Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Фев. 10, 2023
EDITORIAL article Front. Physiol., 10 February 2023Sec. Renal Physiology and Pathophysiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1158436
Язык: Английский
Experimental Neurology, Год журнала: 2023, Номер 373, С. 114659 - 114659
Опубликована: Дек. 21, 2023
Язык: Английский
Процитировано
11
Cancer Drug Resistance, Год журнала: 2025, Номер 8(1)
Опубликована: Янв. 6, 2025
Ferroptosis is an iron-dependent form of programmed cell death induced by lipid peroxidation. This process regulated signaling pathways associated with redox balance, iron metabolism, and metabolism. Cancer cells' increased demand makes them especially susceptible to ferroptosis, significantly influencing cancer development, therapeutic response, metastasis. Recent findings indicate that cells can evade ferroptosis downregulating key related this process, contributing drug resistance. underscores the possibility modulating as approach counteract resistance enhance efficacy. review outlines involved in their interactions cancer-related pathways. We also highlight current understanding resistance, offering insights into how targeting provide novel approaches for drug-resistant cancers. Finally, we explore potential ferroptosis-inducing compounds examine challenges opportunities development evolving field.
Язык: Английский
Процитировано
0
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Фев. 27, 2025
Oxidative stress-prompted degeneration of the retinal pigment epithelium (RPE) notably contributes to onset age-related macular (AMD). However, pathways leading RPE deterioration and possible preventative strategies are not yet completely comprehended. Ferroptosis was assayed through evaluation lipid peroxidation (C11-BODIPY MDA), reactive oxygen species (ROS), transmission electron microscopy (TEM), iron content measurement, q-PCR, western blotting, immunofluorescence. To assess structure function in mice, ERG (electroretinography), OCT (optical coherence tomography), H&E (hematoxylin eosin) staining were employed. Network pharmacology methods utilized elucidate potential mechanisms underlying melatonin's protective effects against ferroptosis cells AMD. Genetic engineering techniques applied investigate regulatory relationships among phosphatidylinositol 3-kinase (PI3K), protein kinase-B (AKT), murine double minute-2 (MDM2), 53 (P53), solute carrier family 7 member 11 (SLC7A11). In vitro knockdown experiments MDM2 conducted explore its role within cells. Aβ1-40 can trigger Melatonin inhibit oxidative stress induced by exhibits a effect on Aβ1-40-induced AMD, significantly improving mouse retina layer, facilitating restoration visual function. revealed that targets melatonin AMD closely related ferroptosis, indicated predominant associated with PI3K/AKT/MDM2/P53 signaling pathway. Knocking down specific expression weaken inhibitory ferroptosis. suppress cell death via pathway, thereby preventing decelerating progression
Язык: Английский
Процитировано
0
Cell Death Discovery, Год журнала: 2024, Номер 10(1)
Опубликована: Окт. 9, 2024
The prevalence of urological malignancies remains a significant global health concern, particularly given the challenging prognosis for patients in advanced disease stages. Consequently, there is pressing need to explore molecular mechanisms that regulate development discover novel breakthroughs diagnosis and treatment. Ferroptosis, characterized by iron-ion-dependent lipid peroxidation, form programmed cell death (PCD) distinct from apoptosis, autophagy, necrosis. Notably, lipid, iron, glutathione metabolism intricately intracellular ferroptosis, playing essential roles progression various neoplasms drug resistance. In recent years, ferroptosis has been found be closely related malignancies. This paper provides an overview involvement pathogenesis malignancies, elucidates governing its regulation, synthesizes diagnosing treating these We aim provide new direction clinical treatment
Язык: Английский
Процитировано
2
Journal of Biochemical and Molecular Toxicology, Год журнала: 2023, Номер 38(1)
Опубликована: Окт. 31, 2023
Abstract Increasing evidence shows that microRNAs (miRNAs) contribute vital roles in papillary thyroid carcinoma (PTC) carcinogenesis, proliferation, invasion, and so on. As the most common endocrine malignancy, there still have largely unknown molecular events. First, our analysis open access database information indicates downregulation of let‐7a‐5p accelerates PTC progression. Next, lentivirus mediates overexpression cells, found suppressed cancer cells proliferation invasion. Interestingly, bioinformatics hints NR6A1 is potential target gene let‐7a‐5p. The regulation was validated by luciferase quantitative reverse transcription polymerase chain reaction (qRT‐PCR) tissue clinic tumors. Moreover, regulated involved lipogensis vitro vivo. Finally, abrogates PCT xenograft tumors growth, expression lipogenesis. Taken together, data suppresses progression through decreased lipogenesis, related let‐7a‐5p/NR6A1axis might be promising candidate targets for treatment.
Язык: Английский
Процитировано
3
Advances in protein chemistry and structural biology, Год журнала: 2024, Номер unknown, С. 191 - 269
Опубликована: Ноя. 16, 2024
Язык: Английский
Процитировано
0
Frontiers in Physiology, Год журнала: 2023, Номер 14
Опубликована: Фев. 10, 2023
EDITORIAL article Front. Physiol., 10 February 2023Sec. Renal Physiology and Pathophysiology Volume 14 - 2023 | https://doi.org/10.3389/fphys.2023.1158436
Язык: Английский
Процитировано
0