Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine DOI
Soumik Das, V. Devi Rajeswari, Ganesh Venkatraman

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Language: Английский

Co-delivery of curcumin-resveratrol-carnosic acid complex promotes neurogenesis and cognitive recovery in a rodent model of repeated mild traumatic brain injury DOI Open Access
Mohind C. Mohan,

A S Anjana,

T A Hilmi Jaufer

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117818 - 117818

Published: Jan. 17, 2025

Language: Английский

Citations

1
Medicinal Plants with Neuroprotective Potential in East African Countries: A Systematic Review DOI Creative Commons

Ibe Michael Usman,

Ekom Monday Etukudo, Elna Owembabazi

et al.

Phytomedicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100744 - 100744

Published: Jan. 1, 2025

Language: Английский

Citations

1
Computational and spectroscopic insight into the binding of citral with human transferrin: Targeting neurodegenerative diseases DOI Creative Commons
Anas Shamsi, Moyad Shahwan, Mohammad Furkan

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e32755 - e32755

Published: June 8, 2024

The involvement of neuroinflammation in the pathogenesis neurodegenerative disorders (NDs) is very significant. Currently, only symptomatic treatments exist, and there are no drugs that modify progression Alzheimer's disease (AD) or other NDs. Consequently, increasing attention on addressing AD-related using anti-inflammatory compounds antioxidants. a growing exploration dietary phytochemicals as potential therapeutic agents for treating inflammation. Citral, monoterpene, under investigation due to its neuroprotective effects. dysregulation iron homeostasis crucial factor supporting neuroinflammation, underscoring significance proper balance. Human transferrin (htf) major homeostasis. In this study, we examined binding dynamics htf–citral complex through diverse experimental methods. Molecular docking studies revealed citral binds residues htf, forming stable complex. UV-visible spectroscopy demonstrated with htf good affinity, evident from constant 1.48 X105 M-1. Further, fluorescence entrenched htf-citral formation; demonstrates an excellent affinity 106 Moreover, assay at various temperatures deciphered be driven by both static dynamic quenching. analysis enthalpy change (ΔH) entropy (ΔS) formation was mainly hydrophobic interactions..The current work gives platform develop innovative strategies targeting citral, particularly

Language: Английский

Citations

5
Potential of integrating phytochemicals with standard treatments for enhanced outcomes in TBI DOI

VP Lakshmi Priya,

M. Devi

Brain Injury, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: April 21, 2025

TBI's intricate pathophysiology, which includes oxidative stress, neuroinflammation, apoptosis, and mechanical injury, makes it a serious public health concern. Although stabilization secondary damage management are the main goals of current treatments, their efficacy is still restricted. The potential for improving patient outcomes by combining phytochemicals with traditional medicines examined in this review. study neuroprotective qualities ginsenosides, ginkgolides, resveratrol, curcumin as well antioxidant anti-inflammatory activities. Analysis was done on molecular pathways medication delivery techniques to improve translational drug availability clinical practice. Phytochemical substances directly influence TBI-related neurogenic functional restoration while also affecting subsequent neural processes. Particle-based medicine platforms enhance therapeutic efficacy, emerging innovative solutions targeted delivery. When medical therapies integrate phytochemicals, becomes possible achieve better results through enhanced synergy. This review uniquely integrates standard TBI emphasizing advanced strategies neuroprotection outcomes. Unlike previous studies, explores novel platforms, such nanoparticle-based systems, highlights synergy between conventional recovery.

Language: Английский

Citations

0
Nano-formulation of Phytochemicals to Combat Neurodegenerative Diseases: Current and Thorough Strategies DOI
Sailee Chowdhury, Garima Kumari,

Tanmay Jit

et al.

Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: 7, P. 100249 - 100249

Published: May 5, 2025

Language: Английский

Citations

0
Stroke Studies in Large Animals: Prospects of Mitochondrial Transplantation and Enhancing Efficiency using Hydrogels and Nanoparticle-assisted Delivery DOI
Öner Ülger, Ismail Eş, Christopher M. Proctor

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102469 - 102469

Published: Aug. 25, 2024

Language: Английский

Citations

3
Phytochemicals in Parkinson’s Disease: a Pathway to Neuroprotection and Personalized Medicine DOI
Soumik Das, V. Devi Rajeswari, Ganesh Venkatraman

et al.

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 13, 2024

Language: Английский

Citations

2