Advances in medical diagnosis, treatment, and care (AMDTC) book series,
Год журнала:
2024,
Номер
unknown, С. 85 - 114
Опубликована: Дек. 17, 2024
The
discovery
of
biomarkers
has
revolutionized
the
field
oncology,
providing
critical
insights
into
processes
tumour
initiation
and
progression.
Biomarkers,
which
can
be
genetic,
proteomic,
or
metabolic
in
nature,
serve
as
vital
indicators
for
early
cancer
detection,
prognosis,
personalized
treatment
strategies.
Tumour
undergoes
various
stages
characterized
by
alterations
microenvironment,
angiogenesis,
ultimately
metastasis.
Understanding
these
at
molecular
level
is
crucial
identifying
reliable
biomarkers.
Recent
advances
high-throughput
technologies
such
next-generation
sequencing,
mass
spectrometry,
advanced
imaging
techniques
have
significantly
enhanced
ability
to
discover
validate
new
Despite
promising
advancements,
challenges
remain
translation
biomarker
discoveries
clinical
practice.
This
chapter
provides
a
detailed
current
state
discovery,
highlighting
key
findings
future
directions
this
rapidly
evolving
field.
Foods,
Год журнала:
2024,
Номер
13(23), С. 3886 - 3886
Опубликована: Дек. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
World Journal of Gastroenterology,
Год журнала:
2025,
Номер
31(11)
Опубликована: Март 12, 2025
In
this
editorial,
we
critically
evaluate
the
recent
article
by
Niu
et
al
,
which
explores
potential
of
phospholipase
D2
(PLD2)
as
a
biomarker
for
stratifying
disease
severity
in
acute
pancreatitis
(AP).
AP
is
clinically
heterogeneous
inflammatory
condition
that
requires
reliable
biomarkers
early
and
accurate
classification
severity.
PLD2,
an
essential
regulator
neutrophil
migration
responses,
has
emerged
promising
candidate.
Although
current
such
C-reactive
protein
procalcitonin
provide
general
indications
inflammation,
they
lack
specificity
regarding
molecular
mechanisms
underlying
progression.
Recent
studies,
including
research
conducted
suggest
inverse
correlation
between
PLD2
expression
severity,
offering
both
diagnostic
insights
mechanistic
understanding.
This
editorial
evaluates
role
broader
context
research.
Evidence
indicates
decreased
levels
are
associated
with
increased
chemotaxis
cytokine
release,
contributing
to
pancreatic
systemic
inflammation.
However,
several
challenges
remain,
need
large-scale
validation
functional
studies
establish
causation,
standardization
measurement
protocols.
Additionally,
further
investigation
into
temporal
dynamics
its
variability
across
diverse
populations
warranted.
Looking
ahead,
holds
revolutionize
management
integrating
diagnostics
precision
medicine.
The
utilization
multi-omics
approaches
advancements
platforms
could
position
fundamental
diagnosis,
prognosis,
potentially
therapeutic
targeting.
While
promising,
it
crucial
conduct
critical
evaluations
rigorous
validations
PLD2’s
ensure
efficacy
improving
patient
outcomes.
Analytical Methods,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Lung
carcinogenesis
(LC)
is
a
kind
of
disease,
which
threatens
human
health
seriously.
Metabolomic
research
on
bio-fluids
and
tissues
crucial
for
elucidating
the
pathogenesis
LC
understanding
therapeutic
mechanisms
medicines.
In
this
study,
we
established
rat
model
by
induction
with
urethane.
The
anti-tumor
effect
Qi-Yu-San-Long
decoction
(QYSLD)
was
assessed
through
morphology
changes,
histopathological
examination,
inflammation
levels.
Utilizing
metabolomics
technique
based
ultra-performance
liquid
chromatography
coupled
quadrupole
time-of-flight
mass
spectrometry
(UPLC-Q-TOF/MS),
investigated
metabolic
changes
in
plasma
lungs
rats
explored
ameliorative
effects
QYSLD
molecular
Functional
biomarkers
associated
were
identified
relatively
quantified.
results
manifested
that,
contrast
to
control
group,
number
tumor
nodules
levels
group
increased
significantly,
indicating
that
successfully
built.
After
treatment,
lesion
degree
greatly
improved.
A
total
23
differential
metabolites
between
urethane-induced
screened
lung
tissue
studies,
20
considerably
modulated
after
treatment.
Metabolic
pathway
analysis
revealed
primarily
involved
glycerophospholipid
metabolism,
ether
lipid
sphingolipid
arachidonic
acid
metabolism.
Our
findings
provide
potential
intracellular
metabolite
profile
demonstrate
exerts
modulating
multiple
pathways.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 23, 2024
In
recent
years,
tumors
have
emerged
as
a
major
global
health
threat.
An
increasing
number
of
studies
indicate
that
the
production,
development,
metastasis,
and
elimination
tumor
cells
are
closely
related
to
microenvironment
(TME).
Advances
in
artificial
intelligence
(AI)
algorithms,
particularly
large
language
models,
rapidly
propelled
research
medical
field.
This
review
focuses
on
current
state
strategies
applying
AI
algorithms
metabolism
explores
expression
differences
between
normal
cells.
The
analysis
is
conducted
from
perspectives
metabolomics
interactions
within
TME,
further
examining
roles
various
cytokines.
describes
potential
approaches
through
which
can
facilitate
metabolic
studies,
offers
valuable
perspective
for
deeper
understanding
pathological
mechanisms
tumors.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6674 - 6674
Опубликована: Июнь 18, 2024
Acute
coronary
syndrome
(ACS)
is
a
life-threatening
condition
that
requires
prompt
diagnosis
and
therapeutic
intervention.
Although
serum
troponin
I
creatinine
kinase-MB
(CK-MB)
are
established
biomarkers
for
ACS,
reaching
diagnostic
values
ACS
may
take
several
hours.
In
this
study,
we
attempted
to
explore
novel
with
higher
sensitivity
than
of
CK-MB.
The
metabolomic
profiles
18
patients
upon
hospital
arrival
those
the
age-matched
control
(HC)
group
24
healthy
volunteers
were
analyzed
using
liquid
chromatography
time-of-flight
mass
spectrometry.
Volcano
plots
showed
metabolites
whose
concentrations
differed
significantly
between
HC
groups.
Using
these
data,
developed
multiple
logistic
regression
model
diagnosis,
in
which
lysine,
isocitrate,
tryptophan
selected
as
minimum-independent
metabolites.
area
under
receiver
operating
characteristic
curve
value
discriminating
from
was
1.00
(95%
confidence
interval
[CI]:
1.00–1.00).
contrast,
CK-MB
0.917
0.812–1.00)
0.988
CI:
0.966–1.00),
respectively.
This
study
potential
combining
three
plasma
discriminate
