Biological and bioactive components of bitter leaf (Vernonia amygdalina leaf): Insight on health and nutritional benefits. A review

Food Chemistry Advances, Journal Year: 2023, Volume and Issue: 3, P. 100488 - 100488

Published: Oct. 18, 2023

Recently, significant attention has been paid to the biologically active substances in plants that aid preventing, treating or delaying diseases brought on by inflammatory and oxidative processes. There is scientific evidence support use of plant extracts traditional medicines treat bacterial, protozoal, helminthic illnesses. From leaf Vernonia amygdalina also, phytochemicals have identified extracted, including alkaloids, tannins, steroids, cyanogenic glycosides, flavonoids, phenolic acids, lignans, xanthones, anthraquinones, oxalate saponins. This article provides a comprehensive overview bioactive components bitter how they contribute its medicinal properties. Its health benefits; ability lower cholesterol levels, it's anticancer antioxidant properties as well potential natural remedy for diabetes are also discussed. Conclusively, underscores significance drinking juice effects it wellness.

Language: Английский

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Antidiabetic medicinal plants from the Chenopodiaceae family: a comprehensive overview

International Journal of Food Properties, Journal Year: 2024, Volume and Issue: 27(1), P. 194 - 213

Published: Jan. 21, 2024

Diabetes is a chronic disease that has affected millions of people worldwide. The current treatments for diabetes, such as insulin therapy and oral medications, have limitations, including adverse effects high costs. Therefore, there need new effective diabetes. Recent studies shown plants from the Chenopodiaceae family anti-diabetic properties. In this study, we identified 22 been reported to These contain various bioactive compounds, flavonoids, alkaloids, phenols effects. Some these compounds can enhance secretion, improve glucose uptake, reduce blood levels. properties investigated in vitro vivo studies, results are promising. Several levels animal models diabetes significantly. Overall, findings study suggest potential safe treatment options Further research needed fully understand plants' mechanisms action safety profile. However, provide promising avenue developing drugs natural sources. Specifically, I've outlined three significant mechanisms: stimulation enhancement inhibition gluconeogenesis, all which attributed found medicinal plants.

Language: Английский

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Green synthesis of cobalt ferrite and Mn doped cobalt ferrite nanoparticles: Anticancer, antidiabetic and antibacterial studies

Journal of Trace Elements in Medicine and Biology, Journal Year: 2023, Volume and Issue: 80, P. 127292 - 127292

Published: Aug. 27, 2023

Language: Английский

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Research on Moringa (Moringa oleifera Lam.) in Africa

Plants, Journal Year: 2024, Volume and Issue: 13(12), P. 1613 - 1613

Published: June 11, 2024

While Moringa oleifera Lam. is gaining importance in Africa, especially sub-Saharan it unclear whether research following the quick pace of its development on continent. Therefore, this article analyzes landscape dealing with moringa Africa. This systematic review draws upon 299 eligible articles identified through a search carried out Web Science April 2023. Research M. rather recent Africa but interest increasing among scholars. field multidisciplinary and cross-sectoral, literature seems to focus biological environmental sciences. Moreover, performed mainly South Nigeria, Egypt, Ghana. The analysis suggests significant potential contribution food security nutrition, climate change mitigation/adaptation, farming systems resilience, livelihoods. Its versatility diverse applications uses make particularly interesting for developing countries, such as African ones. However, also underscores some factors hindering development. there need strengthen unlock Investments research, innovation, can help address many challenges that faces contribute transition towards sustainable resilient systems.

Language: Английский

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Antidiabetic phytochemicals: an overview of medicinal plants and their bioactive compounds in diabetes mellitus treatment

Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Abstract Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia due to insufficient insulin secretion or action. Contributing factors include genetic predisposition, obesity, family history, inactivity, and environmental risks. Type 2 diabetes (T2DM), the most common form, involves impaired pancreatic β-cells, leading resistance. By 2045, it projected that India China will have approximately 134.3 110.8 million diabetic individuals, respectively. Although synthetic drugs are effective in managing DM, they often come with side effects. Consequently, plant-based phytochemicals antidiabetic properties gaining attention. Research indicates around 115 medicinal plants (MPs) effects, particularly those from Fabaceae, Liliaceae, Lamiaceae families. Bioactive compounds like alkaloids, triterpenoids, flavonoids, phenolics known combat DM. Traditional systems, developing countries, offer DM management. This review highlights importance MPs their bioactive treating underscores need for further research commercialize drugs.

Language: Английский

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VIRTUAL SCREENING OF THE ZIMBABWE NATURAL PRODUCT DATABASE FOR GLUCOKINASE ACTIVATORS

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 56 - 67

Published: Jan. 7, 2025

Objective: This study aimed to identify potential glucokinase activators within Zimbabwean natural products using virtual screening techniques. Methods: Twenty-one compounds filtered from ChEMBL ID 3820 (pEC50 ≥ 8) were used generate a pharmacophore model, validated with DUD-E data. The model screened the 6220 in Zimbabwe Natural Products Database (ZiNaPoD) LigandScout. Hit docked (protein 4NO7) AutoDock Vina and 4 PyRx, followed by adsorption, distribution, metabolism, excretion (ADME) SwissADME. Molecular dynamics simulations conducted on resulting complexes CHARMM36m force field GROMACS. Results: (80% accuracy, 95% sensitivity, 80% specificity) produced 149 hits, 16 of which had binding energies ≤ −8 kcal/mol after two rounds molecular docking. ADME analysis narrowed selection four compounds, ranging −8.35 −9.82 kcal/mol. All demonstrated stability dynamic simulations, average root mean square deviation (RMSD) values 1.491 3.835 Å. Sphenostylisin I Dihydroxymethyl dihydroxybenzyl chromanone (DMDBC) exhibited highest RMSD 1.491±2.794 Å 2.875±1.452 Å, respectively. They also low-binding free −30.30±0.38 −30.20±0.49 kcal/mol, making them promising targets. Conclusion: Four identified, DMDBC showing promise as candidates for developing new diabetes treatments due their stability, favorable binding, absence liver-toxic groups.

Language: Английский

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Stimulation of glucose uptake by edible Pholiota nameko (T.Itô) S.Ito & S.Imai extract counteracts palmitate-induced insulin resistance in C2C12 myotubes

Frontiers in Sustainable Food Systems, Journal Year: 2025, Volume and Issue: 9

Published: Feb. 19, 2025

Pholiota nameko (P. nameko) was identified as an edible mushroom known for its abundance of bioactive compounds. Previous studies suggested that extracts from this possess antioxidant properties attributed to the presence phenolic acids, such 4-hydroxybenzoic acid (4-HBA) and cinnamic (CA). These compounds show promise in potentially ameliorating insulin resistance. In study, highest levels 4-HBA CA were selected six P. using ultra-high-pressure liquid chromatography (UHPLC) investigate whether they could improve glucose uptake resistance induced by palmitate C2C12 myotubes. Additionally, protein expression GLUT4 examined. The results indicated hot water extract (PN-HW) exhibited total polyphenol content (9.34 ± 0.31 mg GAE/g) demonstrates strong free radical scavenging ability (77.4 1.1%). Furthermore, PN-HW contains notable amounts (4.02 0.17 mg/g DW) (2.01 0.09 DW). Importantly, cell viability reveals did not have a toxic effect on significantly enhances at doses 25 μg/mL. Hence, it might contain elevated mitigating impaired caused high-fat consequently enhancing capacity cells.

Language: Английский

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Deciphering the the molecular mechanism of aloe-emodin in managing type II diabetes mellitus using network pharmacology, molecular docking, and molecular dynamics simulation approaches

In Silico Pharmacology, Journal Year: 2025, Volume and Issue: 13(1)

Published: March 15, 2025

Language: Английский

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From Nature to Healing: How Gynura cusimbua May Support Diabetic Wound Recovery

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106544 - 106544

Published: April 1, 2025

Language: Английский

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In vitro and in silico pharmaco-nutritional assessments of some lesser-known Nigerian nuts: Persea americana, Tetracarpidium conophorum, and Terminalia catappa

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(4), P. e0319756 - e0319756

Published: April 9, 2025

Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, Terminalia cattapa kernels were evaluated in vitro silico. RBC membrane stabilisation for characteristics, antioxidant activities by ABTS, DPPH, H2O2, nitric oxide scavenging assays, α-glucosidase α-amylase inhibitory assays conducted used to evaluate anti-diabetic activity. With an IC50 value 208 μg/mL , P. showed maximum amount inhibition, according results, while T. catappa a somewhat lower degree inhibition at 236 . exhibited highest 312 µg/mL. strongest DPPH radical activity, ABTS effectiveness neutralising hydrogen peroxide. In tests using human red blood cells, hemolysis. While higher concentrations copper, manganese, potassium, calcium, magnesium concentrations. had considerably levels ash, proteins, lipids, carbohydrates than which quantity crude fibre, proximate analysis. Molecular docking experiments have revealed that plant extracts from americana, substantial binding affinities towards amylase. Pseudococaine, M-(1-methylbutyl) phenylmethylcarbamate, o-xylene, 1-deoxynojirimycin four compounds those acarbose. Acarbose nitrate not as compatible scores compared dimethyl phthalate, pseudococaine, M-(1-Methylbutyl)phenyl methylcarbamate, 2-chloro-3-oxohexanedioic acid, methyl 2-chloro-5-nitrobenzoate. These results suggest these hold great potential creation therapeutic medications specifically target oxidative stress-related diseases like diabetes.

Language: Английский

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