Essential oils as antibacterials against multidrug-resistant foodborne pathogens: Mechanisms, recent advances, and legal considerations

Food Bioscience, Год журнала: 2025, Номер 64, С. 105937 - 105937

Опубликована: Янв. 18, 2025

Язык: Английский

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Eco-friendly synthesis of Chitosan NPs from Fioria vitifolia (L.) L: Potential to Antibacterial, Antioxidant, Cytotoxicity properties of HepG2 cells and their evaluation of safety on Zebrafish embryo

Results in Engineering, Год журнала: 2025, Номер unknown, С. 104076 - 104076

Опубликована: Янв. 1, 2025

Язык: Английский

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Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare

Опубликована: Фев. 27, 2024

The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to production is crucial. This review focuses on seaweed as a sustainable resource for greening processes. Seaweed offers advantages such renewability, abundance, and positive footprint. begins by providing an overview practices the challenges faced achieving sustainability. It then discusses resource, including cultivation techniques benefits. has various applications manufacturing, extracting purifying bioactive compounds with potential therapeutic properties. Seaweed’s role developing green technologies, seaweed-based excipients, biodegradable packaging materials, source energy processes, highlighted. economic implications incorporating solutions are discussed, emphasizing reduced carbon footprint cost-effectiveness. Regulatory industrial perspectives addressed, examining challenges, opportunities implementing manufacturing. Collaboration between academia, industry, regulatory bodies crucial successful integration. presents future directions opportunities, emerging trends innovations areas further research, policy development, industry engagement recommendations. Incorporating into facilitates reduction impact, promotes efficiency, contributes showcases means foster greener addressing concerns, promoting

Язык: Английский

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Recent advances in metal-free catalytic enantioselective higher-order cycloadditions

Organic Chemistry Frontiers, Год журнала: 2024, Номер 11(6), С. 1824 - 1842

Опубликована: Янв. 1, 2024

In this review, we briefly summarize the recent research progress in enantioselective higher-order cycloadditions, focusing on preparation of medium-sized and multicyclic chiral molecules by metal-free catalysis.

Язык: Английский

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Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(1), С. 30 - 30

Опубликована: Янв. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Язык: Английский

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Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review

Plants, Год журнала: 2025, Номер 14(2), С. 206 - 206

Опубликована: Янв. 13, 2025

Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield

Язык: Английский

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Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders

Biomedicines, Год журнала: 2025, Номер 13(2), С. 454 - 454

Опубликована: Фев. 12, 2025

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms

Язык: Английский

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Traditional medicine regulation status and challenges in Malawi and Nigeria

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 14, 2025

The World Health Organization encourages governments to develop legal frameworks for the regulation of traditional medicines ensure safety, quality, and efficacy. There is inadequate published research on medicine legislative tools Good manufacturing practices compliance by manufacturers in many countries Sub-Saharan Africa. study assessed regulatory status challenges Malawi Nigeria. A descriptive cross-sectional was done using a structured questionnaire checklist requirements collect data from officers, facilities, herbal medicinal products. Twenty-three officers Medicines Regulatory Authorities Ministries Nigeria were interviewed. Thirty-one small-scale manufacturers, sixty-six products Malawi, twenty-eight Nigeria, that used people living with HIV AIDS, evaluated. Pharmacy Authority scored 7.7% while National Agency Food Drug Administration Control 77.0% 13-item requirements. Ministry Health, 28.6% 71.4% 7-item Both have no regulations practice, has not been integrated into healthcare system. Most Malawian showed poor compliance, deficiencies observed personnel hygiene (58.6%), cleaning production equipment (69.0%), storage rooms (72.4%), documentation standard operating procedures premises (93.1%). Labelling non-compliance respectively, list active ingredient names (45.5% vs. 93.0%, p < 0.001), quantities ingredients (12.1% 53.6%, side effects (9.1% 57.1%, conditions (15.2% 67.9%, 0.001). lacks strong framework medicines, current Manufacturing Practices standards labelling, posing serious public health risks. Urgent action needed establish comprehensive regulations, including guidelines registering AIDS. While more developed framework, enforcement remains challenge. Strengthening inspections ensuring adherence safety quality critical safeguarding building consumer confidence both countries' industries.

Язык: Английский

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Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 6937 - 6937

Опубликована: Июнь 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Язык: Английский

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The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 30, 2024

Introduction In recent years, diverse initiatives have been carried out to control the COVID-19 pandemic, ranging from measures restricting social activities analyzing drugs and vaccines. Studies on herbal medicines are also increasingly conducted in various countries as an adjuvant therapy or supplement. Therefore, this systematic review aimed investigate efficacy of analyzed through clinical trials with randomized controlled trial method. The outcomes Length Stay (LOS), Negative Conversion Time (NCT), Rate (NCR) were main focus. Methods An extensive literature spanning 2019 2023 was using well-known databases including PubMed, Scopus, Cochrane. search included relevant keywords such “randomized trial,” “COVID-19,” “herbal medicine.” Results A total 8 articles part inclusion criteria LOS, NCT, NCR. terms LOS outcomes, all types showed significant results, Persian Medicine Herbal (PM Herbal), Barley Water (PBW), Jingyin Granules (JY granules), Reduning Injection, Phyllanthus emblica (Amla). However, only JY granules results NCR outcome, while Injection reducing NCT. Conclusion These findings enrich our understanding potential benefits influencing NCT parameters patients. worked treat antiviral, anti-inflammatory, immunomodulatory mechanisms.

Язык: Английский

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