summarizes latest progress challenges applying to study Chinese medicine.
Язык: Английский
Процитировано
0
Phytomedicine, Год журнала: 2022, Номер 108, С. 154534 - 154534
Опубликована: Ноя. 10, 2022
Язык: Английский
Процитировано
22