Cogent Public Health,
Год журнала:
2024,
Номер
11(1)
Опубликована: Май 14, 2024
Beside
the
use
of
conventional
medicines,
Zimbabweans
rely
on
native
malaria
control
and
treatment
practices.
This
mini-review
therefore
seeks
to
identify
assess
applicability
Zimbabwean
indigenous
practices
in
fight
against
malaria.
work
is
based
evaluation
literature
data
was
retrieved
from
databases
such
as
Web
Science,
Google
Scholar,
Scopus,
PubMed
Research
Gate.
Five
categories
used
were
identified
these
are
(1)
herbal
other
traditional
medicines
malaria,
(2)
environmental
indicators,
(3)
red-hot
granite
rock
water,
(4)
burning
dung
plants
deter
vectors
(5)
spiritual
faith
healers.
Beyond
practices,
an
overview
medical
pluralism,
health
decolonisation
public
presented.
It
has
been
shown
that
applicable
However,
can
be
applied
production
mosquito
coils
prevent
bites.
Additionally,
steaming
just
limited
management
fever
spirituality
no
scientific
basis
management.
Despite
application
Zimbabwe,
there
inconclusive
evidence
their
main
stream
systems.
A
comprehensive
study
should
conducted
order
scientifically
evaluate
Food Chemistry Advances,
Год журнала:
2023,
Номер
3, С. 100488 - 100488
Опубликована: Окт. 18, 2023
Recently,
significant
attention
has
been
paid
to
the
biologically
active
substances
in
plants
that
aid
preventing,
treating
or
delaying
diseases
brought
on
by
inflammatory
and
oxidative
processes.
There
is
scientific
evidence
support
use
of
plant
extracts
traditional
medicines
treat
bacterial,
protozoal,
helminthic
illnesses.
From
leaf
Vernonia
amygdalina
also,
phytochemicals
have
identified
extracted,
including
alkaloids,
tannins,
steroids,
cyanogenic
glycosides,
flavonoids,
phenolic
acids,
lignans,
xanthones,
anthraquinones,
oxalate
saponins.
This
article
provides
a
comprehensive
overview
bioactive
components
bitter
how
they
contribute
its
medicinal
properties.
Its
health
benefits;
ability
lower
cholesterol
levels,
it's
anticancer
antioxidant
properties
as
well
potential
natural
remedy
for
diabetes
are
also
discussed.
Conclusively,
underscores
significance
drinking
juice
effects
it
wellness.
International Journal of Food Properties,
Год журнала:
2024,
Номер
27(1), С. 194 - 213
Опубликована: Янв. 21, 2024
Diabetes
is
a
chronic
disease
that
has
affected
millions
of
people
worldwide.
The
current
treatments
for
diabetes,
such
as
insulin
therapy
and
oral
medications,
have
limitations,
including
adverse
effects
high
costs.
Therefore,
there
need
new
effective
diabetes.
Recent
studies
shown
plants
from
the
Chenopodiaceae
family
anti-diabetic
properties.
In
this
study,
we
identified
22
been
reported
to
These
contain
various
bioactive
compounds,
flavonoids,
alkaloids,
phenols
effects.
Some
these
compounds
can
enhance
secretion,
improve
glucose
uptake,
reduce
blood
levels.
properties
investigated
in
vitro
vivo
studies,
results
are
promising.
Several
levels
animal
models
diabetes
significantly.
Overall,
findings
study
suggest
potential
safe
treatment
options
Further
research
needed
fully
understand
plants'
mechanisms
action
safety
profile.
However,
provide
promising
avenue
developing
drugs
natural
sources.
Specifically,
I've
outlined
three
significant
mechanisms:
stimulation
enhancement
inhibition
gluconeogenesis,
all
which
attributed
found
medicinal
plants.
Plants,
Год журнала:
2024,
Номер
13(12), С. 1613 - 1613
Опубликована: Июнь 11, 2024
While
Moringa
oleifera
Lam.
is
gaining
importance
in
Africa,
especially
sub-Saharan
it
unclear
whether
research
following
the
quick
pace
of
its
development
on
continent.
Therefore,
this
article
analyzes
landscape
dealing
with
moringa
Africa.
This
systematic
review
draws
upon
299
eligible
articles
identified
through
a
search
carried
out
Web
Science
April
2023.
Research
M.
rather
recent
Africa
but
interest
increasing
among
scholars.
field
multidisciplinary
and
cross-sectoral,
literature
seems
to
focus
biological
environmental
sciences.
Moreover,
performed
mainly
South
Nigeria,
Egypt,
Ghana.
The
analysis
suggests
significant
potential
contribution
food
security
nutrition,
climate
change
mitigation/adaptation,
farming
systems
resilience,
livelihoods.
Its
versatility
diverse
applications
uses
make
particularly
interesting
for
developing
countries,
such
as
African
ones.
However,
also
underscores
some
factors
hindering
development.
there
need
strengthen
unlock
Investments
research,
innovation,
can
help
address
many
challenges
that
faces
contribute
transition
towards
sustainable
resilient
systems.
ACS Omega,
Год журнала:
2023,
Номер
8(46), С. 43617 - 43631
Опубликована: Ноя. 10, 2023
Human
pancreatic
α-amylase
(HPA),
situated
at
the
apex
of
starch
digestion
hierarchy,
is
an
attractive
therapeutic
approach
to
precisely
regulate
blood
glucose
levels,
thereby
efficiently
managing
diabetes.
Polyphenols
offer
a
natural
and
multifaceted
moderate
postprandial
sugar
spikes,
with
their
slight
modulation
in
carbohydrate
potential
secondary
benefits,
such
as
antioxidant
anti-inflammatory
effects.
Taking
into
consideration
unfavorable
side
effects
currently
available
commercial
medications,
we
aimed
study
library
polyphenols
attributed
remarkable
antidiabetic
properties
screened
most
potent
HPA
inhibitor
via
comprehensive
silico
encompassing
molecular
docking,
mechanics
generalized
Born
surface
area
solvation
(MM/GBSA)
calculation,
dynamics
(MD)
simulation,
density
functional
theory
(DFT)
study,
pharmacokinetic
followed
by
vitro
assay.
Significant
hydrogen
bonding
catalytic
triad
residues
HPA,
prominent
MM/GBSA
binding
energy
-27.03
kcal/mol,
stable
nature
protein-ligand
complex
regard
100
ns
MD
simulation
quercetin
best
inhibitor.
Additionally,
showed
strong
reactivity
substrate-binding
pocket
exhibited
favorable
considerable
inhibitory
concentration
(IC50)
57.37
±
0.9
μg/mL
against
α-amylase.
This
holds
prospects
for
inhibition
suggests
therapy
diabetes;
however,
it
imperative
conduct
further
research.
Zeitschrift für Naturforschung C,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 9, 2025
Abstract
Diabetes
mellitus
(DM)
is
a
group
of
metabolic
disorders
characterized
by
hyperglycemia
due
to
insufficient
insulin
secretion
or
action.
Contributing
factors
include
genetic
predisposition,
obesity,
family
history,
inactivity,
and
environmental
risks.
Type
2
diabetes
(T2DM),
the
most
common
form,
involves
impaired
pancreatic
β-cells,
leading
resistance.
By
2045,
it
projected
that
India
China
will
have
approximately
134.3
110.8
million
diabetic
individuals,
respectively.
Although
synthetic
drugs
are
effective
in
managing
DM,
they
often
come
with
side
effects.
Consequently,
plant-based
phytochemicals
antidiabetic
properties
gaining
attention.
Research
indicates
around
115
medicinal
plants
(MPs)
effects,
particularly
those
from
Fabaceae,
Liliaceae,
Lamiaceae
families.
Bioactive
compounds
like
alkaloids,
triterpenoids,
flavonoids,
phenolics
known
combat
DM.
Traditional
systems,
developing
countries,
offer
DM
management.
This
review
highlights
importance
MPs
their
bioactive
treating
underscores
need
for
further
research
commercialize
drugs.
Asian Journal of Pharmaceutical and Clinical Research,
Год журнала:
2025,
Номер
unknown, С. 56 - 67
Опубликована: Янв. 7, 2025
Objective:
This
study
aimed
to
identify
potential
glucokinase
activators
within
Zimbabwean
natural
products
using
virtual
screening
techniques.
Methods:
Twenty-one
compounds
filtered
from
ChEMBL
ID
3820
(pEC50
≥
8)
were
used
generate
a
pharmacophore
model,
validated
with
DUD-E
data.
The
model
screened
the
6220
in
Zimbabwe
Natural
Products
Database
(ZiNaPoD)
LigandScout.
Hit
docked
(protein
4NO7)
AutoDock
Vina
and
4
PyRx,
followed
by
adsorption,
distribution,
metabolism,
excretion
(ADME)
SwissADME.
Molecular
dynamics
simulations
conducted
on
resulting
complexes
CHARMM36m
force
field
GROMACS.
Results:
(80%
accuracy,
95%
sensitivity,
80%
specificity)
produced
149
hits,
16
of
which
had
binding
energies
≤
−8
kcal/mol
after
two
rounds
molecular
docking.
ADME
analysis
narrowed
selection
four
compounds,
ranging
−8.35
−9.82
kcal/mol.
All
demonstrated
stability
dynamic
simulations,
average
root
mean
square
deviation
(RMSD)
values
1.491
3.835
Å.
Sphenostylisin
I
Dihydroxymethyl
dihydroxybenzyl
chromanone
(DMDBC)
exhibited
highest
RMSD
1.491±2.794
Å
2.875±1.452
Å,
respectively.
They
also
low-binding
free
−30.30±0.38
−30.20±0.49
kcal/mol,
making
them
promising
targets.
Conclusion:
Four
identified,
DMDBC
showing
promise
as
candidates
for
developing
new
diabetes
treatments
due
their
stability,
favorable
binding,
absence
liver-toxic
groups.
Frontiers in Sustainable Food Systems,
Год журнала:
2025,
Номер
9
Опубликована: Фев. 19, 2025
Pholiota
nameko
(P.
nameko)
was
identified
as
an
edible
mushroom
known
for
its
abundance
of
bioactive
compounds.
Previous
studies
suggested
that
extracts
from
this
possess
antioxidant
properties
attributed
to
the
presence
phenolic
acids,
such
4-hydroxybenzoic
acid
(4-HBA)
and
cinnamic
(CA).
These
compounds
show
promise
in
potentially
ameliorating
insulin
resistance.
In
study,
highest
levels
4-HBA
CA
were
selected
six
P.
using
ultra-high-pressure
liquid
chromatography
(UHPLC)
investigate
whether
they
could
improve
glucose
uptake
resistance
induced
by
palmitate
C2C12
myotubes.
Additionally,
protein
expression
GLUT4
examined.
The
results
indicated
hot
water
extract
(PN-HW)
exhibited
total
polyphenol
content
(9.34
±
0.31
mg
GAE/g)
demonstrates
strong
free
radical
scavenging
ability
(77.4
1.1%).
Furthermore,
PN-HW
contains
notable
amounts
(4.02
0.17
mg/g
DW)
(2.01
0.09
DW).
Importantly,
cell
viability
reveals
did
not
have
a
toxic
effect
on
significantly
enhances
at
doses
25
μg/mL.
Hence,
it
might
contain
elevated
mitigating
impaired
caused
high-fat
consequently
enhancing
capacity
cells.
