Revista Interfaces Saúde Humanas e Tecnologia,
Год журнала:
2024,
Номер
12(3)
Опубликована: Ноя. 10, 2024
The
role
of
the
clinical
pharmacist
in
an
Intensive
Care
Unit
(ICU)
is
utmost
importance
to
ensure
safety,
effectiveness,
and
quality
drug
therapy
for
critically
ill
patients.
In
this
context,
integrative
review
aimed
identify
discuss
services
provided
by
pharmacists
ICUs.
To
end,
scientific
literature
from
past
10
years
on
PubMed
was
conducted.
After
analyzing
production
according
inclusion
exclusion
criteria,
eleven
articles
were
retrieved.
performance
various
types
pharmaceutical
identified,
with
particular
emphasis
pharmacotherapeutic
monitoring,
which
most
clearly
mentioned
category
studies
analyzed.
According
description
activities
articles,
development
health
education
services,
therapeutic
medication
reconciliation,
pharmacotherapy
also
discussed
as
integral
elements
follow-up
process.
Sensors,
Год журнала:
2024,
Номер
24(16), С. 5143 - 5143
Опубликована: Авг. 8, 2024
This
comprehensive
review
delves
into
the
forefront
of
biosensor
technologies
and
their
critical
roles
in
disease
biomarker
detection
therapeutic
drug
monitoring.
It
provides
an
in-depth
analysis
various
types
applications,
including
enzymatic
sensors,
immunosensors,
DNA
elucidating
mechanisms
specific
healthcare
applications.
The
highlights
recent
innovations
such
as
integrating
nanotechnology,
developing
wearable
devices,
trends
miniaturisation,
showcasing
transformative
potential
healthcare.
In
addition,
it
addresses
significant
sensitivity,
specificity,
reproducibility,
data
security
challenges,
proposing
strategic
solutions
to
overcome
these
obstacles.
is
envisaged
that
will
inform
decision-making,
drive
technological
innovation,
enhance
global
outcomes
by
synthesising
multidisciplinary
insights.
Biosensors,
Год журнала:
2024,
Номер
14(11), С. 560 - 560
Опубликована: Ноя. 18, 2024
Wearable
biosensors
are
a
fast-evolving
topic
at
the
intersection
of
healthcare,
technology,
and
personalized
medicine.
These
sensors,
which
frequently
integrated
into
clothes
accessories
or
directly
applied
to
skin,
provide
continuous,
real-time
monitoring
physiological
biochemical
parameters
such
as
heart
rate,
glucose
levels,
hydration
status.
Recent
breakthroughs
in
downsizing,
materials
science,
wireless
communication
have
greatly
improved
functionality,
comfort,
accessibility
wearable
biosensors.
This
review
examines
present
status
biosensor
with
an
emphasis
on
advances
sensor
design,
fabrication
techniques,
data
analysis
algorithms.
We
analyze
diverse
applications
clinical
diagnostics,
chronic
illness
management,
fitness
tracking,
emphasizing
their
capacity
transform
health
facilitate
early
disease
diagnosis.
Additionally,
this
seeks
shed
light
future
healthcare
wellness
by
summarizing
existing
trends
new
advancements.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 9, 2024
Abstract
Current
methods
for
therapeutic
drug
monitoring
(TDM)
have
a
long
turnaround
time
as
they
involve
collecting
patients'
blood
samples
followed
by
transferring
the
to
medical
laboratories
where
sample
processing
and
analysis
are
performed.
To
enable
real‐time
minimally
invasive
TDM,
microneedle
(MN)
biosensor
monitor
levels
of
two
important
antibiotics,
vancomycin
(VAN)
gentamicin
(GEN)
is
developed.
The
MN
composed
hydrogel
(HMN),
an
aptamer‐functionalized
flexible
(Flex)
electrode,
named
HMN‐Flex.
HMN
extracts
dermal
interstitial
fluid
(ISF)
transfers
it
Flex
electrode
sensing
target
antibiotics
happens.
HMN‐Flex
performance
validated
ex
vivo
using
skin
models
well
in
live
rat
animal
models.
Data
leveraged
from
system
construct
pharmacokinetic
profiles
VAN
GEN
compare
these
with
conventional
blood‐based
measurements.
Additionally,
track
pH
patient's
response
during
antibiotic
treatment,
developed
that
employs
colorimetric
method
detect
changes
pH,
HMN‐pH
assay,
whose
has
been
both
vitro
vivo.
Further,
multiplexed
detection
achieved
simultaneously
employing
on
animals.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(15), С. 4398 - 4398
Опубликована: Июль 27, 2024
Advancements
in
psychotropic
therapy
for
pregnant
women
are
pivotal
addressing
maternal
mental
health
during
the
perinatal
period.
Screening
mood
and
anxiety
symptoms
pregnancy
is
recommended
to
enable
early
intervention.
Psychotropic
medications,
including
antidepressants,
benzodiazepines,
antipsychotics,
stabilizers,
commonly
used,
but
challenges
remain
regarding
their
safety
efficacy
pregnancy.
Pregnancy
induces
significant
changes
pharmacokinetics,
necessitating
personalized
dosing
strategies
careful
monitoring.
Real-time
monitoring
technologies,
such
as
smartphone-integrated
platforms
home-based
monitoring,
enhance
accessibility
accuracy.
Prospective
studies
collaboration
among
healthcare
providers
essential
evidence-based
guidelines
optimal
treatment
strategies.
Reducing
stigma
around
crucial
ensure
seek
help
discuss
options,
promoting
understanding
acceptance
within
community.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1137 - 1137
Опубликована: Авг. 28, 2024
Prevention,
assessment,
and
identification
of
drug–drug
interactions
(DDIs)
represent
a
challenge
for
healthcare
professionals,
especially
in
nosocomial
settings.
This
narrative
review
aims
to
provide
thorough
assessment
the
most
clinically
significant
DDIs
antibiotics
used
healthcare-associated
infections.
Complex
poly-pharmaceutical
regimens,
targeting
multiple
pathogens
or
one
pathogen
presence
another
comorbidity,
have
an
increased
predisposition
result
life-threatening
DDIs.
Recognising,
assessing,
limiting
infections
offers
promising
opportunities
improving
health
outcomes.
The
objective
this
is
clinicians
with
practical
advice
prevent
mitigate
DDIs,
aim
increasing
safety
effectiveness
therapy.
DDI
management
importance
individualising
therapy
according
patient,
disease
status,
associated
comorbidities.
Frontiers in Neurology,
Год журнала:
2025,
Номер
16
Опубликована: Март 14, 2025
Epilepsy
is
a
common
neurological
disorder
associated
with
seizures
that
impact
patients'
quality
of
life.
Treatment
includes
antiepileptic
drugs
(AEDs),
each
effective
only
at
specific
dose,
making
continuous
therapeutic
drug
monitoring
(TDM)
useful
in
clinical
cases
under
inpatient
conditions.
Conventional
liquid
chromatography-tandem
mass
spectrometry
(LC-MS/MS)
lacks
automation
for
24/7
operation,
limiting
applicability.
This
study
validates
fully
automated
AED
system
using
the
Clinical
Laboratory
Automated
Sample
Preparation
Module
2030
(CLAM-2030).
The
method
was
validated
according
to
U.S.
Food
and
Drug
Administration
(FDA)
European
Medicines
Agency
(EMA)
guidelines
by
evaluating
linearity,
precision,
accuracy,
carry
over,
matrix
effects,
calibration
stability.
Twenty-six
AEDs
were
quantified
plasma
multiple
reaction
(MRM)
transitions
positive
negative
electrospray
ionization
modes.
preparation
automated:
20
μL
methanol
used
wet
column,
followed
internal
standard
100
acetonitrile
protein
precipitation.
supernatant
filtered
injected
directly
into
LC
system.
Chromatographic
separation
achieved
within
4.5
min
C18
column
(2.1
×
50
mm,
2.7
μm)
gradient
conditions
mobile
phase
0.2
mM
ammonium
formate
0.002%
formic
acid.
demonstrated
excellent
linearity
over
concentration
ranges
(R
2
>
0.99
all
analytes).
Within-run
imprecision
<15%
lower
limit
quantitation
(LLOQ),
while
between-run
<10%
most
AEDs.
Accuracy
±10%
nominal
concentrations
control
(QC)
levels.
Matrix
effects
acceptable
limits
(<30%
variation)
23
26
analytes,
compensatory
corrections
applied
carbamazepine-D10,
felbamate-D4,
levetiracetam-D6.
Carry
negligible
[<2%
except
retigabine
N-desmethylselegiline
(NDMS),
which
remained
below
6.5%].
Calibration
stability
maintained
5
days
peak
area
variation
<10%.
An
interlaboratory
comparison
(ring
test)
showed
relative
deviation
<20%
analytes.
establishes
robust,
automated,
high-throughput
setting.
CLAM-2030-LCMS-8060NX
enables
reliable
TDM
minimal
technical
expertise,
ensuring
optimized
therapy
improved
patient
outcomes.
National Journal of Pharmacology and Therapeutics,
Год журнала:
2025,
Номер
3(1), С. 15 - 19
Опубликована: Янв. 1, 2025
Abstract
Therapeutic
drug
monitoring
(TDM),
which
customizes
medication
doses
according
to
observed
plasma
concentrations,
is
an
essential
technique
for
pharmacotherapy
optimization.
This
method
reduces
side
effects,
improves
treatment
efficacy,
and
takes
into
account
the
patient
population-specific
variations
in
pharmacokinetics
pharmacodynamics
(PKs/PDs).
TDM
ensures
that
PK/PD
goals
are
quickly
reached
maintained
critical
care
precision
medicine.
Its
uses
have
grown
include
biomarker-guided
cancer
treatments,
tailored
immunosuppression
transplantation,
antimicrobial
stewardship.
The
application
of
still
underutilized
India
despite
country’s
expanding
pharmaceutical
research
development
scene.
In
past,
services
were
first
offered
by
organizations
such
as
King
Edward
Memorial
Hospital
Mumbai
late
1980s.
Christian
Medical
College,
Vellore,
Postgraduate
Institute
Education
Research,
Chandigarh,
next
follow.
Today,
academic
clinical
centers
continue
provide
cost-effective
services,
highlighting
its
vital
role
advancing
pharmacology
improving
outcomes.
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 30, 2025
Abstract
Precision
medicines,
or
those
medicines
that
are
tailored
to
individual
genetic,
molecular,
physiologic,
behavioral,
and/or
exposure
profiles,
being
developed
at
a
rapid
pace.
However,
just
how
precise
these
interventions
in
terms
of
their
mechanisms
action
(MOAs),
clinical
effects,
and
utility
different
individuals,
hard
anticipate
with
current
preclinical
research
trials
strategies.
To
understand
various
genes,
processes,
organs,
phenotypes,
etc.
may
be
impacted
by
an
intervention,
as
well
many
people
might
benefit
from
it,
appropriate
data
on
living
human
beings
needs
collected
part
built-for-purpose
trials.
Asian Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
19(6), С. 100980 - 100980
Опубликована: Окт. 28, 2024
Buoyed
by
the
discovery
of
small-molecule
tyrosine
kinase
inhibitors
(smTKIs),
significant
impact
has
been
made
in
cancer
chemotherapeutics.
However,
some
these
agents
still
encounter
off-target
toxicities
and
suboptimal
efficacies
due
to
their
inferior
biopharmaceutical
and/or
pharmacokinetic
properties.
Almost
all
molecules
exhibit
inter-
intra-patient
variations
plasma
concentration-time
profiles.
Thus,
therapeutic
drug
monitoring,
dose
adjustments
precision
medicine
are
being
contemplated
clinicians.
Complex
formulations
or
nanoformulation-based
delivery
systems
offer
promising
approaches
provide
encapsulation
spatiotemporal
control
over
release,
overcoming
limitations
improving
outcomes.
In
this
context,
present
review
comprehensively
tabulates
critically
analyzes
relevant
properties
(T
