European Journal of Medicinal Chemistry, Год журнала: 2024, Номер 282, С. 117042 - 117042
Опубликована: Ноя. 12, 2024
Язык: Английский
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 7, 2025
The intestinal epithelium, beyond its role in absorption and digestion, serves as a critical protective mechanical barrier that delineates the luminal contents gut microbiota from lamina propria within resident mucosal immune cells to maintain homeostasis. is manifested contiguous monolayer of specialized epithelial (IEC), interconnected through tight junctions (TJs). integrity this paramount. Consequently, excessive IEC death advances permeability consequence thereof translocation bacteria into propria, subsequently triggering an inflammatory response, which underpins clinical disease trajectory bowel (IBD). A burgeoning body evidence illustrates landscape where undergoes several model programmed cell (PCD) pathophysiology pathogenesis IBD. Apoptosis, necroptosis, pyroptosis represent principal modalities PCD with intricate specific pathways molecules. Ample has revealed substantial mechanistic convergence crosstalk among these three aforementioned forms death, expanding conceptualization PANoptosis orchestrated by PNAoptosome complex. This review provides concise overview molecular mechanisms apoptosis, pyroptosis. Furthermore, based on between deaths IEC, details current knowledge regarding regulation natural products. Our objective broaden comprehension innovative underlying IBD furnish foundation for developing more drugs treatment IBD, benefiting both practitioners research workers.
Язык: Английский
Процитировано
3
Journal of Functional Foods, Год журнала: 2025, Номер 125, С. 106690 - 106690
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
2
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Июнь 4, 2024
Ulcerative colitis (UC), a subtype of inflammatory bowel disease, manifests with symptoms such as abdominal pain, diarrhea, and mucopurulent, bloody stools. The pathogenesis UC is not fully understood. At present, the incidence has increased significantly around world. Conventional therapeutic arsenals are relatively limited, often poor efficacy many adverse effects. In contrast, traditional Chinese medicine (TCM) holds promise due to their notable effectiveness, reduced recurrence rates, minimal side recent years, significant progress been made in basic research on TCM for treatment. It found that inhibition ferroptosis through intervention can promote intestinal mucosal healing reverse UC. mechanism action involves multiple targets pathways. Aim review This summarizes experimental studies targeted regulation by its impact aiming provide theoretical basis prevention, treatment, further drug development Results Ferroptosis disrupts antioxidant mechanisms epithelial cells, damages mucosa, participates pathological process acts various pathways Nrf2 / HO-1 GSH/GPX4, blocking progression inhibiting damage thereby alleviating Conclusion diverse array single herbs, extracts herbal formulas facilitates selective innovative new methods targeting Although studying compound formulas, extracts, there still issues clinical designs, necessitating in-depth scientific exploration research.
Язык: Английский
Процитировано
4
Molecular Medicine, Год журнала: 2024, Номер 30(1)
Опубликована: Дек. 20, 2024
Abstract Diabetic kidney disease (DKD), one of the most prevalent microvascular complications diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in deterioration renal cells such as podocytes tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis, represents a spectrum demise processes intricately governed genetic mechanisms vivo. Under physiological conditions, PCD facilitates turnover cellular populations serves protective mechanism to eliminate impaired or cells, thereby preserving tissue homeostasis amidst hyperglycemic stress. However, existing research predominantly elucidates individual modes death, neglecting intricate interplay mutual modulation observed among various forms PCD. In this comprehensive review, we delineate diverse regulatory governing elucidate crosstalk dynamics distinct pathways. Furthermore, review recent advancements understanding pathogenesis explore their implications DKD. Additionally, potential natural products derived primarily botanical sources therapeutic agents, highlighting multifaceted effects on modulating crosstalk, proposing novel strategies for DKD treatment.
Язык: Английский
Процитировано
3
Frontiers in Pharmacology, Год журнала: 2025, Номер 16
Опубликована: Апрель 9, 2025
Ulcerative colitis (UC), a chronic inflammatory bowel disease, is driven by dysregulated immune responses and persistent intestinal inflammation. Pyroptosis, caspase/gasdermin-mediated cell death that exacerbates mucosal damage through excessive cytokine release epithelial barrier disruption. Although pyroptosis considered to be key mechanism in the pathogenesis of UC, systematic assessment role natural products targeting pathway remains critical research gap. The purpose this review investigate regulatory effects on UC elucidate mechanisms action potential therapeutic effects. Key findings highlight polyphenols (e.g., resveratrol), flavonoids Quercetin), terpenoids as promising agents inhibit NLRP3 inflammasome activation, suppress gasdermin D cleavage, restore integrity, thereby reducing pro-inflammatory preclinical models. Current evidence shows enhanced efficacy safety when these compounds are combined with standard therapies, but clinical translation requires overcoming three barriers: limited human trial data, uncharacterized polypharmacology, suboptimal pharmacokinetics needing formulation refinement. Future should prioritize standardized animal-to-human translational models, mechanistic studies synergistic pathways, rigorous validation harness full pyroptosis-targeted therapies.
Язык: Английский
Процитировано
0
Journal of Bioenergetics and Biomembranes, Год журнала: 2025, Номер unknown
Опубликована: Апрель 21, 2025
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2025, Номер 157, С. 114704 - 114704
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0
Food Science & Nutrition, Год журнала: 2025, Номер 13(5)
Опубликована: Май 1, 2025
ABSTRACT Diabetic wound healing critically depends on functional endothelial cells for angiogenesis, yet the hyperglycemic microenvironment induces dysfunction through oxidative stress, inflammation, and senescence. Although ferroptosis has been recognized as a critical pathological factor contributing to impaired diabetic healing, therapeutic potential of resveratrol (Res), natural polyphenol with well‐documented antioxidant anti‐ferroptotic properties, remains underexplored in this context. This study aimed investigate protective effects Res elucidate its underlying mechanisms healing. In vitro experiments systematically evaluated Res's impact cellular inflammatory responses, senescence levels, angiogenic capacity. Subsequent vivo studies assessed by monitoring progression analyzing associated histological changes. To clarify promotion we conducted comprehensive analyses measuring intracellular reactive oxygen species, lipid peroxidation mitochondrial membrane morphology, ferroptosis‐related marker expression, upstream signaling pathway regulation. significantly reduced HG‐induced responses human umbilical vein while enhancing their vitro. results showed that not only markedly accelerated but also demonstrated multiple beneficial effects, including effective suppression senescence, decreased promoted angiogenesis. Mechanistic investigations confirmed achieves these inhibiting activation PI3K‐AKT‐Nrf2 axis. Our demonstrate protects from activating signaling, thereby promoting angiogenesis These findings highlight promising candidate repair justify further clinical investigation.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Авг. 6, 2024
Modified Gegen Qinlian Decoction (MGQD) has been shown to effectively relieve ulcerative colitis (UC) without a known pharmacological mechanism. In this study, the anti-colitis efficaciousness of MGQD and its underlying mechanisms in UC were evaluated.
Язык: Английский
Процитировано
2
Toxicology Reports, Год журнала: 2024, Номер 14, С. 101858 - 101858
Опубликована: Дек. 16, 2024
Язык: Английский
Процитировано
2