CDK Dysregulation in Breast Cancer: A Bioinformatics Analysis DOI
Manzoor Ahmad Mir,

Shazia Sofi,

Pir M. Ishfaq

et al.

Published: Jan. 1, 2023

Breast cancer is one of the most common types malignancy diagnosed among females worldwide. Due to its heterogenous nature, type treatment be decided a very crucial thing treat disease. Chemotherapy has become mainstay breast treatment. The increased understanding made it possible develop more intelligent therapies that could effectively target disease and react milieu. This was by advancements in molecular biology pharmacology. two important predominant physiological processes tissue homeostasis are mammalian cell division death. Dysregulated cycle main hallmarks any kind cancer, including cancer. Among various regulators cycle, cyclin-dependent kinases play major role regulation. CDKs along with their cyclin partners studies. dysregulated CDK expression BC patients affected both overall survival (OS) relapse-free (RFS). Studies on enrichment demonstrated importance neoplastic suggested regulating conjunction traditional medications might promising option patients.

Language: Английский

Targeting tumor microenvironment using tumor-infiltrating lymphocytes as therapeutics against tumorigenesis DOI
Hina Qayoom,

Shazia Sofi,

Manzoor Ahmad Mir

et al.

Immunologic Research, Journal Year: 2023, Volume and Issue: 71(4), P. 588 - 599

Published: April 1, 2023

Language: Английский

Citations

42
Identification and analysis of dysregulated fatty acid metabolism genes in breast cancer subtypes DOI

Umar Yousuf,

Shazia Sofi,

Aanisa Makhdoomi

et al.

Medical Oncology, Journal Year: 2022, Volume and Issue: 39(12)

Published: Oct. 12, 2022

Language: Английский

Citations

31
Mechanistic elucidation of Juglanthraquinone C targeting breast Cancer: A network Pharmacology-based investigation DOI Creative Commons
Hina Qayoom, Mustfa Alkhanani, Abdullah Almilaibary

et al.

Saudi Journal of Biological Sciences, Journal Year: 2023, Volume and Issue: 30(7), P. 103705 - 103705

Published: June 15, 2023

Breast cancer is the leading cause of death among women worldwide. Despite recent treatment options like surgery, chemotherapy etc. lethality breast alarming. Natural compounds are considered a better option against carcinoma because their lower side effects and specificity in targeting important proteins involved aberrant activation pathways cancer. A recently discovered compound called Juglanthraquinone C, which found bark Juglans mandshurica Maxim (Juglandaceae) tree has shown promising cytotoxicity hepatocellular carcinoma. However, not much data available on molecular mechanisms followed by this compound. Therefore, we aimed to investigate mechanism C We used network pharmacology technique analyse action validated our study applying various computational tools such as UALCAN, cBioportal, TIMER, docking simulation. The results showed target shared 31 common targets. Moreover, observed that targets multiple deregulated genes TP53, TGIF1, IGF1R, SMAD3, JUN, CDC42, HBEGF, FOS signaling PI3K-Akt pathway, TGF-β MAPK pathway HIPPO pathway. examination revealed investigated drug had high affinity for primary TGIF1 protein. stable protein-ligand combination was generated best hit molecule, according dynamics modeling. main aim examine C's significance prospective understand substance uses since there need discover new therapeutics decrease load current also currently ineffective due several development resistance.

Language: Английский

Citations

21
Quercetin suppresses ROS production and migration by specifically targeting Rac1 activation in gliomas DOI Creative Commons

Rafia A. Baba,

Hilal Ahmad Mir,

Taseem A. Mokhdomi

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Jan. 31, 2024

P66Shc and Rac1 proteins are responsible for tumor-associated inflammation, particularly in brain tumors characterized by elevated oxidative stress increased reactive oxygen species (ROS) production. Quercetin, a natural polyphenolic flavonoid, is well-known redox modulator with anticancer properties. It has the capacity to cross blood–brain barrier and, thus, could be possible drug against tumors. In this study, we explored effect of quercetin on Rac1/p66Shc-mediated tumor cell which principal pathway generation ROS cells. Glioma cells transfected Rac1, p66Shc, or both were treated varying concentrations different time points. Quercetin significantly reduced viability migration an ROS-dependent manner concomitant inhibition Rac1/p66Shc expression production naïve Rac1/p66Shc-transfected lines, suggestive preventing activation. Through molecular docking simulations, observed that showed best binding compared other known inhibitors specifically blocked GTP-binding site A-loop prevent GTP We conclude exerts its effects via modulation Rac1-p66Shc signaling inhibiting activation, thus restraining growth.

Language: Английский

Citations

7
Targeting breast cancer stem cells through retinoids: A new hope for treatment DOI Open Access
Nusrat Jan,

Shazia Sofi,

Hina Qayoom

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2023, Volume and Issue: 192, P. 104156 - 104156

Published: Oct. 10, 2023

Language: Английский

Citations

13
Phyto-therapeutics as anti-cancer agents in breast cancer: Pathway targeting and mechanistic elucidation DOI Creative Commons
Abdullah Almilaibary

Saudi Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 31(3), P. 103935 - 103935

Published: Jan. 21, 2024

Cancer of the breast is mainly prevalent class cancer in females diagnosed over globe. It also happens to be 2nd most reason cancer-related deaths among worldwide. Some common type's therapies for carcinoma involve radiation therapy, chemotherapy, and resection. Many studies are being conducted develop new therapeutic strategies better diagnosis cancer. An enormous number anticancer medications have been developed as a result growing understanding molecular pathways behind advancement Over past few decades, general survival rate has not greatly increased due usage chemically manufactured medications. Therefore, order increase effectiveness current treatments, tactics cutting-edge chemoprevention drugs required. Phytochemicals, which naturally occurring molecules derived from plants, important sources both therapy innovative medication development. These phytochemicals frequently work by controlling linked development spread Increasing antioxidant status, inactivating carcinogens, preventing proliferation, causing cell cycle arrest apoptosis, immune system control some specific ways. This primary objective this review provide an overview active ingredients found natural goods, including information on their pharmacologic action, targets, state knowledge. We given thorough description substances that specifically target study. We've great deal study compounds may help us identify novel targets detection carcinoma.

Language: Английский

Citations

5
Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors DOI Creative Commons

Farhana Runa,

Gabriela Ortíz-Soto, Natan Roberto de Barros

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(3), P. 326 - 326

Published: March 1, 2024

SMADs are the canonical intracellular effector proteins of TGF-β (transforming growth factor-β). translocate from plasma membrane receptors to nucleus regulated by many SMAD-interacting through phosphorylation and other post-translational modifications that govern their nucleocytoplasmic shuttling subsequent transcriptional activity. The signaling pathway TGF-β/SMAD exhibits both tumor-suppressing tumor-promoting phenotypes in epithelial-derived solid tumors. Collectively, pleiotropic nature presents significant challenges for development effective cancer therapies. Here, we review preclinical studies evaluate efficacy inhibitors targeting major SMAD-regulating and/or -interacting proteins, particularly enzymes may play important roles epithelial or mesenchymal compartments within

Language: Английский

Citations

5
Targeting PI3K in Cancer Treatment: A Comprehensive Review with Insights from Clinical Outcomes DOI
Munier Hossain, Md. Arafat Hossain

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177432 - 177432

Published: Feb. 1, 2025

Language: Английский

Citations

0
Design, synthesis and biological evaluation of novel 4-(thieno[3,2-d]pyrimidin-4-yl)morpholine derivatives as potent antitumor agents DOI
Ju Liu, Junfeng Gao, Rui Jing

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 117671 - 117671

Published: April 1, 2025

Language: Английский

Citations

0
Regulation of PI3K signaling in cancer metabolism and PI3K-targeting therapy DOI

Beinan Han,

Xiaorong Lin, Hai Hu

et al.

Translational Breast Cancer Research, Journal Year: 2024, Volume and Issue: 5, P. 33 - 33

Published: Oct. 1, 2024

The phosphatidylinositol-3-kinase (PI3K) signaling plays a key role in various cellular functions and is frequently activated cancer, making it an attractive therapeutic target. PI3K pathway influencing glucose metabolism, lipid synthesis, nucleotide production, protein all of which contribute to cancer cell proliferation survival. It enhances uptake through the activation transporters glycolysis, while also promoting synthesis via downstream factors like mTORC1. This boosts by regulating transcription MYC, activating enzymes for purine pyrimidine production. Additionally, due its essential growth, target anticancer therapies. However, treatment using inhibitors alone has limitations, including drug resistance significant side effects such as hyperglycemia, fatigue, liver dysfunction. Clinical trials have led development isoform-specific reduce toxicity. Combining with other treatments, hormone therapy or surgery, may improve efficacy minimize effects. Further research needed fully understand mechanisms individualized approaches. In this review, we introduce characteristic three classes PI3Ks, discuss regulation metabolism control uptake,

Language: Английский

Citations

3