Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 13, 2024
Язык: Английский
Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100744 - 100744
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2025, Номер 183, С. 117818 - 117818
Опубликована: Янв. 17, 2025
Язык: Английский
Процитировано
0
Brain Injury, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Апрель 21, 2025
TBI's intricate pathophysiology, which includes oxidative stress, neuroinflammation, apoptosis, and mechanical injury, makes it a serious public health concern. Although stabilization secondary damage management are the main goals of current treatments, their efficacy is still restricted. The potential for improving patient outcomes by combining phytochemicals with traditional medicines examined in this review. study neuroprotective qualities ginsenosides, ginkgolides, resveratrol, curcumin as well antioxidant anti-inflammatory activities. Analysis was done on molecular pathways medication delivery techniques to improve translational drug availability clinical practice. Phytochemical substances directly influence TBI-related neurogenic functional restoration while also affecting subsequent neural processes. Particle-based medicine platforms enhance therapeutic efficacy, emerging innovative solutions targeted delivery. When medical therapies integrate phytochemicals, becomes possible achieve better results through enhanced synergy. This review uniquely integrates standard TBI emphasizing advanced strategies neuroprotection outcomes. Unlike previous studies, explores novel platforms, such nanoparticle-based systems, highlights synergy between conventional recovery.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(13), С. e32755 - e32755
Опубликована: Июнь 8, 2024
The involvement of neuroinflammation in the pathogenesis neurodegenerative disorders (NDs) is very significant. Currently, only symptomatic treatments exist, and there are no drugs that modify progression Alzheimer's disease (AD) or other NDs. Consequently, increasing attention on addressing AD-related using anti-inflammatory compounds antioxidants. a growing exploration dietary phytochemicals as potential therapeutic agents for treating inflammation. Citral, monoterpene, under investigation due to its neuroprotective effects. dysregulation iron homeostasis crucial factor supporting neuroinflammation, underscoring significance proper balance. Human transferrin (htf) major homeostasis. In this study, we examined binding dynamics htf–citral complex through diverse experimental methods. Molecular docking studies revealed citral binds residues htf, forming stable complex. UV-visible spectroscopy demonstrated with htf good affinity, evident from constant 1.48 X105 M-1. Further, fluorescence entrenched htf-citral formation; demonstrates an excellent affinity 106 Moreover, assay at various temperatures deciphered be driven by both static dynamic quenching. analysis enthalpy change (ΔH) entropy (ΔS) formation was mainly hydrophobic interactions..The current work gives platform develop innovative strategies targeting citral, particularly
Язык: Английский
Процитировано
3
Ageing Research Reviews, Год журнала: 2024, Номер 100, С. 102469 - 102469
Опубликована: Авг. 25, 2024
Язык: Английский
Процитировано
3
Pharmacological Research - Natural Products, Год журнала: 2025, Номер unknown, С. 100249 - 100249
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 13, 2024
Язык: Английский
Процитировано
2