Cancer Studies and Molecular Medicine - Open Journal,
Год журнала:
2023,
Номер
8(1), С. 4 - 9
Опубликована: Дек. 29, 2023
Endometrial
cancer
(EC)
is
the
most
common
malignant
tumor
in
post-menopausal
women,
and
lung
one
of
organs
to
which
endometrial
adenocarcinoma
metastasizes.
Chemotherapy
helpful
for
various
malignancies,
but
not
all
are
successful.
A
71-year-old-Japanese-woman
was
diagnosed
with
metastatic
stage
IV
primary
adenocarcinoma.
She
received
chemotherapy
hormone
therapy
after
a
total
hysterectomy
pelvic
lymphadenectomy.
Subsequently,
she
visited
this
clinic
second
opinion
as
had
repeated
remissions
recurrences.
Here,
authors
report
case
complete
remission
achieved
by
using
product
containing
low
molecular
weight
fucoidan
extract
(LMF)
Canavalia
gladiata
(CG)
(LMF-CG)
combination
Medroxyprogesterone
acetate
(MPA)
therapy.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(18), С. 10479 - 10479
Опубликована: Сен. 9, 2022
In
recent
years,
interest
in
natural
products
such
as
alternative
sources
of
pharmaceuticals
for
numerous
chronic
diseases,
including
tumors,
has
been
renewed.
Propolis,
a
product
collected
by
honeybees,
and
polyphenolic/flavonoid
propolis-related
components
modulate
all
steps
the
cancer
progression
process.
Anticancer
activity
propolis
its
compounds
relies
on
various
mechanisms:
cell-cycle
arrest
attenuation
cells
proliferation,
reduction
number
stem
cells,
induction
apoptosis,
modulation
oncogene
signaling
pathways,
inhibition
matrix
metalloproteinases,
prevention
metastasis,
anti-angiogenesis,
anti-inflammatory
effects
accompanied
tumor
microenvironment
(by
modifying
macrophage
activation
polarization),
epigenetic
regulation,
antiviral
bactericidal
activities,
gut
microbiota,
chemotherapy-induced
deleterious
side
effects.
Ingredients
from
also
”sensitize“
to
chemotherapeutic
agents,
likely
blocking
transcription
factor
nuclear
kappa-light-chain-enhancer
activated
B
(NF-κB).
this
review,
we
summarize
current
knowledge
related
flavonoids
other
polyphenolic
growth
metastasizing
ability,
discuss
possible
molecular
cellular
mechanisms
involved
inflammatory
pathways
processes
that
affect
survival,
invasion,
angiogenesis,
metastasis
tumor.
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2025,
Номер
6
Опубликована: Янв. 3, 2025
Cancer
is
the
greatest
cause
of
mortality
worldwide.
Various
drug
classes
treat
various
cancers.
Nanoformulations
made
from
natural
sources
are
being
studied
for
treating
several
diseases,
including
cancer.
Surgery,
chemotherapy,
immunotherapy,
and
radiation
have
mostly
failed
to
These
drugs
may
damage
quickly
dividing
healthy
tissues,
structural
anomalies,
bodily
toxicity,
long-term
side
effects,
tumor
cell
resistance,
psychiatric
disturbances.
Researchers
developing
nanoscale
medicines
using
medications
like
Malva
sylvestris
Curcumin
lower
concentrations
improve
target
specificity.
Nanoparticles'
small
size
unique
properties
make
them
beneficial.
They
encapsulate
medicinal
ingredients,
improving
solubility,
medication
release,
cellular
absorption,
delivery.
Nanoparticles
better
identify
bind
cancer
cells
when
functionalized
with
ligands.
Natural
chemicals
nanotechnology
availability,
distribution,
targeting
cells,
making
treatments
more
effective
safe.
Nanomedicine,
which
employs
nanoparticles
malignant
has
grown
rapidly
because
nanodrugs
fewer
effects
than
current
commercial
drugs.
Nanotechnology-based
pharmaceutical
delivery
methods
therapy
covered
in
this
review
article.
The
paper
discusses
nanoparticle
pros
cons
chemicals'
cancer-fighting
appeal.
Frontiers in Education,
Год журнала:
2025,
Номер
9
Опубликована: Янв. 1, 2025
Background
Childhood
is
a
critical
developmental
stage,
especially
for
children
with
special
educational
needs
(SEN),
as
it
can
profoundly
affect
their
development
and
future
well-being.
Purpose
To
assess
the
state
of
research
on
inclusive
education
SEN
over
last
10
years,
1,024
documents
from
Web
Science
(WoS)
core
collection
were
analyzed.
Methods
Using
CiteSpace,
comprehensive
analysis
included
an
overview
field,
keyword
distribution,
foci,
emerging
trends.
Results
conclusions
This
study
identified
that
in
primarily
concentrates
education,
psychology,
SEN.
Furthermore,
must
involve
sociology,
medicine,
rehabilitation,
public
policy
law,
neuroscience,
family
studies.
Primary
questions
should
address
effectiveness
learning
outcomes
SEN,
social
emotional
development,
support
participation
practice,
professional
training
teachers.
We
expect
will
become
more
multidimensional
comprehensive.
The
focus
shift
toward
comparative
studies
history
peers.
Methodologically,
integration
quantitative
qualitative
approaches
essential.
From
perspective,
stronger
emphasis
be
cross-national
Moreover,
interdisciplinary
collaboration
increased
to
enrich
theoretical
knowledge
system
children,
thereby
providing
robust
evidence
base
practices.
Drug Delivery,
Год журнала:
2022,
Номер
29(1), С. 3052 - 3070
Опубликована: Сен. 22, 2022
Dihydromyricetin
(DHM)
is
an
important
natural
flavonoid
that
has
attracted
much
attention
because
of
its
various
functions
such
as
protecting
the
cardiovascular
system
and
liver,
treating
cancer
neurodegenerative
diseases,
anti-inflammation
effect,
etc.
Despite
great
development
potential
in
pharmacy,
DHM
some
problems
pharmaceutical
applications
low
solubility,
permeability,
stability.
To
settle
these
issues,
extensive
research
been
carried
out
on
physicochemical
properties
dosage
forms
to
produce
all
kinds
preparations
past
ten
years.
In
addition,
combined
use
with
other
drugs
a
promising
strategy
expand
application
DHM.
However,
although
invention
patents
for
have
issued
several
countries,
current
transformation
results
into
market
products
insufficient.
date,
there
still
lack
deep
pharmacokinetics,
pharmacodynamics,
toxicology,
action
mechanism
preparations.
Besides,
therapy
are
scarcely
reported,
which
necessitates
this
application.
Apart
from
medicine,
food
industry
also
potential.
Due
multiple
effects
excellent
safety,
can
be
developed
functional
drinks
foods.
Through
review,
we
hope
draw
more
above
challenges
provide
valuable
references
similar
structure-activity
relationship
drug.
Molecules,
Год журнала:
2022,
Номер
27(24), С. 8641 - 8641
Опубликована: Дек. 7, 2022
Worldwide,
the
incidence
of
cancer
is
on
rise.
Current
treatments
include
chemotherapy,
radiation
therapy,
and
surgery.
Chemotherapy
treatment
are
typically
associated
with
severe
adverse
effects
a
decline
in
patients’
quality
life.
Anti-cancer
substances
derived
from
plants
animals
need
to
be
evaluated
therapeutically
as
it
cost-effective,
have
fewer
side
effects,
can
improve
Recently,
bovine
colostrum
(BC)
has
attracted
interest
numerous
researchers
investigating
its
anti-cancer
potential
humans.
Dressings
loaded
BC
beneficial
treating
chronic
wounds
diabetic
foot
ulcers.
Lactoferrin,
glycoprotein
potent
anti-oxidant,
anti-inflammatory,
anti-cancer,
anti-microbial
abundant
BC.
The
pills
successfully
promote
regression
low-grade
cervical
intraepithelial
neoplasia
when
administered
intravaginally.
biological,
genetic,
molecular
mechanisms
driving
remain
determined.
Oral
supplements
generally
well-tolerated,
but
some
flatulence
nausea
may
happen.
To
evaluate
therapeutic
long-term
safety,
appropriate
dosages
drugs,
well-designed
clinical
trials
necessary.
purpose
this
article
emphasize
constituents.
Menthol,
a
cyclic
monoterpene
alcohol
commonly
derived
from
mint
essential
oils,
is
widely
utilized
across
the
pharmaceutical,
cosmetic,
and
personal
care
industries
due
to
its
cooling,
analgesic,
aromatic
properties.
This
study
presents
comprehensive
patent
landscape
analysis
of
organic
menthol
crystals
their
derivatives,
with
focus
on
identifying
current
trends
emerging
applications.
Patent
data
were
retrieved
The
Lens
Google
Patents,
23,515
relevant
patents
analyzed
using
international
classification
codes.
results
revealed
significant
applications
in
pharmaceuticals,
care,
drug
delivery
systems,
notable
innovations
controlled-release
formulations,
cancer
treatments,
pain
relief
products.
Emerging
include
combination
other
natural
compounds,
advances
microencapsulation
for
controlled
delivery,
use
as
flavor
enhancement
tobacco
industry.
United
States
leads
menthol-related
patents,
followed
by
China
European
Union.
provides
valuable
insights
into
future
applications,
suggesting
that
role
therapeutic
cosmetic
will
continue
grow,
driven
technological
advancements
regulatory
factors.
