Investigation of geriatric syndromes associated with medication in Japan using insurance claims data
Geriatrics and gerontology international/Geriatrics & gerontology international,
Год журнала:
2023,
Номер
24(1), С. 61 - 67
Опубликована: Дек. 12, 2023
Aim
Multiple
risk
factors
are
involved
in
geriatric
syndrome
(GS)
occurring
older
adults.
Although
drug
therapy
often
contributes
to
GS,
the
specific
causes
among
adults
Japan
remain
unclear.
In
this
study,
we
examined
possible
prescribing
cascade
rate
outpatients
eligible
for
Late‐stage
Elderly
Health
Insurance
and
elucidated
differences
between
GS
associated
with
medication
(GSAM)
trends.
Methods
This
retrospective
study
enrolled
patients
from
health
insurance
claims
data
October
2018
March
2019;
hospitalized
were
excluded.
Two
groups
identified
participants
GS:
(no
use
of
GS‐causing
medications)
possible‐GSAM
(p‐GSAM;
medications).
The
collected
analyzed
using
Bell
Curve
Excel,
statistical
significance
was
set
at
P
<
0.05.
Results
total,
137
781
enrolled.
Of
32
259
who
did
not
medications,
7342
classified
into
group.
Among
105
522
used
8347
as
having
p‐GSAM.
mean
number
prescriptions
significantly
higher
p‐GSAM
group
than
(
0.01).
Furthermore,
all
symptoms
showed
significant
differences,
impaired
appetite
being
most
prevalent
A
suspected
2826
(33.9%)
Conclusion
Impaired
taking
medications
might
lead
cascades.
Further
studies
needed
prevent
such
Geriatr
Gerontol
Int
2024;
24:
61–67
.
Язык: Английский
An investigation of psychoactive polypharmacy and related gender-differences in older adults with dementia: a retrospective cohort study
BMC Geriatrics,
Год журнала:
2023,
Номер
23(1)
Опубликована: Окт. 20, 2023
Older
adults
living
with
dementia
may
express
challenging
responsive
behaviours.
One
management
strategy
is
pharmacologic
treatment
though
these
options
often
have
limited
benefit,
which
lead
to
multiple
treatments
being
prescribed.The
aim
of
the
present
study
was
describe
psychoactive
medication
polypharmacy
and
explore
factors
associated
in
a
cohort
older
Nova
Scotia,
Canada,
including
gender-stratified
analysis.
This
retrospective
those
aged
65
years
or
recorded
diagnosis
between
2005
2015.
Medication
dispensation
data
collected
from
April
1,
2010,
(cohort
entry)
either
death
March
31,
2015
exit).
Psychoactive
claims
were
captured.
defined
as
presence
three
more
prescription
medications
dispensed
one
subject
overlapping
for
than
30
days.
episodes
described
duration,
quantity,
implicated
medications.
Regression
analysis
examined
experience
frequency
polypharmacy.
All
stratified
by
gender.The
included
15,819
(mean
age
80.7
years;
70.0%
female),
99.4%
(n
=
15,728)
receiving
at
least
over
period
follow-up.
19.3%
cohort.
The
gender
specific
logistic
regressions
demonstrated
that
both
men
women
younger
an
increased
risk
(women:
OR
0.97,
95%CI[0.96,
0.98],
men:
0.96,
95%CI[0.95,
0.97]).
Men
less
likely
if
their
location
residence
urban
(OR
0.86,
95%CI[0.74,
0.99]).
There
no
significant
association
(urban
rural)
dementia.
Antidepressants
most
class,
while
quetiapine
medication.This
suggests
ages
rural
locations
benefit
access
non-pharmacological
management.
Язык: Английский
An investigation of psychoactive polypharmacy and related gender-differences in older adults with dementia: A retrospective cohort study
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 3, 2023
Abstract
Background:
Older
adults
with
dementia
may
express
challenging
responsive
behaviours.
One
management
strategy
is
pharmacologic
treatment
though
these
options
have
limited
benefit.
The
benefit
lead
to
multiple
treatments
being
prescribed.
Methods:
aim
of
the
present
study
was
describe
psychoactive
medication
polypharmacy
and
explore
factors
associated
in
a
cohort
older
Nova
Scotia,
Canada,
including
gender-stratified
analysis.
This
retrospective
those
aged
65
years
or
recorded
diagnosis
between
2005
2015.
Medication
dispensation
data
collected
from
April
1,
2010,
(cohort
entry)
either
death
March
31,
2015
exit).
Psychoactive
claims
were
captured.
defined
as
presence
three
more
prescription
medications
dispensed
one
subject
overlapping
for
than
30
days.
episodes
described
duration,
quantity,
implicated
medications.
Regression
analysis
examined
experience
frequency
polypharmacy.
All
stratified
by
gender.
Results:
included
15,819
(mean
age
80.7
years;
70.0%
female),
54.3%
(n
=
15,728)
receiving
at
least
medication.
19.3%
met
definition
Logistic
regression
adjusted
diagnosis,
year
rural
urban
location
residence
demonstrated
both
men
women
that
younger
increased
risk
(women:
OR
0.97,
95%CI[0.96,
0.98],
men:
0.96,
95%CI[0.95,
0.97]).
Men
less
likely
if
their
(OR
0.86,
95%CI[0.74,
0.99]),
but
there
no
significant
association
(urban
rural)
dementia.
Antidepressants
most
class,
while
quetiapine
Conclusions:
suggests
are
living
locations
access
non-pharmacological
management.
Язык: Английский