Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
87(1), С. 209 - 216
Опубликована: Дек. 11, 2024
Global
plastic
production
surged
to
400.3
million
metric
tons
in
2022,
contributing
significantly
environmental
pollution.
Projections
estimate
that
13.2
billion
of
waste
will
be
present
ecosystems
by
2050.
This
increase
has
led
substantial
human
exposure
microplastics
(MPs)
and
nanoplastics
(NPs).
While
their
general
health
impacts
are
well-documented,
the
specific
effects
on
cardiovascular
remain
underexplored.
review
aims
examine
presence
MPs
NPs
environment,
routes
exposure,
toxicological
implications
for
system
(CVS),
focusing
oxidative
stress,
apoptosis,
cardiac
fibrosis,
major
adverse
events
(MACE).
A
comprehensive
literature
was
conducted
using
PubMed,
Scopus,
Google
Scholar.
Relevant
studies
from
past
10
years
were
selected
based
keywords
like
"microplastics,"
"nanoplastics,"
"cardiovascular
health."
found
air,
water,
food,
entering
body
primarily
through
inhalation,
ingestion,
dermal
contact.
These
particles
induce
mitochondrial
dysfunction,
which
impair
health.
have
been
detected
arterial
tissues,
particularly
atherosclerotic
plaques,
correlating
with
increased
MACE
risk.
MP
is
linked
VC,
reduced
vessel
flexibility,
thrombosis
severity.
Additionally,
contribute
inflammation
lipid
metabolism
disruption,
further
exacerbate
heart
disease.
The
evidence
suggests
a
concerning
link
between
health,
highlighting
urgent
need
research
understand
long-term
CVSs.
Environment International,
Год журнала:
2025,
Номер
unknown, С. 109421 - 109421
Опубликована: Март 1, 2025
The
environmental
fragmentation
of
plastics
generates
a
mixture
plastic
particles
various
sizes,
which
frequently
co-occur
with
other
mobile
and
persistent
pollutants.
Despite
the
prevalence
such
scenarios,
interaction
between
micro-
nanoplastics
(MNPs)
their
combined
effects
pollutants,
as
highly
toxic
hexavalent
chromium
(Cr(VI)),
remain
almost
entirely
unexplored
in
mammalian
species.
This
study
demonstrated
that
nanoplastic
microplastic
co-aggregate
together
influence
Cr
bioaccumulation
patterns
related
physiological
alterations
rats.
Following
four-week
repeated
intragastric
exposure
Wistar
rats
to
MNPs
Cr(VI),
either
alone
or
combination,
significantly
enhanced
liver,
heart,
brain,
skin.
Under
co-exposure
conditions,
Cr(VI)
was
primary
driver
cellular
observed
blood,
including
shifts
immune
cell
subpopulations
(e.g.,
neutrophils,
lymphocytes)
red
blood
indices,
while
serum
biochemistry
reflected
limited
stress.
per
se
decreased
creatine
kinase
activity
increased
cholesterol
levels.
In
summary,
polystyrene
increase
distribution
bioavailability,
but
does
not
uniformly
exacerbate
toxicity.
Instead,
may
selectively
alter
responses,
emphasizing
need
for
deeper
understanding
potential
health
risks.
Annals of Medicine and Surgery,
Год журнала:
2024,
Номер
87(1), С. 209 - 216
Опубликована: Дек. 11, 2024
Global
plastic
production
surged
to
400.3
million
metric
tons
in
2022,
contributing
significantly
environmental
pollution.
Projections
estimate
that
13.2
billion
of
waste
will
be
present
ecosystems
by
2050.
This
increase
has
led
substantial
human
exposure
microplastics
(MPs)
and
nanoplastics
(NPs).
While
their
general
health
impacts
are
well-documented,
the
specific
effects
on
cardiovascular
remain
underexplored.
review
aims
examine
presence
MPs
NPs
environment,
routes
exposure,
toxicological
implications
for
system
(CVS),
focusing
oxidative
stress,
apoptosis,
cardiac
fibrosis,
major
adverse
events
(MACE).
A
comprehensive
literature
was
conducted
using
PubMed,
Scopus,
Google
Scholar.
Relevant
studies
from
past
10
years
were
selected
based
keywords
like
"microplastics,"
"nanoplastics,"
"cardiovascular
health."
found
air,
water,
food,
entering
body
primarily
through
inhalation,
ingestion,
dermal
contact.
These
particles
induce
mitochondrial
dysfunction,
which
impair
health.
have
been
detected
arterial
tissues,
particularly
atherosclerotic
plaques,
correlating
with
increased
MACE
risk.
MP
is
linked
VC,
reduced
vessel
flexibility,
thrombosis
severity.
Additionally,
contribute
inflammation
lipid
metabolism
disruption,
further
exacerbate
heart
disease.
The
evidence
suggests
a
concerning
link
between
health,
highlighting
urgent
need
research
understand
long-term
CVSs.
