Microorganisms,
Год журнала:
2024,
Номер
12(11), С. 2207 - 2207
Опубликована: Окт. 31, 2024
The
escalating
global
threat
of
antibiotic
resistance
necessitates
innovative
strategies,
such
as
the
combination
antibiotics
with
adjuvants.
Monotherapy
rifampicin
is
more
likely
to
induce
in
pathogens
compared
other
antibiotics.
Herein,
we
found
that
antihypertensive
drug
guanethidine
enhanced
activity
against
certain
clinically
resistant
Gram-negative
bacteria,
resulting
a
reduction
up
128-fold
minimum
inhibitory
concentration.
In
infected
animal
models,
this
has
achieved
treatment
benefits,
including
increased
survival
and
decreased
bacterial
burden.
antimicrobial
mechanism
synergy
involves
disruption
outer
membrane
leading
dissipation
proton
motive
force.
This
results
an
increase
reactive
oxygen
species
ATP
synthesis,
severely
disturbing
energy
metabolism
ultimately
increasing
mortality.
summary,
potential
become
novel
adjuvant
for
rifampicin,
offering
new
option
clinical
infections.
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 197 - 197
Опубликована: Янв. 17, 2025
Chronic
endometritis
(CE)
is
a
persistent
inflammatory
condition
of
the
endometrium
characterized
by
abnormal
infiltration
plasma
cells
into
endometrial
stroma.
Frequently
associated
with
repeated
implantation
failure,
recurrent
pregnancy
loss,
and
infertility,
CE
significantly
impacts
women's
health,
contributing
to
conditions
such
as
uterine
bleeding
endometriosis.
Treatment
typically
involves
antibiotic
therapy;
however,
efficacy
these
treatments
increasingly
compromised
rise
antimicrobial
resistance
(AMR).
This
paper
examines
critical
links
between
AMR
CE,
proposing
strategies
enhance
clinical
management
optimize
treatment
outcomes.
Microorganisms,
Год журнала:
2025,
Номер
13(3), С. 557 - 557
Опубликована: Март 1, 2025
Antimicrobial
resistance
(AMR)
is
a
growing
global
health
crisis
that
threatens
the
efficacy
of
antibiotics
and
modern
medical
interventions.
The
emergence
multidrug-resistant
(MDR)
pathogens,
exacerbated
by
misuse
in
healthcare
agriculture,
underscores
urgent
need
for
innovative
solutions.
(1)
Background:
AMR
arises
from
complex
interactions
between
human,
animal,
environmental
health,
further
aggravated
overuse
inadequate
regulation
antibiotics.
Conventional
treatments
are
increasingly
ineffective,
necessitating
alternative
strategies.
Emerging
approaches,
including
bacteriophage
therapy,
antimicrobial
peptides
(AMPs),
nanotechnology,
microbial
extracellular
vesicles
(EVs),
CRISPR-based
antimicrobials,
provide
novel
mechanisms
complement
traditional
combating
resistant
pathogens.
(2)
Methods:
This
review
critically
analyzes
advanced
antibacterial
strategies
conjunction
with
systemic
reforms
such
as
stewardship
programs,
One
Health
framework,
surveillance
tools.
These
methods
can
enhance
detection,
guide
interventions,
promote
sustainable
practices.
Additionally,
economic,
logistical,
regulatory
challenges
impeding
their
implementation
evaluated.
(3)
Results:
technologies,
CRISPR
exhibit
promising
potential
targeting
mechanisms.
However,
disparities
resource
distribution
barriers
hinder
widespread
adoption.
Public–private
partnerships
agriculture
practices
critical
to
overcoming
these
obstacles.
(4)
Conclusions:
A
holistic
integrated
approach
essential
mitigating
impact
AMR.
By
aligning
therapeutic
policies,
fostering
interdisciplinary
collaboration,
ensuring
equitable
distribution,
we
develop
response
this
21st-century
challenge.
Advanced Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Abstract
Traditional
biomaterial
development
lacks
systematicity
and
predictability,
posing
significant
challenges
in
addressing
the
intricate
engineering
issues
related
to
infections
with
drug‐resistant
bacteria.
The
unprecedented
ability
of
artificial
intelligence
(AI)
manage
complex
systems
offers
a
novel
paradigm
for
materials
development.
However,
no
AI
model
currently
guides
antibacterial
biomaterials
based
on
an
in‐depth
understanding
interplay
between
In
this
study,
AI‐guided
design
platform
(AMP‐hydrogel‐Designer)
is
developed
generate
biomaterials.
This
utilizes
generative
multi‐objective
constrained
optimization
thiol‐containing
high‐efficiency
antimicrobial
peptide
(AMP),
that
functionally
coupled
hydrogel
form
network
structure.
Additionally,
Cu‐modified
barium
titanate
(Cu‐BTO)
incorporated
facilitate
further
cross–linking
via
Cu
2+
/SH
coordination
produce
AI‐AMP‐hydrogel.
vitro,
AI‐AMP‐hydrogel
exhibits
>
99.99%
bactericidal
efficacy
against
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
Escherichia
coli
(
E.
coli)
.
Furthermore,
Cu‐BTO
converts
mechanical
stimulation
into
electrical
signals,
thereby
promoting
expression
growth
factors
angiogenesis.
rat
dynamic
wounds,
AI‐AMP
significantly
reduces
MRSA
load
markedly
accelerates
wound
healing.
Therefore,
strategy
innovative
solution
precisely
treat
bacterial
infections.
Infection and Drug Resistance,
Год журнала:
2025,
Номер
Volume 18, С. 887 - 902
Опубликована: Фев. 1, 2025
The
inappropriate
prescribing
and
use
of
antibiotics
have
contributed
to
the
emergence
spread
antimicrobial
resistance
(AMR).
In
Zambia,
there
is
a
paucity
information
on
patterns
among
hospitalized
patients
in
level
1
hospitals.
This
study
investigated
antibiotic
five
hospitals
Lusaka,
Zambia.
cross-sectional
utilized
World
Health
Organization
(WHO)
Point
Prevalence
Survey
(PPS)
methodology
in-patients
admitted
before
08:00
a.m.
survey
day
August
2024.
Data
were
analysed
using
IBM
SPSS
version
23.0.
prevalence
inpatients
was
59.0%,
with
ceftriaxone
being
most
prescribed.
Antibiotics
prescribed
mainly
for
paediatrics
male
inpatients.
found
that
53.0%
from
Access
group
while
38.2%
Watch
Access,
Watch,
Reserve
(AWaRe)
classification.
Adherence
national
treatment
guidelines
36.0%,
empirically
without
evidence
culture
sensitivity
tests.
high
low
adherence
findings
this
demonstrate
need
establish
strengthen
stewardship
programs
laboratory
capacity
aid
clinicians
diagnosing,
treating,
managing
across
Asian Journal of Dairy and Food Research,
Год журнала:
2025,
Номер
Of
Опубликована: Янв. 1, 2025
Background:
This
study
seeks
to
evaluate
the
resistance
profiles
of
P.
mirabilis
and
vulgaris
in
isolates
from
African
catfish
Banyuwangi,
East
Java,
Indonesia.
Methods:
A
total
74
samples
were
procured
12
distinct
aquaculture
ponds
Banyuwangi.
The
intentionally
selected
tarpaulin
cement
ponds.
categorized
into
two
groups:
G1,
comprising
with
clinical
evidence
hemorrhage
superficial
ulceration
G2,
consisting
those
without
apparent
symptoms.
Water
quality
assessments
performed
for
each
pond.
Following
this,
isolated
identified
liver
skin
utilizing
MCA
media,
followed
by
Gram
staining
biochemical
assays.
bacterial
sensitivity
tested
beta-lactam
non-beta-lactam
resistance.
Result:
findings
indicated
that
present
catfish,
prevalence
rates
4.05%
(3/74)
10.81%
(8/74),
respectively.
exhibited
extremely
high
against
beta-lactams
antibiotics
Cefadroxil,
Ampicillin,
Penicillin
Oxacillin,
very
antibiotic
Erythromycin
(66.7%).
showed
Oxacillin
Cefadroxil
(both
at
62.5%),
Streptomycin
(50%)
Cefixime
(25%).
factor
influencing
presence
is
type
pond
(p
=
0.044).
It
can
be
concluded
exhibit
highest
most
prevalent
on
Proteus
spp.
isolates.
Additionally,
other
also
observed.
Greater
caution
should
exercised
administration
facilities
safeguard
public
health.
Antibiotic
resistance
is
a
significant
threat
to
public
health
and
drug
development,
driven
largely
by
the
overuse
misuse
of
antibiotics
in
medical
agricultural
settings.
As
bacteria
adapt
evade
current
drugs,
managing
bacterial
infections
has
become
increasingly
challenging,
leading
prolonged
illnesses,
higher
healthcare
costs,
increased
mortality.
This
review
explores
critical
role
fighting
mechanisms
that
enable
resist
them.
Key
discussed
include
carvacrol,
dalbavancin,
quinolones,
fluoroquinolones,
zoliflodacin,
each
with
unique
actions
against
pathogens.
Bacteria
have
evolved
complex
strategies,
such
as
enzyme
production
neutralize
modifying
targets,
using
efflux
pumps
remove
antibiotics,
significantly
reducing
efficacy.
Additionally,
examines
challenges
antibiotic
including
declining
discovery
rate
novel
drugs
due
high
costs
regulatory
complexities.
Innovative
approaches,
structure-based
design,
combination
therapies,
new
delivery
systems,
are
highlighted
for
their
potential
create
compounds
enhanced
action
resistant
strains.
provides
valuable
insights
researchers
developers
aiming
combat
advance
development
robust
antibacterial
therapies
future
security.
Acta Biochimica Polonica,
Год журнала:
2025,
Номер
72
Опубликована: Фев. 27, 2025
Urinary
tract
infections
(UTI)
are
a
significant
problem
among
populations
worldwide.
It
is
mainly
associated
with
the
increasing
incidence
of
recurrence,
complications
and
drug
resistance
uropathogens.
The
aim
this
study
was
to
demonstrate
prevalence
pathogens
causing
urinary
infections.
material
for
data
obtained
from
Mazovian
Specialized
Hospital
(M.S.H)
in
Radom
over
period
2
years.
Urine
collected
hospitalized
patients
UTI.
Statistical
calculations
were
performed
using
statistical
software.
During
period,
3,917
underwent
microbiological
examination
urine,
almost
15%
them
found
be
infected
Based
on
analysis
susceptibility
most
common
uropathogens,
it
shown
that
caused
by
Escherichia
coli
or
Klebsiella
pneumoniae,
others,
often
show
high
fluoroquinolones
β-lactam
antibiotics.
Proteus
mirabilis
strains
have
been
more
resistant
aminoglycosides
than
beta-lactams.
In
case
Pseudomonas
aeruginisa,
predominates.
On
other
hand,
UTI
Acientobacter
baumannii
should
treated
based
results
testing
due
multidrug-resistant
strains.
