Technology in Cancer Research & Treatment,
Год журнала:
2024,
Номер
23
Опубликована: Янв. 1, 2024
Background
Gastric
intestinal
metaplasia(GIM)
is
an
independent
risk
factor
for
GC,
however,
its
pathogenesis
still
unclear.
Ferroptosis
a
new
type
of
programmed
cell
death,
which
may
be
involved
in
the
process
GIM.
The
purpose
this
study
was
to
analyze
expression
ferroptosis-related
genes
(FRGs)
GIM
tissues
and
explore
relationship
between
ferroptosis
Method
results
tissue
full
transcriptome
sequencing
were
downloaded
from
Gene
Expression
Omnibus(GEO)
database.
R
software
(V4.2.0)
packages
used
screening
enrichment
analysis
differentially
expressed
genes(DEGs).
key
screened
by
least
absolute
shrinkage
selection
operator(LASSO)
support
vector
machine-recursive
feature
elimination(SVM-RFE)
algorithm.
Receiver
operating
characteristic(ROC)
curve
evaluate
diagnostic
efficacy
Clinical
samples
further
validate
hub
genes.
Results
A
total
12
(DEFRGs)
identified.
Using
two
machine
learning
algorithms,
GOT1,
ALDH3A2,
ACSF2
SESN2
identified
as
area
under
ROC
(AUC)
training
set
0.906,
0.955,
0.899
0.962
respectively,
AUC
verification
0.776,
0.676,
0.773
0.880,
respectively.
verified
differential
ACSF2,
Conclusion
We
found
that
there
significant
correlation
can
markers
effectively
identify
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114993 - 114993
Опубликована: Июнь 9, 2023
Cardiovascular
disease
(CVD)
is
a
major
contributor
to
increasing
morbidity
and
mortality
worldwide
seriously
threatens
human
health
life.
Cardiomyocyte
death
considered
the
pathological
basis
of
various
CVDs,
including
myocardial
infarction,
heart
failure,
aortic
dissection.
Multiple
mechanisms,
such
as
ferroptosis,
necrosis,
apoptosis,
contribute
cardiomyocyte
death.
Among
them,
ferroptosis
an
iron-dependent
form
programmed
cell
that
plays
vital
role
in
physiological
processes,
from
development
aging
immunity
CVD.
The
dysregulation
has
been
shown
be
closely
associated
with
CVD
progression,
yet
its
underlying
mechanisms
are
still
not
fully
understood.
In
recent
years,
growing
amount
evidence
suggests
non-coding
RNAs
(ncRNAs),
particularly
microRNAs,
long
RNAs,
circular
involved
regulation
thus
affecting
progression.
Some
ncRNAs
also
exhibit
potential
value
biomarker
and/or
therapeutic
target
for
patients
this
review,
we
systematically
summarize
findings
on
their
We
focus
clinical
applications
diagnostic
prognostic
biomarkers
well
targets
treatment.
DATA
AVAILABILITY:
No
new
data
were
created
or
analyzed
study.
Data
sharing
applicable
article.
Cancer
poses
intricate
challenges
to
treatment
due
its
complexity
and
diversity.
Ferroptosis
circular
RNAs
(circRNAs)
are
emerging
as
innovative
therapeutic
avenues
amid
the
evolving
landscape
of
cancer
therapy.
Extensive
investigations
into
circRNAs
reveal
their
diverse
roles,
ranging
from
molecular
regulators
pivotal
influencers
ferroptosis
in
cell
lines.
The
results
underscore
significance
modulating
pathways
that
impact
crucial
aspects
development,
including
survival,
proliferation,
metastasis.
A
detailed
analysis
delineates
these
pathways,
shedding
light
on
mechanisms
through
which
influence
ferroptosis.
Building
upon
recent
experimental
findings,
study
evaluates
potential
targeting
induce
By
identifying
specific
associated
with
etiology
cancer,
this
paves
way
for
development
targeted
therapeutics
exploit
vulnerabilities
cells.
This
review
consolidates
existing
understanding
circRNAs,
emphasizing
role
therapy
providing
impetus
ongoing
research
dynamic
field.
See
also
graphical
abstract(Fig.
1).
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2024,
Номер
150(2)
Опубликована: Фев. 26, 2024
Abstract
Purpose
Helicobacter
pylori
(
H.
)
has
unique
biochemical
traits
and
pathogenic
mechanisms,
which
make
it
a
substantial
cause
of
gastrointestinal
cancers.
Circular
RNAs
(circRNAs)
have
concurrently
been
identified
as
an
important
participating
factor
in
the
pathophysiology
several
different
However,
underlying
processes
putative
interactions
between
circRNAs
received
very
little
attention.
To
address
this
issue,
we
explored
interaction
to
investigate
how
they
might
jointly
contribute
occurrence
development
gastric
cancer.
Methods
Changes
circPGD
expression
were
detected
using
qRT-PCR.
Cell
proliferation
migration
changes
assayed
by
colony
formation,
CCK-8
assay
transwell
assay.
Apoptosis
was
measured
flow
cytometry.
Western
blot
conducted
detect
cell
migration,
apoptosis,
inflammation-associated
proteins.
QRT-PCR
used
measure
factors.
Results
We
found
that
induced
increased
infected
human
cells
facilitated
cancer
progression
three
ways
promoting
enhancing
inflammatory
response,
inhibiting
apoptosis.
Conclusions
CircPGD
appears
play
role
-related
may
thus
be
viable,
novel
target
for
therapeutic
intervention.
