The Promising Effects of Erdosteine and Vitamin B in the Liver Ischemia/Reperfusion Model in Anesthetized Rats

Medicina, Год журнала: 2024, Номер 60(5), С. 783 - 783

Опубликована: Май 8, 2024

Background and Objectives: Erdosteine (Erd) is an antioxidant anti-inflammatory drug. Vitamin B has been reported to exert effects. In this study, we investigated the effect of erdosteine vitamin complex on a liver ischemia/reperfusion (I/R) model. Materials Methods: Thirty-two Wistar Albino male rats weighing 350–400 g were used. The animals randomly selected divided into four groups. groups are as follows: first group (Sham), second (I/R), third (I/R + vit B), fourth Erd). Rats subjected 45 min hepatic ischemia, followed by reperfusion period in I/R Erd An amount 150 mg/kg/day was given orally for 2 days, 0.05 mL/kg i.p. 30 before reperfusion. Serum biochemical parameters measured. Total Antioxidant Status (TAS) Oxidant (TOS) measured, Oxidative Stress Index (OSI) calculated. Hepatic tissue samples taken evaluation histopathological features. Results: terms all parameters, there significant differences compared with (p < 0.01). aspartate aminotransferase (AST), alanine (ALT), lactate dehydrogenase (LDH), TNF-alpha, IL-6 levels, between treatment lowest TOS OSI levels obtained groups, these had statistically significantly higher TAS sham Conclusions: As preliminary experimental our study suggests that agents may have potential diagnostic therapeutic implications both ischemic conditions liver-related diseases. These results suggest combination be used protect against devastating effects injury. Our needs confirmed clinical studies large participation.

Язык: Английский

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The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats

Molecular Biology Reports, Год журнала: 2025, Номер 52(1)

Опубликована: Янв. 30, 2025

Язык: Английский

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Anti‐Inflammatory Treatment of Subarachnoid Hemorrhage by Self‐Assembled Silymarin Nanoparticles

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Subarachnoid hemorrhage (SAH) is a common hemorrhagic cerebrovascular disease with high disability rate and mortality. Early brain injury (EBI) the main cause of mortality delayed neurological dysfunction in patients SAH. Neuroinflammation important pathological processes EBI.We prepared Silymarin nanoparticles (SIM NPs) through solvent precipitation method investigated their role combating EBI following SAH mice. We found that SIM NPs diameter 150 nm have strongest ability to cross blood‐brain barrier. are spherical contain irregular particles inside, which may be composed mainly silibinin assembled hydrogen bonding. Further vivo experiments showed improved short‐term mice, reduced cortical neural damage, inflammation Nrf2/STING pathway. Finally, water maze can improve long‐term memory learning Based on above results, we conclude silymarin reduce after by inhibiting pathway, neuroinflammation M1 polarization microglia.

Язык: Английский

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Evidence construction of Silibinin capsules against alcoholic liver disease based on a meta-analysis and systematic review

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Фев. 4, 2025

Background In recent years, the incidence of alcoholic liver disease (ALD) has rapidly increased worldwide, becoming a significant health issue. Silibinin capsules have shown potential in treating ALD, but clinical evidence is still insufficient. This meta-analysis aimed to evaluate efficacy and safety treatment ALD. Methods The study was registered with PROSPERO (CRD42024509676). Randomized controlled trials (RCTs) were included from six databases, covering period database inception 30 December 2023. Primary outcomes function indicators such as alanine aminotransferase (ALT), aspartate (AST), gamma-glutamyl transferase (GGT), total bilirubin (TBIL), lipid including triglycerides (TG) cholesterol (TC), coagulation prothrombin time (PT), fibrosis indicator (PC-III), Effective Rate. Analysis performed using Review Manager 5.4.1 STATA 14.0. Results 15 RCTs involving 1,221 patients, compared non-Silibinin group, showed terms function, levels, effective rate patients Detailed parameters follows: ALT [SMD = −1.16, 95% CI (−1.84, −0.47)], AST −1.56, (−2.18, −0.95)], GGT −1.48, (−2.09, −0.87)], TBIL −1.14, (−2.16, −0.13)], TG −1.29, (−1.93, −0.66)], TC −1.11, (−1.61, −0.61)], PT −0.01, (−0.29, 0.26)], PC-III −1.94, (−3.04, −0.84)], Rate [OR 3.60, (2.28, 5.70)]. Importantly, exhibited favorable profile, only mild gastrointestinal reactions reports insomnia adverse events. Conclusion review reveals confirms that drug an adjuvant therapy alleviate At present, mechanism action this for ALD unclear, we expect more experimental studies prove value capsules. Systematic Registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=509676 .

Язык: Английский

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Immunomodulatory properties of endophytic fungi: Implications for therapeutics

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 147 - 156

Опубликована: Янв. 1, 2025

Язык: Английский

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Combining nutraceuticals and a mediterranean diet for managing metabolic dysfunction associated with steatotic liver disease

World Journal of Hepatology, Год журнала: 2025, Номер 17(4)

Опубликована: Апрель 25, 2025

This study was performed by Cano Contreras et al , who explored the effects of alpha-lipoic acid (ALA) and Silybum marianum (SM) supplementation combined with a mediterranean diet (MD) on metabolic dysfunction-associated steatotic liver disease (MASLD). The randomized controlled design use transient elastography provide methodological strengths, whereas focus Mexican cohort addresses critical gap in regional MASLD research. Although improvements visceral fat attenuation parameters (CAP) were observed, key markers, including transaminases lipid profiles, showed no significant changes, raising concerns about intervention's comprehensive impact. reliance CAP absence mechanistic biomarker analysis limit insights into antioxidant anti-inflammatory pathways ALA SM. Future research should explore synergistic other nutraceuticals, such as vitamin E polyphenols, include extended follow-up patient stratification to assess long-term benefits personalized therapeutic outcomes. Addressing these limitations could solidify role nutraceuticals management enable development more effective sustainable interventions.

Язык: Английский

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Impact of silymarin‐supplemented cookies on liver enzyme and inflammatory markers in non‐alcoholic fatty liver disease patients

Food Science & Nutrition, Год журнала: 2024, Номер 12(10), С. 7273 - 7286

Опубликована: Июль 17, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is a growing public health concern characterized by fat accumulation and severe disorders like nonalcoholic steatohepatitis (NASH), which are influenced obesity, inflammatory processes, metabolic pathways. This research investigates the potential of silymarin‐supplemented cookies in managing NAFLD evaluating their impact on enzyme activity, markers, lipid profiles. A clinical trial Lahore, Pakistan, involved 64 patients. Participants were divided into placebo three treatment groups, with latter receiving for 3 months. The study assessed levels at baseline after intervention, utilizing statistical analyses to evaluate differences. profile renal function test (RFT) also measured months each group safety assessment. After months, groups indicated more significant decreases enzymes compared ( p ≤ .05). Treatment showed reductions alanine aminotransferase (ALT) (64.39–49.38 U/L) aspartate (AST) (61.53–45.38 U/L). improvements alkaline phosphatase (ALP) AST/ALT ratio. Additionally, demonstrated reduction markers. decrease C‐reactive protein (CRP) (6.32–3.39 mg/L) erythrocyte sedimentation rate (ESR) (38.72–23.86 mm/h), indicating that individuals may benefit from intervention's benefits lowering inflammation. revealed an intervention significantly improved enzymes, profiles participants, suggesting health.

Язык: Английский

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Unveiling the Potential of Silymarin, Spirulina platensis, and Chlorella vulgaris towards Cardiotoxicity via Modulating Antioxidant Activity, Inflammation, and Apoptosis in Rats

Life, Год журнала: 2024, Номер 14(10), С. 1289 - 1289

Опубликована: Окт. 11, 2024

This study assessed the possible pharmacological effects of

Язык: Английский

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Effects of Six Natural Compounds and Their Derivatives on the Control of Coccidiosis in Chickens

Microorganisms, Год журнала: 2024, Номер 12(3), С. 601 - 601

Опубликована: Март 17, 2024

Chicken coccidiosis costs the poultry industry over GBP 10 billion per year. The main method of preventing and controlling in chickens continues to be use drugs. Unfortunately, prevalence drug resistance field reduces or even eliminates effectiveness drugs, residues food supply chain can also harmful humans. Therefore, safe effective anticoccidial drugs are urgently needed. Natural products have many advantages such as being safe, inexpensive a sustainable way control coccidiosis. In this study, effects six natural compounds were tested by Eimeria tenella infection. Oocyst production, cecum lesion, body weight gain, feed conversion ratio, intestinal microbiota measured. results showed that nerolidol had moderate effect on maintaining both gain ratio. Silymarin dihydroartemisinin significant reducing total oocyst output. Dihydroartemisinin significantly reduced lesion caused infection, but compound may toxic host at informed doses because it decreases growth survival rates. addition, silymarin partly restored after challenge. This indicates silymarin, dihydroartemisinin, chicken Our data provide basic knowledge about compounds/derivates.

Язык: Английский

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A Descriptive Review of the Antioxidant Effects and Mechanisms of Action of Berberine and Silymarin

Molecules, Год журнала: 2024, Номер 29(19), С. 4576 - 4576

Опубликована: Сен. 26, 2024

Oxidative stress is a key factor in the development of chronic diseases such as type 2 diabetes, cardiovascular diseases, and liver disorders. Antioxidant therapies that target oxidative damage show significant promise preventing treating these conditions. Berberine, an alkaloid derived from various plants Berberidaceae family, enhances cellular defenses against through several mechanisms. It activates AMP-activated protein kinase (AMPK) pathway, which reduces mitochondrial reactive oxygen species (ROS) production improves energy metabolism. Furthermore, it boosts activity antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), thus protecting cells damage. These actions make berberine effective managing conditions, neurodegenerative Silymarin, flavonolignan complex Silybum marianum, particularly for protection. nuclear erythroid 2-related (Nrf2) enhancing enzyme expression stabilizing membranes. Additionally, silymarin formation ROS by chelating metal ions, also diminishes inflammation. This makes beneficial conditions non-alcoholic fatty disease (NAFLD) alcohol-related review aims to highlight distinct mechanisms exert their effects.

Язык: Английский

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