Silibinin Suppresses Inflammatory Responses Induced by Exposure to Asian Sand Dust DOI Creative Commons
Se‐Jin Lee, So‐Won Pak, Woong‐Il Kim

и другие.

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1187 - 1187

Опубликована: Сен. 30, 2024

Asian sand dust (ASD), generated from the deserts of China and Mongolia, affects Korea Japan during spring autumn, causing harmful effects on various bio-organs, including respiratory system, due to its irritants such as fine dust, chemicals, toxic materials. Here, we investigated therapeutic silibinin against ASD-induced airway inflammation using mouse macrophage-like cell line RAW264.7 a murine model. ASD was intranasally administered mice three times week for 6 days by oral gavage. In ASD-stimulated cells, treatment decreased tumor necrosis factor-α production reduced expression p-p65NF-κB, p-p38, cyclooxygenase (COX)-2, while increasing heme oxygenase (HO)-1 expression. ASD-exposed mice, administration inflammatory count cytokines in bronchoalveolar lavage fluid infiltration lung tissue. Additionally, lowered oxidative stress, evidenced 8-hydroxy-2'-deoxyguanosin (8-OHdG) increased HO-1 The inflammatory-related proteins, COX-2, markedly administration. Overall, p-p38 response exposure, both vitro vivo. These findings suggest that mitigates pulmonary caused exposure reducing signaling indicating potential agent inflammation.

Язык: Английский

Silymarin and Inflammation: Food for Thoughts DOI Creative Commons
Peter F. Surai,

Anton Surai,

Katie Earle-Payne

и другие.

Antioxidants, Год журнала: 2024, Номер 13(1), С. 98 - 98

Опубликована: Янв. 14, 2024

Inflammation is a vital defense mechanism, creating hostile conditions for pathogens, preventing the spread of tissue infection and repairing damaged tissues in humans animals. However, when inflammation resolution delayed or compromised as result its misregulation, process proceeds from acute phase to chronic inflammation, leading development various illnesses. It proven that redox balance disturbances oxidative stress are among major factors inducing NF-κB over-inflammation. Therefore, anti-inflammatory properties natural antioxidants have been widely tested vitro vivo systems. Accumulating evidence indicates silymarin (SM) main constituent silibinin/silybin (SB) great potential an anti-inflammation agent. The mechanism SM/SB action attributed inhibition TLR4/NF-κB-mediated signaling pathways downregulated expression pro-inflammatory mediators, including TNF-α, IL-1β, IL-6, IL-12, IL-23, CCL4, CXCL10, etc. Of note, same model systems, was able upregulate cytokines (IL-4, IL-10, IL-13, TGF-β, etc.) lipid mediators involved inflammation. inflammatory were clearly demonstrated systems based on immune (macrophages monocytes) non-immune (epithelial, skin, bone, connective cancer) cells. At time, confirmed number models, toxicity nonalcoholic fatty liver disease, ischemia/reperfusion stress-induced injuries, ageing exercising wound healing many other relevant seems likely activities key elements health-promoting these phytochemicals.

Язык: Английский

Процитировано

16
Silibinin, a PLC-β3 inhibitor, inhibits mast cell activation and alleviates OVA-induced asthma DOI

Tzu‐Ting Chen,

Juan-Cheng Yang,

Guan-Yu Chen

и другие.

Molecular Immunology, Год журнала: 2025, Номер 178, С. 76 - 86

Опубликована: Янв. 26, 2025

Язык: Английский

Процитировано

0
Effects of Silibinin on Delaying Aging in Drosophila melanogaster DOI Creative Commons
Kai Zhu,

Hang Ni,

Eqra Hafeez

и другие.

Antioxidants, Год журнала: 2025, Номер 14(2), С. 147 - 147

Опубликована: Янв. 27, 2025

Aging is an inevitable physiological process, but delaying aging has always been enduring human pursuit. Silibinin (SIL), derived from the seeds of milk thistle plant, exhibits a broad spectrum pharmacological properties, including anti-tumor effects, liver protection, inhibition apoptosis, and alleviation inflammation. However, whether it anti-aging effects remains unclear. The SIL dietary supplement to Drosophila melanogaster prolonged lifespan, improved climbing ability, ameliorated age-associated intestinal barrier disruption, enhanced resistance oxidative stress, increased enzyme activities superoxide dismutase (SOD) catalase (CAT). Furthermore, RNA-seq results showed that addition significantly upregulated 74 genes downregulated 50 compared with control. KEGG (Kyoto Encyclopedia genomes) analysis demonstrated these differentially expressed were primarily involved in Toll signaling pathway endoplasmic reticulum proteins processing, six among which, IM2, IM3, Drsl3, CG7556, GCS1, TRAM, particularly regulation by supplementation. indicate enhancing antioxidant capacity regulating aging-related pathways. Therefore, shows potential application regimens.

Язык: Английский

Процитировано

0
Dapagliflozin ameliorates intestinal stem cell aging by regulating the MAPK signaling pathway in Drosophila DOI Creative Commons
Jinhua Yan,

Chenxi Feng,

H Zhang

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Апрель 23, 2025

Introduction Intestinal stem cells (ISCs) possess the ability to self-renew and differentiate, which is essential for maintaining intestinal tissue homeostasis. However, their functionality significantly declines with age, leading diminished regeneration an increased risk of age-associated diseases. Methods This study investigates effects Dapagliflozin (DAPA), a novel insulin sensitizer SGLT2 inhibitor, on aging ISCs using Drosophila melanogaster model. Our findings demonstrate that DAPA can inhibit MAPK signaling pathway, as confirmed by network pharmacology analysis molecular docking experiments. Results ameliorates ISC aging, improves function (including enhanced fecal excretion, restored barrier integrity acid-base balance), enhances healthspan. These results highlight potential anti-aging therapeutic agent. Discussion provides new evidence application treatment.

Язык: Английский

Процитировано

0
The Roles of Flavonoids in the Treatment of Inflammatory Bowel Disease and Extraintestinal manifestations : A Review DOI
Xu Gao,

Xi Feng,

Tao Hou

и другие.

Food Bioscience, Год журнала: 2024, Номер 62, С. 105431 - 105431

Опубликована: Ноя. 8, 2024

Язык: Английский

Процитировано

3
Inonotus obliquus aqueous extract inhibits intestinal inflammation and insulin metabolism defects in Drosophila DOI

Shichao Yu,

Zhixian Lai,

Hongmei Xue

и другие.

Toxicology Mechanisms and Methods, Год журнала: 2024, Номер unknown, С. 1 - 15

Опубликована: Июнь 14, 2024

In biomedical research, the fruit fly (

Язык: Английский

Процитировано

1
Drosophila: An Important Model for Exploring the Pathways of Inflammatory Bowel Disease (IBD) in the Intestinal Tract DOI Open Access

Chuisheng Zeng,

Fengying Liu,

Yuhan Huang

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(23), С. 12742 - 12742

Опубликована: Ноя. 27, 2024

Inflammatory bowel disease (IBD) is a chronic and recurring lifelong condition, the exact etiology of which remains obscure. However, an increasing corpus research underscores pivotal role cellular signaling pathways in both instigation management intestinal inflammation. Drosophila, owing to its prodigious offspring, abbreviated life cycle, conservation with mammals, among other advantages, has become model organism for IBD research. This review will expound on feasibility utilizing Drosophila as model, comparing architecture that inflammatory responses, pathways. Furthermore, it deliberate natural products across various biological models pathways, elucidating viability fruit flies modus operandi context IBD.

Язык: Английский

Процитировано

1
Vitamin B12 ameliorates gut epithelial injury via modulating the HIF-1 pathway and gut microbiota DOI Creative Commons

Chenxi Feng,

Jinhua Yan, Ting Luo

и другие.

Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)

Опубликована: Сен. 11, 2024

Язык: Английский

Процитировано

0
Silibinin Suppresses Inflammatory Responses Induced by Exposure to Asian Sand Dust DOI Creative Commons
Se‐Jin Lee, So‐Won Pak, Woong‐Il Kim

и другие.

Antioxidants, Год журнала: 2024, Номер 13(10), С. 1187 - 1187

Опубликована: Сен. 30, 2024

Asian sand dust (ASD), generated from the deserts of China and Mongolia, affects Korea Japan during spring autumn, causing harmful effects on various bio-organs, including respiratory system, due to its irritants such as fine dust, chemicals, toxic materials. Here, we investigated therapeutic silibinin against ASD-induced airway inflammation using mouse macrophage-like cell line RAW264.7 a murine model. ASD was intranasally administered mice three times week for 6 days by oral gavage. In ASD-stimulated cells, treatment decreased tumor necrosis factor-α production reduced expression p-p65NF-κB, p-p38, cyclooxygenase (COX)-2, while increasing heme oxygenase (HO)-1 expression. ASD-exposed mice, administration inflammatory count cytokines in bronchoalveolar lavage fluid infiltration lung tissue. Additionally, lowered oxidative stress, evidenced 8-hydroxy-2'-deoxyguanosin (8-OHdG) increased HO-1 The inflammatory-related proteins, COX-2, markedly administration. Overall, p-p38 response exposure, both vitro vivo. These findings suggest that mitigates pulmonary caused exposure reducing signaling indicating potential agent inflammation.

Язык: Английский

Процитировано

0