Breast
cancer
is
one
of
the
most
common
types
malignancy
diagnosed
among
females
worldwide.
Due
to
its
heterogenous
nature,
type
treatment
be
decided
a
very
crucial
thing
treat
disease.
Chemotherapy
has
become
mainstay
breast
treatment.
The
increased
understanding
made
it
possible
develop
more
intelligent
therapies
that
could
effectively
target
disease
and
react
milieu.
This
was
by
advancements
in
molecular
biology
pharmacology.
two
important
predominant
physiological
processes
tissue
homeostasis
are
mammalian
cell
division
death.
Dysregulated
cycle
main
hallmarks
any
kind
cancer,
including
cancer.
Among
various
regulators
cycle,
cyclin-dependent
kinases
play
major
role
regulation.
CDKs
along
with
their
cyclin
partners
studies.
dysregulated
CDK
expression
BC
patients
affected
both
overall
survival
(OS)
relapse-free
(RFS).
Studies
on
enrichment
demonstrated
importance
neoplastic
suggested
regulating
conjunction
traditional
medications
might
promising
option
patients.
Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
30(7), С. 103705 - 103705
Опубликована: Июнь 15, 2023
Breast
cancer
is
the
leading
cause
of
death
among
women
worldwide.
Despite
recent
treatment
options
like
surgery,
chemotherapy
etc.
lethality
breast
alarming.
Natural
compounds
are
considered
a
better
option
against
carcinoma
because
their
lower
side
effects
and
specificity
in
targeting
important
proteins
involved
aberrant
activation
pathways
cancer.
A
recently
discovered
compound
called
Juglanthraquinone
C,
which
found
bark
Juglans
mandshurica
Maxim
(Juglandaceae)
tree
has
shown
promising
cytotoxicity
hepatocellular
carcinoma.
However,
not
much
data
available
on
molecular
mechanisms
followed
by
this
compound.
Therefore,
we
aimed
to
investigate
mechanism
C
We
used
network
pharmacology
technique
analyse
action
validated
our
study
applying
various
computational
tools
such
as
UALCAN,
cBioportal,
TIMER,
docking
simulation.
The
results
showed
target
shared
31
common
targets.
Moreover,
observed
that
targets
multiple
deregulated
genes
TP53,
TGIF1,
IGF1R,
SMAD3,
JUN,
CDC42,
HBEGF,
FOS
signaling
PI3K-Akt
pathway,
TGF-β
MAPK
pathway
HIPPO
pathway.
examination
revealed
investigated
drug
had
high
affinity
for
primary
TGIF1
protein.
stable
protein-ligand
combination
was
generated
best
hit
molecule,
according
dynamics
modeling.
main
aim
examine
C's
significance
prospective
understand
substance
uses
since
there
need
discover
new
therapeutics
decrease
load
current
also
currently
ineffective
due
several
development
resistance.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Янв. 31, 2024
P66Shc
and
Rac1
proteins
are
responsible
for
tumor-associated
inflammation,
particularly
in
brain
tumors
characterized
by
elevated
oxidative
stress
increased
reactive
oxygen
species
(ROS)
production.
Quercetin,
a
natural
polyphenolic
flavonoid,
is
well-known
redox
modulator
with
anticancer
properties.
It
has
the
capacity
to
cross
blood–brain
barrier
and,
thus,
could
be
possible
drug
against
tumors.
In
this
study,
we
explored
effect
of
quercetin
on
Rac1/p66Shc-mediated
tumor
cell
which
principal
pathway
generation
ROS
cells.
Glioma
cells
transfected
Rac1,
p66Shc,
or
both
were
treated
varying
concentrations
different
time
points.
Quercetin
significantly
reduced
viability
migration
an
ROS-dependent
manner
concomitant
inhibition
Rac1/p66Shc
expression
production
naïve
Rac1/p66Shc-transfected
lines,
suggestive
preventing
activation.
Through
molecular
docking
simulations,
observed
that
showed
best
binding
compared
other
known
inhibitors
specifically
blocked
GTP-binding
site
A-loop
prevent
GTP
We
conclude
exerts
its
effects
via
modulation
Rac1-p66Shc
signaling
inhibiting
activation,
thus
restraining
growth.
Saudi Journal of Biological Sciences,
Год журнала:
2024,
Номер
31(3), С. 103935 - 103935
Опубликована: Янв. 21, 2024
Cancer
of
the
breast
is
mainly
prevalent
class
cancer
in
females
diagnosed
over
globe.
It
also
happens
to
be
2nd
most
reason
cancer-related
deaths
among
worldwide.
Some
common
type's
therapies
for
carcinoma
involve
radiation
therapy,
chemotherapy,
and
resection.
Many
studies
are
being
conducted
develop
new
therapeutic
strategies
better
diagnosis
cancer.
An
enormous
number
anticancer
medications
have
been
developed
as
a
result
growing
understanding
molecular
pathways
behind
advancement
Over
past
few
decades,
general
survival
rate
has
not
greatly
increased
due
usage
chemically
manufactured
medications.
Therefore,
order
increase
effectiveness
current
treatments,
tactics
cutting-edge
chemoprevention
drugs
required.
Phytochemicals,
which
naturally
occurring
molecules
derived
from
plants,
important
sources
both
therapy
innovative
medication
development.
These
phytochemicals
frequently
work
by
controlling
linked
development
spread
Increasing
antioxidant
status,
inactivating
carcinogens,
preventing
proliferation,
causing
cell
cycle
arrest
apoptosis,
immune
system
control
some
specific
ways.
This
primary
objective
this
review
provide
an
overview
active
ingredients
found
natural
goods,
including
information
on
their
pharmacologic
action,
targets,
state
knowledge.
We
given
thorough
description
substances
that
specifically
target
study.
We've
great
deal
study
compounds
may
help
us
identify
novel
targets
detection
carcinoma.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 326 - 326
Опубликована: Март 1, 2024
SMADs
are
the
canonical
intracellular
effector
proteins
of
TGF-β
(transforming
growth
factor-β).
translocate
from
plasma
membrane
receptors
to
nucleus
regulated
by
many
SMAD-interacting
through
phosphorylation
and
other
post-translational
modifications
that
govern
their
nucleocytoplasmic
shuttling
subsequent
transcriptional
activity.
The
signaling
pathway
TGF-β/SMAD
exhibits
both
tumor-suppressing
tumor-promoting
phenotypes
in
epithelial-derived
solid
tumors.
Collectively,
pleiotropic
nature
presents
significant
challenges
for
development
effective
cancer
therapies.
Here,
we
review
preclinical
studies
evaluate
efficacy
inhibitors
targeting
major
SMAD-regulating
and/or
-interacting
proteins,
particularly
enzymes
may
play
important
roles
epithelial
or
mesenchymal
compartments
within
Saudi Journal of Biological Sciences,
Год журнала:
2023,
Номер
30(12), С. 103848 - 103848
Опубликована: Окт. 21, 2023
Breast
cancer
is
the
primary
factor
contributing
to
female
mortality
worldwide.
The
incidence
has
overtaken
lung
cancer.
It
most
difficult
illness
due
its
heterogeneity
and
made
up
of
several
subtypes,
including
Luminal
A
B,
basal-like,
Her-2
overexpressed
TNBC.
Amongst
different
breast
carcinoma
TNBC
deadly
subtype.
hostile
nature
mainly
attributed
lack
three
hormonal
receptors
hence
targeted
therapy.
Furthermore,
current
diagnostic
options
like
radiotherapy,
surgery
chemotherapy
render
unsuccessful
recurrence,
treatment
side
effects
drug
resistance.
majority
anticancer
drugs
come
from
natural
sources
or
developed
them,
making
a
significant
source
many
medicines.
Marine-based
constituents
such
as
nucleotides,
proteins,
peptides,
amides
are
receiving
lot
interest
in
field
their
bioactive
properties.
role
stypoldione
this
study
prospective
for
was
examined,
we
sought
comprehend
molecular
means/pathways
chemical
employs
carcinoma.
promising
possibility
an
anti-cancer
stypoldione,
marine
produced
brown
alga
Stypopodium
zonale.
We
investigated
stypoldione's
mode
action
using
network
pharmacology
method,
confirmed
our
research
by
number
computational
tools,
UALCAN,
cBioportal,
TIMER,
docking,
simulation.
findings
revealed
92
common
targets
between
target
network.
Additionally,
found
that
unregulated
genes
cancer,
including:
ESR1,
HSP90AA1,
CXCL8,
PTGS2,
APP,
MDM2,
JAK2,
KDR,
LCK,
GRM5,
MAPK14,
KIT,
signaling
pathways
FOXO
pathway,
VEGF
calcium
MAPK/ERK
pathway
Neuroactive
ligand-receptor
interaction.
examined
medication
demonstrated
strong
affinity
major
targets,
according
docking
analysis.
best
hit
compound
stable
protein-ligand
pair,
predicted
dynamics
simulations.
Our
results
supported
fact
when
in-vitro
assays
were
done
on
melanoma
it
mechanisms
involved
PI3K/mTOR/Akt
NF-kB
pathways.
This
set
out
inspect
possible
value
cure
get
deeper
understanding
which
acts
Translational Breast Cancer Research,
Год журнала:
2024,
Номер
5, С. 33 - 33
Опубликована: Окт. 1, 2024
The
phosphatidylinositol-3-kinase
(PI3K)
signaling
plays
a
key
role
in
various
cellular
functions
and
is
frequently
activated
cancer,
making
it
an
attractive
therapeutic
target.
PI3K
pathway
influencing
glucose
metabolism,
lipid
synthesis,
nucleotide
production,
protein
all
of
which
contribute
to
cancer
cell
proliferation
survival.
It
enhances
uptake
through
the
activation
transporters
glycolysis,
while
also
promoting
synthesis
via
downstream
factors
like
mTORC1.
This
boosts
by
regulating
transcription
MYC,
activating
enzymes
for
purine
pyrimidine
production.
Additionally,
due
its
essential
growth,
target
anticancer
therapies.
However,
treatment
using
inhibitors
alone
has
limitations,
including
drug
resistance
significant
side
effects
such
as
hyperglycemia,
fatigue,
liver
dysfunction.
Clinical
trials
have
led
development
isoform-specific
reduce
toxicity.
Combining
with
other
treatments,
hormone
therapy
or
surgery,
may
improve
efficacy
minimize
effects.
Further
research
needed
fully
understand
mechanisms
individualized
approaches.
In
this
review,
we
introduce
characteristic
three
classes
PI3Ks,
discuss
regulation
metabolism
control
uptake,
