Microplastics and nanoplastics: emerging threats to cardiovascular health – a comprehensive review DOI Open Access
Hamza Irfan,

Haider Irfan,

M. A. Khan

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 87(1), P. 209 - 216

Published: Dec. 11, 2024

Global plastic production surged to 400.3 million metric tons in 2022, contributing significantly environmental pollution. Projections estimate that 13.2 billion of waste will be present ecosystems by 2050. This increase has led substantial human exposure microplastics (MPs) and nanoplastics (NPs). While their general health impacts are well-documented, the specific effects on cardiovascular remain underexplored. review aims examine presence MPs NPs environment, routes exposure, toxicological implications for system (CVS), focusing oxidative stress, apoptosis, cardiac fibrosis, major adverse events (MACE). A comprehensive literature was conducted using PubMed, Scopus, Google Scholar. Relevant studies from past 10 years were selected based keywords like "microplastics," "nanoplastics," "cardiovascular health." found air, water, food, entering body primarily through inhalation, ingestion, dermal contact. These particles induce mitochondrial dysfunction, which impair health. have been detected arterial tissues, particularly atherosclerotic plaques, correlating with increased MACE risk. MP is linked VC, reduced vessel flexibility, thrombosis severity. Additionally, contribute inflammation lipid metabolism disruption, further exacerbate heart disease. The evidence suggests a concerning link between health, highlighting urgent need research understand long-term CVSs.

Language: Английский

Characterization of microplastics in human follicular fluid and assessment of their potential impact on mouse oocyte maturation in vitro DOI Creative Commons

Danyu Ni,

Kai Yu, Nan Yan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117796 - 117796

Published: Feb. 1, 2025

Microplastics (MPs) have been identified in various human tissues and organs. This study aims to evaluate the presence of MPs follicular fluid (hFF) their potential impact on oocyte maturation. Laser direct infrared spectroscopy 19 hFF samples 7956 particles, including 1739 microplastics (21.9 %) from 30 types. Of these, 923 particles had matching degrees > 0.8, 7033 between 0.65 0.8. The most abundant were Chlorinated Polyethylene (CPE), Fluorosilicone rubber, Polyvinyl chloride (PVC), Butadiene rubber (BR), Styrene-butadiene-styrene (SBS), with diameters ranging 20 100 μm. Five random analyzed by pyrolysis-gas chromatography-mass spectrometry, which detected four types microplastics-Polyethylene (PE), Polypropylene (PP), Polystyrene (PS), PVC-at varying concentrations. PE was (22.284 mg/kg), followed PVC (1.061 PP (0.837 PS (0.600 mg/kg). Based diameter concentration ranges hFF, we used seven fluorescence-labeled MP beads-PE, PVC, PP, PS, CPE, Polymethylmethacrylate (PMMA), Polytetrafluoroethylene (PTFE)-to assess mouse vitro results showed that smaller beads (e.g., 50 μm PE) more likely penetrate zona pellucida enter oocyte, while larger 500 nm PMMA) tended adhere remain outside oocyte. All hindered maturation, resulting reductions maturation rates compared control group. Our findings suggest contaminate may impair

Language: Английский

Citations

0
Association of PM2.5-bound multiple metals co-exposure with early cardiovascular damage: A panel study in young adults combing metabolomics DOI
Junjie Chen,

Qingfeng Zhou,

Yingrong Wang

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 371, P. 125964 - 125964

Published: March 2, 2025

Language: Английский

Citations

0
Oral Exposure to Nylon-11 and Polystyrene Nanoplastics During Early-Life in Rats DOI Creative Commons
Ninell P. Mortensen,

Maria Moreno Caffaro,

Sai Archana Krovi

et al.

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(6), P. 465 - 465

Published: March 19, 2025

A critical knowledge gap currently exists regarding the potential risks of exposure to nanoplastics (NPs), particularly early in life during key stages growth and development. Globally abundant plastics, polyamide (nylon) polystyrene (PS), exist various products have been detected food beverages as small-scale plastics. In this study, we evaluated how early-life NPs affects biological metrics rat pups. Male female animals received an oral dose (20 mg/kg/day) nylon-11 (114 ± 2 nm) or PS (85 1 between postnatal day (PND) 7 10. The results showed slight differences ratio liver weight body for male pups exposed NPs. Cardiac performance levels neurotransmitters related metabolites brain tissue no controls. endogenous metabolite profile plasma was altered by administration NPs, suggesting perturbation metabolic pathways involved amino acid lipid metabolism. This study explored impacts NP life, supporting need continued investigations into health effects from

Language: Английский

Citations

0
PVC Nanoplastics Impair Cardiac Function via Lysosomal and Mitochondrial Dysfunction DOI
Guoxia Liu,

Qimei Bao,

Chunkai Zhang

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 151736 - 151736

Published: April 1, 2025

Language: Английский

Citations

0
Propionic acid/FBP1 is involved in polystyrene nanoplastic-induced cardiac injury via the gut-heart axis DOI Creative Commons

Huiwen Kang,

Danyang Huang, Wei Zhang

et al.

Particle and Fibre Toxicology, Journal Year: 2025, Volume and Issue: 22(1)

Published: May 9, 2025

Language: Английский

Citations

0
Microplastics and nanoplastics: emerging threats to cardiovascular health – a comprehensive review DOI Open Access
Hamza Irfan,

Haider Irfan,

M. A. Khan

et al.

Annals of Medicine and Surgery, Journal Year: 2024, Volume and Issue: 87(1), P. 209 - 216

Published: Dec. 11, 2024

Global plastic production surged to 400.3 million metric tons in 2022, contributing significantly environmental pollution. Projections estimate that 13.2 billion of waste will be present ecosystems by 2050. This increase has led substantial human exposure microplastics (MPs) and nanoplastics (NPs). While their general health impacts are well-documented, the specific effects on cardiovascular remain underexplored. review aims examine presence MPs NPs environment, routes exposure, toxicological implications for system (CVS), focusing oxidative stress, apoptosis, cardiac fibrosis, major adverse events (MACE). A comprehensive literature was conducted using PubMed, Scopus, Google Scholar. Relevant studies from past 10 years were selected based keywords like "microplastics," "nanoplastics," "cardiovascular health." found air, water, food, entering body primarily through inhalation, ingestion, dermal contact. These particles induce mitochondrial dysfunction, which impair health. have been detected arterial tissues, particularly atherosclerotic plaques, correlating with increased MACE risk. MP is linked VC, reduced vessel flexibility, thrombosis severity. Additionally, contribute inflammation lipid metabolism disruption, further exacerbate heart disease. The evidence suggests a concerning link between health, highlighting urgent need research understand long-term CVSs.

Language: Английский

Citations

1