Chinese Journal of Cancer Research,
Год журнала:
2024,
Номер
36(6), С. 652 - 668
Опубликована: Янв. 1, 2024
Lipid
metabolic
reprogramming
is
considered
one
of
the
most
prominent
abnormalities
in
cancer,
and
fatty
acid
metabolism
a
key
aspect
lipid
metabolism.
Recent
studies
have
shown
that
its
related
pathways
play
important
roles
malignant
progression
nasopharyngeal
carcinoma
(NPC).
NPC
cells
adapt
to
harsh
environments
by
enhancing
biological
processes
such
as
metabolism,
uptake,
production,
oxidation,
thereby
accelerating
their
growth.
In
addition,
plays
central
role
tumor
microenvironment
(TME)
NPC,
phenotypic
transformation
immune
closely
Moreover,
contributes
escape,
which
significantly
affects
disease
treatment,
progression,
recurrence,
metastasis.
This
review
explores
recent
advances
focuses
on
interconnections
among
reprogramming,
immunity,
corresponding
therapies.
conclusion,
represents
potential
target
for
further
exploration
needed
develop
strategies
interaction
between
immunotherapy.
Trends in Pharmacological Sciences,
Год журнала:
2024,
Номер
45(6), С. 537 - 551
Опубликована: Май 17, 2024
Cancer
cells
perturb
lipid
metabolic
pathways
for
a
variety
of
pro-tumorigenic
functions,
and
deregulated
cellular
metabolism
is
hallmark
cancer
cells.
Although
alterations
in
have
been
appreciated
over
20
years,
there
are
no
FDA-approved
treatments
that
target
lipid-related
pathways.
Recent
advances
pertaining
to
cell
fatty
acid
synthesis
(FAS),
desaturation,
uptake,
microenvironmental
dietary
lipids,
tumor-infiltrating
immune
illuminated
promising
clinical
applications
targeting
metabolism.
This
review
highlights
emerging
targets
tumor
may
soon
impact
treatment.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 23, 2024
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
multifaceted
metabolic
disorder,
whose
global
prevalence
rapidly
increasing.
Acetyl
CoA
carboxylases
1
(ACACA)
the
key
enzyme
that
controls
rate
of
acid
synthesis.
Hence,
it
crucial
to
investigate
function
ACACA
in
regulating
lipid
metabolism
during
progress
NAFLD.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115741 - 115741
Опубликована: Окт. 19, 2023
Acetyl-coenzyme
A
(acetyl-CoA),
an
essential
metabolite,
not
only
takes
part
in
numerous
intracellular
metabolic
processes,
powers
the
tricarboxylic
acid
cycle,
serves
as
a
key
hub
for
biosynthesis
of
fatty
acids
and
isoprenoids,
but
also
signaling
substrate
acetylation
reactions
post-translational
modification
proteins,
which
is
crucial
epigenetic
inheritance
cells.
Acetyl-CoA
links
lipid
metabolism
with
histone
to
create
more
intricate
regulatory
system
that
affects
growth,
aggressiveness,
drug
resistance
malignancies
such
glioblastoma,
breast
cancer,
hepatocellular
carcinoma.
These
fascinating
advances
knowledge
acetyl-CoA
during
carcinogenesis
normal
physiology
have
raised
interest
regarding
its
modulation
malignancies.
In
this
review,
we
provide
overview
regulation
cancer
relevance
main
pathways
participates.
We
summarize
role
reprogramming
stress
cells,
well
medical
application
inhibitors
targeting
dysregulation
therapeutic
intervention
cancers.
Molecular Biomedicine,
Год журнала:
2024,
Номер
5(1)
Опубликована: Ноя. 29, 2024
Abstract
Tumor
energy
metabolism
plays
a
crucial
role
in
the
occurrence,
progression,
and
drug
resistance
of
tumors.
The
study
tumor
has
gradually
become
an
emerging
field
treatment.
Recent
studies
have
shown
that
epigenetic
regulation
is
closely
linked
to
metabolism,
influencing
metabolic
remodeling
biological
traits
cells.
This
review
focuses
on
primary
pathways
explores
therapeutic
strategies
target
these
pathways.
It
covers
key
areas
such
as
glycolysis,
Warburg
effect,
mitochondrial
function,
oxidative
phosphorylation,
adaptability
Additionally,
this
article
examines
regulator
SWI/SNF
complex
specifically
its
interactions
with
glucose,
lipids,
amino
acids.
Summarizing
aimed
at
pathways,
including
inhibitors
mitochondrial-targeted
drugs,
exploitation
vulnerabilities,
recent
developments
related
complexes
potential
targets.
clinical
significance,
challenges,
future
directions
research
are
discussed,
overcome
resistance,
combination
therapy,
application
new
technologies.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 14, 2025
Metabolic
reprogramming
is
one
of
the
major
biological
features
malignant
tumors,
playing
a
crucial
role
in
initiation
and
progression
cancer.
The
tumor
microenvironment
consists
various
non-cancer
cells,
such
as
hepatic
stellate
cancer-associated
fibroblasts
(CAFs),
immune
well
extracellular
matrix
soluble
substances.
In
liver
cancer,
metabolic
not
only
affects
its
own
growth
survival
but
also
interacts
with
other
cells
by
influencing
expression
release
metabolites
cytokines
(such
lactate,
PGE2,
arginine).
This
interaction
leads
to
acidification
restricts
uptake
nutrients
resulting
competition
symbiosis.
At
same
time,
neighboring
during
proliferation
differentiation
processes
impacts
immunity.
article
provides
comprehensive
overview
crosstalk
between
cancer
their
microenvironment,
deepening
our
understanding
relevant
findings
pathways.
contributes
further
regulation
development
evasion
mechanisms
while
providing
assistance
advancing
personalized
therapies
targeting
pathways
for
anti-cancer
treatment.
