Herbal based nanoparticles as a possible and potential treatment of cancer: a review

Exploration of Targeted Anti-tumor Therapy, Journal Year: 2025, Volume and Issue: 6

Published: Jan. 3, 2025

Cancer is the greatest cause of mortality worldwide. Various drug classes treat various cancers. Nanoformulations made from natural sources are being studied for treating several diseases, including cancer. Surgery, chemotherapy, immunotherapy, and radiation have mostly failed to These drugs may damage quickly dividing healthy tissues, structural anomalies, bodily toxicity, long-term side effects, tumor cell resistance, psychiatric disturbances. Researchers developing nanoscale medicines using medications like Malva sylvestris Curcumin lower concentrations improve target specificity. Nanoparticles' small size unique properties make them beneficial. They encapsulate medicinal ingredients, improving solubility, medication release, cellular absorption, delivery. Nanoparticles better identify bind cancer cells when functionalized with ligands. Natural chemicals nanotechnology availability, distribution, targeting cells, making treatments more effective safe. Nanomedicine, which employs nanoparticles malignant has grown rapidly because nanodrugs fewer effects than current commercial drugs. Nanotechnology-based pharmaceutical delivery methods therapy covered in this review article. The paper discusses nanoparticle pros cons chemicals' cancer-fighting appeal.

Language: Английский

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Molecular and Cellular Mechanisms of Propolis and Its Polyphenolic Compounds against Cancer

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(18), P. 10479 - 10479

Published: Sept. 9, 2022

In recent years, interest in natural products such as alternative sources of pharmaceuticals for numerous chronic diseases, including tumors, has been renewed. Propolis, a product collected by honeybees, and polyphenolic/flavonoid propolis-related components modulate all steps the cancer progression process. Anticancer activity propolis its compounds relies on various mechanisms: cell-cycle arrest attenuation cells proliferation, reduction number stem cells, induction apoptosis, modulation oncogene signaling pathways, inhibition matrix metalloproteinases, prevention metastasis, anti-angiogenesis, anti-inflammatory effects accompanied tumor microenvironment (by modifying macrophage activation polarization), epigenetic regulation, antiviral bactericidal activities, gut microbiota, chemotherapy-induced deleterious side effects. Ingredients from also ”sensitize“ to chemotherapeutic agents, likely blocking transcription factor nuclear kappa-light-chain-enhancer activated B (NF-κB). this review, we summarize current knowledge related flavonoids other polyphenolic growth metastasizing ability, discuss possible molecular cellular mechanisms involved inflammatory pathways processes that affect survival, invasion, angiogenesis, metastasis tumor.

Language: Английский

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Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

Drug Delivery, Journal Year: 2022, Volume and Issue: 29(1), P. 3052 - 3070

Published: Sept. 22, 2022

Dihydromyricetin (DHM) is an important natural flavonoid that has attracted much attention because of its various functions such as protecting the cardiovascular system and liver, treating cancer neurodegenerative diseases, anti-inflammation effect, etc. Despite great development potential in pharmacy, DHM some problems pharmaceutical applications low solubility, permeability, stability. To settle these issues, extensive research been carried out on physicochemical properties dosage forms to produce all kinds preparations past ten years. In addition, combined use with other drugs a promising strategy expand application DHM. However, although invention patents for have issued several countries, current transformation results into market products insufficient. date, there still lack deep pharmacokinetics, pharmacodynamics, toxicology, action mechanism preparations. Besides, therapy are scarcely reported, which necessitates this application. Apart from medicine, food industry also potential. Due multiple effects excellent safety, can be developed functional drinks foods. Through review, we hope draw more above challenges provide valuable references similar structure-activity relationship drug.

Language: Английский

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A review of research on the development of inclusive education in children with special educational needs over the past 10 years: a visual analysis based on CiteSpace

Frontiers in Education, Journal Year: 2025, Volume and Issue: 9

Published: Jan. 1, 2025

Background Childhood is a critical developmental stage, especially for children with special educational needs (SEN), as it can profoundly affect their development and future well-being. Purpose To assess the state of research on inclusive education SEN over last 10 years, 1,024 documents from Web Science (WoS) core collection were analyzed. Methods Using CiteSpace, comprehensive analysis included an overview field, keyword distribution, foci, emerging trends. Results conclusions This study identified that in primarily concentrates education, psychology, SEN. Furthermore, must involve sociology, medicine, rehabilitation, public policy law, neuroscience, family studies. Primary questions should address effectiveness learning outcomes SEN, social emotional development, support participation practice, professional training teachers. We expect will become more multidimensional comprehensive. The focus shift toward comparative studies history peers. Methodologically, integration quantitative qualitative approaches essential. From perspective, stronger emphasis be cross-national Moreover, interdisciplinary collaboration increased to enrich theoretical knowledge system children, thereby providing robust evidence base practices.

Language: Английский

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Unlocking the biological potential of crebanine, oxocrebanine and dehydrocrebanine: Pharmacological activity and related molecular mechanisms

Fitoterapia, Journal Year: 2025, Volume and Issue: 182, P. 106467 - 106467

Published: March 7, 2025

Language: Английский

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Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(2), P. 287 - 306

Published: March 25, 2024

Language: Английский

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Research progress of small-molecule drugs in targeting telomerase in human cancer and aging

Chemico-Biological Interactions, Journal Year: 2023, Volume and Issue: 382, P. 110631 - 110631

Published: July 13, 2023

Language: Английский

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Bovine Colostrum Treatment of Specific Cancer Types: Current Evidence and Future Opportunities

Molecules, Journal Year: 2022, Volume and Issue: 27(24), P. 8641 - 8641

Published: Dec. 7, 2022

Worldwide, the incidence of cancer is on rise. Current treatments include chemotherapy, radiation therapy, and surgery. Chemotherapy treatment are typically associated with severe adverse effects a decline in patients’ quality life. Anti-cancer substances derived from plants animals need to be evaluated therapeutically as it cost-effective, have fewer side effects, can improve Recently, bovine colostrum (BC) has attracted interest numerous researchers investigating its anti-cancer potential humans. Dressings loaded BC beneficial treating chronic wounds diabetic foot ulcers. Lactoferrin, glycoprotein potent anti-oxidant, anti-inflammatory, anti-cancer, anti-microbial abundant BC. The pills successfully promote regression low-grade cervical intraepithelial neoplasia when administered intravaginally. biological, genetic, molecular mechanisms driving remain determined. Oral supplements generally well-tolerated, but some flatulence nausea may happen. To evaluate therapeutic long-term safety, appropriate dosages drugs, well-designed clinical trials necessary. purpose this article emphasize constituents.

Language: Английский

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Superparamagnetic iron oxide nanoparticles functionalized by biocompatible ligands with enhanced high specific absorption rate for magnetic hyperthermia

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 693, P. 134036 - 134036

Published: April 26, 2024

Language: Английский

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Patent Landscape and Applications of Organic Menthol Crystals: An In-Depth Analysis of Emerging Trends and Industrial Applications

Published: Nov. 28, 2024

Menthol, a cyclic monoterpene alcohol commonly derived from mint essential oils, is widely utilized across the pharmaceutical, cosmetic, and personal care industries due to its cooling, analgesic, aromatic properties. This study presents comprehensive patent landscape analysis of organic menthol crystals their derivatives, with focus on identifying current trends emerging applications. Patent data were retrieved The Lens Google Patents, 23,515 relevant patents analyzed using international classification codes. results revealed significant applications in pharmaceuticals, care, drug delivery systems, notable innovations controlled-release formulations, cancer treatments, pain relief products. Emerging include combination other natural compounds, advances microencapsulation for controlled delivery, use as flavor enhancement tobacco industry. United States leads menthol-related patents, followed by China European Union. provides valuable insights into future applications, suggesting that role therapeutic cosmetic will continue grow, driven technological advancements regulatory factors.

Language: Английский

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