Unveiling Anticancer Phytoconstituents: A Comprehensive Review of GC–MS Applications in Natural Products DOI Open Access

Apoorva Verma,

Manish Vyas, Sanjeev Kumar Sahu

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(9)

Published: March 1, 2025

Abstract Cancer remains a significant global health challenge characterized by the uncontrolled proliferation of malignant cells. While conventional treatments such as chemotherapy and radiotherapy are effective, they often cause severe side effects, driving interest in alternative therapies derived from medicinal plants. These plants rich bioactive compounds, including terpenoids, phenolics, flavonoids, which exhibit promising anticancer properties. This review focuses on gas chromatography–mass spectrometry (GC–MS) for identifying characterizing these phytochemicals, highlighting its value natural product research due to precise separation identification capabilities. An analysis over 30 studies identified key compounds with cytotoxic effects. Limonene (IC 50 : 47–57.34 µg/mL A549, HepG2, CaCo, PANC‐1 cells), squalene 26.22 JURKAT), sesamin 52–57.2 MCF‐7 HCT116 β ‐caryophyllene 19.4–58.2 ME‐180 cells) have exhibited potent activities. Despite advantages, GC‐MS realizes limitations, difficulty differentiating structural isomers detecting low‐abundance compounds. Integrating GC–MS complementary analytical techniques can overcome challenges enhance phytochemical profiling. Addressing bioavailability conducting clinical trials is essential translating findings into effective cancer therapies. underscore therapeutic potential phytochemicals safer alternatives treatments.

Language: Английский

Essential oils as antibacterials against multidrug-resistant foodborne pathogens: Mechanisms, recent advances, and legal considerations DOI
Mabrouk Sobhy, Esraa A. Abdelkarim, Mohamed A. Hussein

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: 64, P. 105937 - 105937

Published: Jan. 18, 2025

Language: Английский

Citations

4
Eco-friendly synthesis of Chitosan NPs from Fioria vitifolia (L.) L: Potential to Antibacterial, Antioxidant, Cytotoxicity properties of HepG2 cells and their evaluation of safety on Zebrafish embryo DOI Creative Commons

Mohamed Imath,

Chinnasamy Ragavendran, Chinnaperumal Kamaraj

et al.

Results in Engineering, Journal Year: 2025, Volume and Issue: unknown, P. 104076 - 104076

Published: Jan. 1, 2025

Language: Английский

Citations

3
Seaweed: a sustainable solution for greening drug manufacturing in the pursuit of sustainable healthcare DOI Creative Commons
Leonel Pereira, João Cotas

Published: Feb. 27, 2024

The environmental impact of drug manufacturing raises concerns about sustainability in healthcare. To address this, exploring alternative approaches to production is crucial. This review focuses on seaweed as a sustainable resource for greening processes. Seaweed offers advantages such renewability, abundance, and positive footprint. begins by providing an overview practices the challenges faced achieving sustainability. It then discusses resource, including cultivation techniques benefits. has various applications manufacturing, extracting purifying bioactive compounds with potential therapeutic properties. Seaweed’s role developing green technologies, seaweed-based excipients, biodegradable packaging materials, source energy processes, highlighted. economic implications incorporating solutions are discussed, emphasizing reduced carbon footprint cost-effectiveness. Regulatory industrial perspectives addressed, examining challenges, opportunities implementing manufacturing. Collaboration between academia, industry, regulatory bodies crucial successful integration. presents future directions opportunities, emerging trends innovations areas further research, policy development, industry engagement recommendations. Incorporating into facilitates reduction impact, promotes efficiency, contributes showcases means foster greener addressing concerns, promoting

Language: Английский

Citations

12
Recent advances in metal-free catalytic enantioselective higher-order cycloadditions DOI Creative Commons
Bei Zhang, Jian Wang

Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(6), P. 1824 - 1842

Published: Jan. 1, 2024

In this review, we briefly summarize the recent research progress in enantioselective higher-order cycloadditions, focusing on preparation of medium-sized and multicyclic chiral molecules by metal-free catalysis.

Language: Английский

Citations

8
Phytochemicals in Breast Cancer Prevention and Treatment: A Comprehensive Review DOI Creative Commons
Adil Farooq Wali, Jayachithra Ramakrishna Pillai, Sirajunisa Talath

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 30 - 30

Published: Jan. 6, 2025

Extensive investigation has been conducted on plant-based resources for their pharmacological usefulness, including various cancer types. The scope of this review is wider than several studies with a particular focus breast cancer, which an international health concern while studying sources flavonoids, carotenoids, polyphenols, saponins, phenolic compounds, terpenoids, and glycosides apart from focusing nursing. Important findings prior are synthesized to explore these compounds' sources, mechanisms action, complementary synergistic effects, associated side effects. It was reviewed that the exposure certain doses catechins, piperlongumine, lycopene, isoflavones cucurbitacinfor sufficient period can provide profound anticancer benefits through biological events such as cell cycle arrest, cells undergoing apoptosis disruption signaling pathways including, but not limited JAK-STAT3, HER2-integrin, MAPK. Besides, study also covers potential adverse effects phytochemicals. Regarding mechanisms, widest attention paid Complementary strategies discussed indicate it would be realistic alter dosage delivery systems liposomes, nanoparticles, nanoemulsions, films enhance efficacy. Future research directions include refining approaches, further elucidating molecular conducting clinical trials validate findings. These efforts could significantly advance role phytocompounds in management.

Language: Английский

Citations

1
Extraction and Processing of Bioactive Phytoconstituents from Widely Used South African Medicinal Plants for the Preparation of Effective Traditional Herbal Medicine Products: A Narrative Review DOI Creative Commons

Sphamandla Hlatshwayo,

Nokukhanya Thembane,

Suresh Babu Naidu Krishna

et al.

Plants, Journal Year: 2025, Volume and Issue: 14(2), P. 206 - 206

Published: Jan. 13, 2025

Medicinal plants are sources of crude traditional herbal medicines that utilized to reduce the risk of, treat, or manage diseases in most indigenous communities. This is due their potent antioxidant and anti-inflammatory effects. It estimated about 80% population developing countries rely on for healthcare. signifies need medicines, which polyherbal formulations prepared by health practitioners. review examines preparatory steps extract bioactive phytoconstituents post-extraction processes increase potency extracted phytoconstituents. Achieving this will allow reduced use plant materials promote sustainable limited resource medicinal plants, especially our South African context. Electronic ethnobotanical books online databases were used find studies focus phytoconstituent extraction processing enhance Modification synthesize daughter compounds facilitates an enhancement bioavailability. Based data collected through review, importance understanding properties targeted essential selecting required method. determines quality yield

Language: Английский

Citations

1
Therapeutic Potential of Medicinal Plants and Their Phytoconstituents in Diabetes, Cancer, Infections, Cardiovascular Diseases, Inflammation and Gastrointestinal Disorders DOI Creative Commons
Prawej Ansari,

Alexa D. Reberio,

Nasim Ahmad Ansari

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 454 - 454

Published: Feb. 12, 2025

Conditions like diabetes mellitus (DM), cancer, infections, inflammation, cardiovascular diseases (CVDs), and gastrointestinal (GI) disorders continue to have a major global impact on mortality morbidity. Medicinal plants been used since ancient times in ethnomedicine (e.g., Ayurveda, Unani, Traditional Chinese Medicine, European Medicine) for the treatment of wide range disorders. Plants are rich source diverse phytoconstituents with antidiabetic, anticancer, antimicrobial, antihypertensive, antioxidant, antihyperlipidemic, cardioprotective, immunomodulatory, and/or anti-inflammatory activities. This review focuses 35 most commonly reported these disorders, particular emphasis their traditional uses, phytoconstituent contents, pharmacological properties, modes action. Active phytomolecules therapeutic potential include cucurbitane triterpenoids, diosgenin, limonoids (azadiradione gedunin), which exhibit antidiabetic triterpenoids specifically activating Glucose Transporter Type 4 (GLUT4) translocation. Capsaicin curcumin demonstrate anticancer activity by deactivating NF-κB arresting cell cycle G2 phase. Antimicrobial activities observed piperine, reserpine, berberine, dictamnine, chelerythrine, allitridin, latter two triggering bacterial lysis. Quercetin, catechin, genistein suppressing CD8+ cytotoxic T function. Ginsenoside Rg1 ginsenoside Rg3 treating diseases, PPARα promoter, PI3K/Akt pathway. In contrast, ternatin, tannins, quercitrin regulating arachidonic acid metabolism cyclooxygenase (COX) lipoxygenase activity. Further studies warranted fully investigate clinical benefits phytoconstituents, as well elucidate underlying molecular mechanisms

Language: Английский

Citations

1
Traditional medicine regulation status and challenges in Malawi and Nigeria DOI Creative Commons
John Mponda, Adamson S. Muula, Augustine Choko

et al.

BMC Complementary Medicine and Therapies, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 14, 2025

The World Health Organization encourages governments to develop legal frameworks for the regulation of traditional medicines ensure safety, quality, and efficacy. There is inadequate published research on medicine legislative tools Good manufacturing practices compliance by manufacturers in many countries Sub-Saharan Africa. study assessed regulatory status challenges Malawi Nigeria. A descriptive cross-sectional was done using a structured questionnaire checklist requirements collect data from officers, facilities, herbal medicinal products. Twenty-three officers Medicines Regulatory Authorities Ministries Nigeria were interviewed. Thirty-one small-scale manufacturers, sixty-six products Malawi, twenty-eight Nigeria, that used people living with HIV AIDS, evaluated. Pharmacy Authority scored 7.7% while National Agency Food Drug Administration Control 77.0% 13-item requirements. Ministry Health, 28.6% 71.4% 7-item Both have no regulations practice, has not been integrated into healthcare system. Most Malawian showed poor compliance, deficiencies observed personnel hygiene (58.6%), cleaning production equipment (69.0%), storage rooms (72.4%), documentation standard operating procedures premises (93.1%). Labelling non-compliance respectively, list active ingredient names (45.5% vs. 93.0%, p < 0.001), quantities ingredients (12.1% 53.6%, side effects (9.1% 57.1%, conditions (15.2% 67.9%, 0.001). lacks strong framework medicines, current Manufacturing Practices standards labelling, posing serious public health risks. Urgent action needed establish comprehensive regulations, including guidelines registering AIDS. While more developed framework, enforcement remains challenge. Strengthening inspections ensuring adherence safety quality critical safeguarding building consumer confidence both countries' industries.

Language: Английский

Citations

1
Natural Guardians: Natural Compounds as Radioprotectors in Cancer Therapy DOI Open Access
Anna Stasiłowicz-Krzemień, Anna Gościniak, Dorota Formanowicz

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6937 - 6937

Published: June 25, 2024

Cancer remains a significant global health challenge, with millions of deaths attributed to it annually. Radiotherapy, cornerstone in cancer treatment, aims destroy cells while minimizing harm healthy tissues. However, the harmful effects irradiation on normal present formidable obstacle. To mitigate these effects, researchers have explored using radioprotectors and mitigators, including natural compounds derived from secondary plant metabolites. This review outlines diverse classes compounds, elucidating their roles as protectants cells. Furthermore, highlights potential radioprotective agents capable enhancing body's resilience radiation therapy. By integrating into treatment regimens, clinicians may improve therapeutic outcomes adverse Ongoing research this area holds promise for developing complementary strategies optimize radiotherapy efficacy enhance patient quality life.

Language: Английский

Citations

7
The efficacy of herbal medicines on the length of stay and negative conversion time/rate outcomes in patients with COVID-19: a systematic review DOI Creative Commons
Irma Rahayu Latarissa, Anna Meiliana,

Ida Paulina Sormin

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 30, 2024

Introduction In recent years, diverse initiatives have been carried out to control the COVID-19 pandemic, ranging from measures restricting social activities analyzing drugs and vaccines. Studies on herbal medicines are also increasingly conducted in various countries as an adjuvant therapy or supplement. Therefore, this systematic review aimed investigate efficacy of analyzed through clinical trials with randomized controlled trial method. The outcomes Length Stay (LOS), Negative Conversion Time (NCT), Rate (NCR) were main focus. Methods An extensive literature spanning 2019 2023 was using well-known databases including PubMed, Scopus, Cochrane. search included relevant keywords such “randomized trial,” “COVID-19,” “herbal medicine.” Results A total 8 articles part inclusion criteria LOS, NCT, NCR. terms LOS outcomes, all types showed significant results, Persian Medicine Herbal (PM Herbal), Barley Water (PBW), Jingyin Granules (JY granules), Reduning Injection, Phyllanthus emblica (Amla). However, only JY granules results NCR outcome, while Injection reducing NCT. Conclusion These findings enrich our understanding potential benefits influencing NCT parameters patients. worked treat antiviral, anti-inflammatory, immunomodulatory mechanisms.

Language: Английский

Citations

5