Targeting Metabolic Diseases with Celastrol: A Comprehensive Review of Anti-Inflammatory Mechanisms and Therapeutic Potential
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119560 - 119560
Опубликована: Фев. 1, 2025
Язык: Английский
The Therapeutic Effect and Mechanism of Traditional Chinese Medicine in Type 2 Diabetes Mellitus and Its Complications
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2025,
Номер
Volume 18, С. 1599 - 1627
Опубликована: Май 1, 2025
Traditional
Chinese
Medicine
(TCM)
has
recently
emerged
as
a
beacon
for
the
treatment
of
diabetes
and
its
complications.
Many
TCMs
that
are
commonly
used,
have
potentially
demonstrated
significant
anti-diabetic
effects.
The
mechanisms
these
effects
been
extensively
discussed
using
modern
techniques,
such
genomics,
mass
spectrometry,
network
pharmacology.
Studies
TCM
can
influence
glucose
metabolism
pancreatic
function
via
diverse
array
including
PI3K/AKT
AMPK
pathways.
not
only
exhibits
potential
in
but
also
reduces
risk
diabetic
It
is
effective
nephropathy
(DN),
retinopathy
(DR),
neuropathy
(DPN),
cardiomyopathy,
peripheral
angiopathy.
Research
prescriptions,
herbal
medicines,
their
extracts
play
role
variety
molecular
antioxidation,
apoptosis
regulation,
hypoxia
improvement,
autophagy,
promotion
lipid
metabolism.
antioxidant
properties
received
considerable
attention.
Recent
studies
they
capable
effectively
eliminating
free
radicals
from
body
reducing
damage
to
cells
caused
by
oxidative
stress.
Consequently,
crucial
associated
This
review
summarizes
ever-expanding
scope
applicability
field
diabetes,
providing
support
innovative
ideas
healthcare.
could
help
seek
more
pharmacological
targets
basic
study
well
serve
complement
strategy
prevention
benefiting
patients.
More
large
series
RCT
clinical
investigations
will
eventually
examine
efficacy
specific
formulas
on
therapeutic
effect
DM
complication
where
currently
treatments
be
satisfied.
Язык: Английский
Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA
Food Science & Nutrition,
Год журнала:
2025,
Номер
13(6)
Опубликована: Май 23, 2025
ABSTRACT
Diabetic
nephropathy,
a
serious
diabetes
complication,
lacks
effective
treatments.
Traditional
Chinese
medicine
Zuogui
Pill
(ZGP)
and
Yougui
(YGP)
have
definite
clinical
adjunctive
effect
on
diabetic
nephropathy.
Given
their
similar
compositions,
studying
shared
mechanisms
could
provide
novel
perspectives
into
discovering
therapeutic
targets
for
Extraction
of
ZGP
(EZP)
YGP
(EYP)
was
prepared
by
in
vitro
digestion.
EZP
EYP
inhibited
the
gene
expression
FN1
MMP9
renal
fibrosis
cell
model.
A
transcriptional
regulatory
network
revealed
mechanisms,
with
HIF1A
as
key
transcription
factor.
In
an
insulin
resistance
model,
led
to
decrease
glucose
consumption.
suggested
that
different
panels,
but
PPARA
common
CA9
PDK1
,
downstream
genes
HIF1A,
PDK4
PPARA,
were
activated
both
EYP,
which
showed
potential
new
total
42
compounds
from
screened
mediators
HIF1AN
EGLN1,
interacted
proteins
HIF1A.
8
compounds,
including
verbascoside,
agonists
based
molecular
docking.
Verbascoside
improved
The
study
clarified
mechanism
regulating
provided
ideas
discovery
treatment
nephropathy
development
natural
nutrients.
Язык: Английский
Dilemmas in Elderly Diabetes and Clinical Practice Involving Traditional Chinese Medicine
Pharmaceuticals,
Год журнала:
2024,
Номер
17(7), С. 953 - 953
Опубликована: Июль 16, 2024
Diabetes
is
a
widespread
chronic
disease
that
occurs
mainly
in
the
elderly
population.
Due
to
difference
pathophysiology
between
and
young
patients,
current
clinical
practice
treat
patients
with
anti-diabetes
medications
still
faces
some
challenges
dilemmas,
such
as
urgent
need
for
early
diagnosis
prevention,
an
imbalance
restricted
dietary
intake
risk
of
undernutrition.
Traditional
Chinese
medicine
(TCM)
offers
various
treatment
regimens
are
actively
utilized
field
diabetes
management.
Through
multiple
targets
pathways,
TCM
formulas,
medicinal
herbs,
active
natural
products
enhance
efficacy
prevention
control
measures,
simplify
complex
medication
management,
improve
common
symptoms
diabetic
complications
people.
Historically,
have
played
key
role
material
composition
analysis
mechanism
interpretation
enable
drug
discovery.
However,
there
been
few
conclusions
on
this
topic.
This
review
summarizes
development
management
people,
existing
evidence-based
practices,
prospects
future
development.
Язык: Английский
Differential mechanisms of Liuwei Dihuang pill-derived formulas in treating diabetic nephropathy based on in vitro experiments and transcriptomic analysis
Food Bioscience,
Год журнала:
2024,
Номер
unknown, С. 105732 - 105732
Опубликована: Дек. 1, 2024
Язык: Английский
Biological evaluation of nutritional traditional fruit Mangifera camptosperma against diabetes and hyperlipidemia
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2024,
Номер
11, С. 100436 - 100436
Опубликована: Май 10, 2024
The
objective
of
the
study
was
to
determine
antidiabetic
and
antihyperlipidemic
effects
Mangifera
camptosperma
leaves
extract
using
streptozotocin-induced
animal
model.
M.
extracted
with
hydroethanolic
(50:50)
solvent
soxhlet
apparatus.
Traditional
Chinese
medicine
(TCM)
is
often
given
as
an
adjuvant
alleviate
diabetic
symptoms.
plant
extracts
were
used
presence
phytochemicals
present
in
them
different
tests.
Diabetes
induced
on
animals
streptozotocin
(STZ)
65
mg/kg
through
intra-peritoneal
route.
Oral
administration
at
doses
200
400
assess
its
effects.
phytochemical
analysis
showing
carbohydrates,
alkaloids,
tannins,
glycosides,
flavonoids.
control
group
had
blood
glucose
levels
102
126
mg/kg,
respectively,
after
receiving
test
medication,
but
rats
treated
showed
a
substantial
decrease
90.11
±
5.71
(200
mg/kg)
82.12
3.99
(400
mg/kg).
If
compared
group,
for
21
days
resulted
(p<0.05)
serum
total
cholesterol
(106.12
5.94
mg/dL)
triglyceride
(83.11
4.04
mg/dL),
well
increase
HDL
(36.15
3.04
mg/dL).
This
found
that
while
administered
rats,
lowered
improved
lipid
profiles.
It
can
be
concluded
from
may
useful
treating
hyperlipidemic
type-2
diabetes
alternative
medicine.
Язык: Английский