Pharmaceuticals,
Год журнала:
2023,
Номер
16(11), С. 1586 - 1586
Опубликована: Ноя. 9, 2023
Diabetic
neuropathy
is
a
debilitating
manifestation
of
long-term
diabetes
mellitus.
The
present
study
explored
the
effects
roots
Rubia
cordifolia
L.
(R.
L.)
in
Wistar
rat
model
for
diabetic
and
possible
neuroprotective,
antidiabetic,
analgesic
mechanisms
underlying
this
effect.Rats
were
divided
into
five
experimental
groups.
An
amount
0.25%
carboxy
methyl
cellulose
(CMC)
saline
streptozotocin
(STZ)
(60
mg/kg)
was
given
to
group
1
2,
respectively.
Group
3
treated
with
STZ
glibenclamide
simultaneously
while
groups
4
5
hydroalcoholic
extract
root
R.
cordifolia,
Hot
plate
cold
allodynias
used
evaluate
pain
threshold.
antioxidant
assessed
by
measuring
Thiobarbituric
acid
reactive
substances
(TBARS),
reduced
glutathione
(GSH),
catalase
(CAT),
superoxide
dismutase
(SOD).
At
end
study,
sciatic
nerve
brain
tissues
collected
histopathological
study.
Bcl-2
proteins,
cleaved
caspase-3,
Bax
through
Western
blot
method.R.
significantly
attenuated
paw
withdrawal
tail
flick
latency
neuropathic
rats.
(p
<
0.01)
improved
levels
oxidative
stress.
It
found
decrease
blood
glucose
increase
animal
weight
cordifolia-treated
Treatment
suppressed
caspase-3
Bax:Bcl2
ratio
tissue
compared
group.
Histopathological
analysis
also
revealed
marked
improvement
architecture
loss
axons
at
higher
dose
(400
mg/kg).R.
its
antidiabetic
properties
ameliorating
apoptosis
Pharmaceuticals,
Год журнала:
2024,
Номер
17(3), С. 303 - 303
Опубликована: Фев. 27, 2024
The
literature
on
the
use
of
medicinal
plants
in
wound
healing
was
comprehensively
searched
to
obtain
and
assess
data.
data
were
procured
via
clinical
studies
that
utilized
their
compounds
vitro
vivo
for
healing.
This
review
collected
from
electronic
databases,
including
Google
Scholar,
PubMed,
Science
Direct,
Web
Science,
SciFinder,
Thesis,
Scopus,
using
search
terms
“natural
products”,
“wound
healing”,
compounds”,
along
with
keywords
“plants”,
“extracts”,
“phytochemicals”.
Results
last
decade
reveal
a
total
62
families
109
genera
plants,
have
been
studied
experimentally
both
clinically
found
effectively
promote
activity
is
related
presence
secondary
metabolites
such
as
flavonoids,
alkaloids,
saponins,
tannins,
terpenoids,
phenolic
compounds,
which
act
at
different
stages
through
mechanisms
exert
anti-inflammatory,
antimicrobial,
antioxidant
effects,
confirming
could
be
an
adequate
alternative
current
conventional
practices
treating
wounds.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
Rubia
cordifolia
is
a
well-known
plant
used
in
oriental
medicine
plant,
and
also
serves
as
the
primary
traditional
source
of
red
dyestuffs.
With
current
depletion
natural
resources
R.
cordifolia,
it
critical
to
conduct
cultivation
studies
on
cordifolia.
Here,
we
report
dynamic
growth
characteristics
secondary
metabolite
accumulation
cultivated
well
discovery
important
genes
involved
anthraquinone
biosynthesis.
The
results
showed
that
grows
better
sunny
environments
than
shaded
environments,
its
triennials
biennials,
base
biomass
concentration
components
purpurin
mollugin.
mollugin
content
suggested
30
June
15
October
fair
window
for
harvesting
possibility
specific
transition
connection
during
biosynthesis
process.
Furthermore,
sequenced
using
SMRT
technology
first
time
obtained
45,925
full-length
transcripts,
564
alternative
splicing
events,
3182
transcription
factors,
6454
SSRs,
6361
lncRNAs.
We
hypothesized
an
biosynthetic
pathway
found
280
transcripts
may
be
In
addition,
RT-qPCR
was
detect
relative
expression
levels
12
candidate
ungenes
above-
underground
parts
Above
all,
our
findings
have
crucial
implications
field
management
provide
useful
genetic
information
clarifying
potential
Metabolites,
Год журнала:
2022,
Номер
13(1), С. 39 - 39
Опубликована: Дек. 26, 2022
The
Rubia
genus
includes
major
groups
of
medicinal
plants
such
as
cordifolia,
tinctorum,
and
akane.
They
contain
anthraquinones
(AQs),
particularly
alizarin
purpurin,
which
have
pharmacological
effects
that
are
anti-inflammatory,
antioxidant,
anticancer,
hemostatic,
antibacterial,
more.
Alizarin
purpurin
been
utilized
natural
dyes
for
cotton,
silk,
wool
fabrics
since
the
dawn
time.
These
substances
used
in
cosmetics
food
industries
to
color
products.
amount
AQs
different
species
is
minimal.
In
order
produce
these
compounds,
researchers
established
cell
organ
cultures.
Investigations
conducted
into
numerous
chemical
physical
parameters
affect
biomass
accumulation
secondary
metabolites
a
cell,
callus,
hairy
root,
adventitious
root
suspension
This
article
offers
techniques
approaches
from
species.
Additionally,
it
has
emphasized
cells
can
be
grown
bioreactor
cultures
AQs.
This
study
aimed
to
develop
a
semisolid
vehicle
for
topical
delivery
of
nanoencapsulated
St.
John’s
wort
(SJW)
extract,
rich
in
hyperforin
(HP),
and
explore
its
wound-healing
potential.
Four
nanostructured
lipid
carriers
(NLCs)
were
obtained:
blank
HP-rich
SJW
extract-loaded
(HP-NLC).
They
comprised
glyceryl
behenate
(GB)
as
solid
lipid,
almond
oil
(AO),
or
borage
(BO)
representing
the
liquid
along
with
polyoxyethylene
(20)
sorbitan
monooleate
(PSMO)
(SMO)
surfactants.
The
dispersions
demonstrated
anisometric
nanoscale
particles
acceptable
size
distribution
disrupted
crystalline
structure,
providing
entrapment
capacity
higher
than
70%.
carrier
exhibiting
preferable
characteristics
(HP-NLC2)
was
gelled
Poloxamer
407
(PM407)
serve
hydrophilic
phase
bigel,
which
combination
BO
monostearate
(SMS)
organogel
added.
eight
prepared
bigels
different
proportions
(blank
nanodispersion-loaded)
characterized
rheologically
texturally
investigate
impact
hydrogel-to-oleogel
ratio.
therapeutic
potential
superior
formulation
(HP-NLC-BG2)
evaluated
vivo
on
Wistar
male
rats
through
tensile
strength
test
primary-closed
incised
wound.
Compared
commercial
herbal
control
group,
highest
tear
resistance
(7.764
±
0.13
N)
achieved
by
HP-NLC-BG2,
proving
outstanding
effect.
Frontiers in Plant Science,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 11, 2024
The
growth
and
quality
of
medicinal
plants
depend
heavily
on
environmental
variables.
Rubia
cordifolia
,
an
important
plant,
is
determined
by
the
two
main
secondary
metabolites
root,
purpurin
mollugin.
However,
their
relationship
with
factors
has
not
been
studied.
In
this
study,
mollugin
contents
R.
roots
from
different
sampling
sites
in
China
were
measured
using
ultra-high-performance
liquid
chromatography,
correlations
between
variables
analyzed.
results
showed
that
there
significant
differences
at
points.
content
ranged
0.00
to
3.03
mg
g
-1
while
0.03
10.09
.
Shanxi,
Shaanxi
Henan
border
areas
southeastern
Liaoning
was
higher.
expected
become
a
planting
area
Northeast
China.
Correlation
regression
analysis
revealed
affected
factors,
positively
correlated
longitude
latitude,
negatively
soil
nutrients.
addition,
higher
temperature
shorter
sunshine
duration
facilitated
synthesis
purpurin.
Annual
precipitation
might
be
factor
limiting
because
it
had
opposite
effects
major
metabolites.
Therefore,
study
great
significance
for
selection
improvement
field
quality.
