Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Journal of Cancer Research and Clinical Oncology, Год журнала: 2024, Номер 150(4)

Опубликована: Апрель 25, 2024

Abstract Copper is a necessary micronutrient for maintaining the well-being of human body. The biological activity organic ligands, especially their anticancer activity, often enhanced when they coordinate with copper(I) and (II) ions. its compounds are capable inducing tumor cell death through various mechanisms action, including activation apoptosis signaling pathways by reactive oxygen species (ROS), inhibition angiogenesis, induction cuproptosis, paraptosis. Some copper complexes currently being evaluated in clinical trials ability to map hypoxia cancers, locally advanced rectal cancer bulky tumors. Several studies have shown that nanoparticles can be used as effective agents chemodynamic therapy, phototherapy, hyperthermia, immunotherapy. Despite promising copper-based compounds, use subject certain limitations. Elevated concentrations may promote growth, metastasis affecting cellular processes.

Язык: Английский

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Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells

Journal of Cellular Biochemistry, Год журнала: 2024, Номер 125(4)

Опубликована: Фев. 15, 2024

Abstract Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found Cannabis sativa , endowed with many pharmacological activities. We investigated cytotoxic effect CBD panel colorectal cancer (CRC) cells (HT‐29, SW480, HCT‐116, HCT‐15). induced significant cytotoxicity as evidenced results MTT assay, live‐dead flow cytometric analysis. Since displayed against CRC cells, we examined on decreased expression antiapoptotic proteins increased Annexin‐V‐positive well TUNEL‐positive suggesting that induces apoptosis. ATF4 (activating transcription factor 4) CHOP (CCAAT/enhancer‐binding homologous protein), elevated endoplasmic reticulum stress, enhanced reactive oxygen species levels indicating also promotes paraptosis. Atg7, phospho‐Beclin‐1, LC3 accelerates Since, MAPK pathway common cascade regulation autophagy, JNK, p38, ERK pathways. activated all forms inhibition these reverted observed effects. Our findings implied could induce cell death activating autophagy through pathway.

Язык: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Фев. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Язык: Английский

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Emerging role of immunogenic cell death in cancer immunotherapy

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 10, 2024

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to immunotherapy is suboptimal, primarily attributed low immunogenicity in certain types of malignant tumors. Immunogenic cell death (ICD) represents form regulated (RCD) capable enhancing tumor and activating tumor-specific innate adaptive responses immunocompetent hosts. Therefore, gaining deeper understanding ICD evolution crucial developing more therapeutic strategies. This review focuses exclusively on both historical recent discoveries related modes their mechanistic insights, particularly within context immunotherapy. Our findings are also highlighted, revealing mode induction facilitated by atypical interferon (IFN)-stimulated genes (ISGs), including polo-like kinase 2 ( PLK2 ), during hyperactive type I IFN signaling. The concludes discussing potential ICD, with special attention relevance preclinical settings field

Язык: Английский

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Targeting paraptosis in cancer: opportunities and challenges

Cancer Gene Therapy, Год журнала: 2024, Номер 31(3), С. 349 - 363

Опубликована: Янв. 4, 2024

Язык: Английский

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Nanomedicine-mediated regulated cell death in cancer immunotherapy

Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 174 - 194

Опубликована: Окт. 27, 2023

Язык: Английский

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Exploring beyond Common Cell Death Pathways in Oral Cancer: A Systematic Review

Biology, Год журнала: 2024, Номер 13(2), С. 103 - 103

Опубликована: Фев. 6, 2024

Oral squamous cell carcinoma (OSCC) is the most common and lethal type of head neck cancer in world. Variable response acquisition resistance to traditional therapies show that it essential develop novel strategies can provide better outcomes for patient. Understanding cellular molecular mechanisms death control has increased rapidly recent years. Activation pathways, such as emerging forms non-apoptotic programmed death, including ferroptosis, pyroptosis, necroptosis, NETosis, parthanatos, mitoptosis paraptosis, may represent clinically relevant therapeutic opportunities. This systematic review summarizes recently described OSCC, highlighting their potential informing diagnosis, prognosis treatment. Original studies explored any selected deaths OSCC were included. Electronic search, study selection, data collection risk bias assessment tools realized. The literature search was carried out four databases, extracted from 79 articles categorized grouped by death. Ferroptosis, necroptosis represented main studies, with links immunity inflammatory responses, progression OSCC. Harnessing these pathways be useful patient-specific individualized therapy. We perspectives on how different types integrated decision prognosis, treatment

Язык: Английский

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Necrosis Links Neurodegeneration and Neuroinflammation in Neurodegenerative Disease

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3636 - 3636

Опубликована: Март 24, 2024

The mechanisms of neuronal cell death in neurodegenerative disease remain incompletely understood, although recent studies have made significant advances. Apoptosis was previously considered to be the only mechanism diseases. However, findings challenged this dogma, identifying new subtypes necrotic death. present review provides an updated summary necrosis and discusses their potential roles Among numerous subtypes, including necroptosis, paraptosis, ferroptosis, pyroptosis, transcriptional repression-induced atypical (TRIAD) has been identified as a TRIAD is induced by functional deficiency TEAD-YAP self-amplifies via release HMGB1. feasible Alzheimer’s other In addition induction death, HMGB1 released during activates brain inflammatory responses, which link between neurodegeneration neuroinflammation.

Язык: Английский

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Rutin Linoleate Triggers Oxidative Stress-Mediated Cytoplasmic Vacuolation in Non-Small Cell Lung Cancer Cells

Life, Год журнала: 2024, Номер 14(2), С. 215 - 215

Опубликована: Фев. 1, 2024

Lung cancer (LC) represents one of the most prevalent health issues globally and is a leading cause tumor-related mortality. Despite being attractive compounds plant origin due to its numerous biological properties, therapeutic applications rutin (RUT) are limited by disadvantageous pharmacokinetics. Thus, present study aimed evaluate in vitro application two RUT fatty acids bioconjugates, oleate (RUT-O) linoleate (RUT-L), as potential improved RUT-based chemotherapeutics non-small cell lung (NSCLC) treatment. The results indicate that both lacked cytotoxic EpiAirway™ tissues at concentrations up 125 µM. However, only RUT-L exerted anti-tumorigenic activity NCI-H23 NSCLC cells after 24 h treatment reducing viability (up 47%), proliferation, neutral red uptake, causing membrane damage lactate dehydrogenase (LDH) leakage, affecting cytoskeletal distribution, inducing cytoplasmic vacuolation, increasing oxidative stress. cytopathic effects triggered 100 µM indicators non-apoptotic death pathway resembles characteristics paraptosis. novel findings this stand basis for further investigations on anti-cancer properties their underlying mechanisms.

Язык: Английский

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Kaempferide triggers apoptosis and paraptosis in pancreatic tumor cells by modulating the ROS production, SHP‐1 expression, and the STAT3 pathway

IUBMB Life, Год журнала: 2024, Номер 76(9), С. 745 - 759

Опубликована: Май 6, 2024

Abstract Pancreatic cancer is one of the deadliest diseases with a poor prognosis and five‐survival rate. The STAT3 pathway hyperactivated which contributes to sustained proliferative signals in pancreatic cells. We have isolated kaempferide (KF), an O ‐methylated flavonol, from green propolis Mimosa tenuiflora examined its effect on two forms cell death namely, apoptosis paraptosis. KF significantly increased cleavage caspase‐3 PARP. It also downmodulated expression Alix (an intracellular inhibitor paraptosis) CHOP ATF4 (transcription factors that promote indicating promotes as well reactive oxygen species (ROS) suggesting perturbance redox state. N‐acetylcysteine reverted apoptosis‐ paraptosis‐inducing effects KF. Some ROS inducers are known suppress investigation revealed downmodulates upstream kinases (JAK1, JAK2, Src). Additionally, elevated SHP‐1, tyrosine phosphatase involved negative modulation pathway. Knockdown SHP‐1 prevented KF‐driven inhibition. Altogether, has been identified promoter paraptosis cells through elevation generation expression.

Язык: Английский

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