Shenling Baizhu powder attenuates lard diet in a fatigued state-induced diarrhea via targeting microbial metabolites short chain fatty acids-mediated lipid metabolism
3 Biotech,
Год журнала:
2024,
Номер
14(9)
Опубликована: Авг. 16, 2024
Язык: Английский
Overview of current research on traditional Chinese medicine in skin disease treatment: a bibliometric analysis from 2014 to 2024
Pharmaceutical Biology,
Год журнала:
2025,
Номер
63(1), С. 27 - 41
Опубликована: Янв. 2, 2025
Context
Recent
research
has
revealed
significant
advancements
in
the
field
of
traditional
Chinese
medicine
(TCM)
for
skin
diseases.
However,
there
is
a
lack
visualization
analysis
within
this
domain.
Язык: Английский
Alterations of gut microbiota for the onset and treatment of psoriasis: A systematic review
European Journal of Pharmacology,
Год журнала:
2025,
Номер
unknown, С. 177521 - 177521
Опубликована: Март 1, 2025
Язык: Английский
Integrating Transcriptomics and Network Pharmacology to Reveal the Effect and Mechanism of Bai-Jie-Jing-Xie Ointment on Improving Skin Inflammation of Psoriasis
Journal of Ethnopharmacology,
Год журнала:
2025,
Номер
unknown, С. 119680 - 119680
Опубликована: Март 1, 2025
Язык: Английский
Development and trends in metabolomics studies in psoriasis: A bibliometric analysis of related research from 2011 to 2024
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29794 - e29794
Опубликована: Апрель 1, 2024
Psoriasis
is
a
chronic,
inflammatory
skin
disease
with
autoimmune
characteristics.
Recent
research
has
made
significant
progress
in
the
field
of
psoriasis
metabolomics.
However,
there
lack
bibliometric
analysis
on
metabolomics
psoriasis.
The
objective
this
study
to
utilize
bibliometrics
present
comprehensive
understanding
knowledge
structure
and
hotspots
within
Язык: Английский
Effects of Licorice Functional Components Intakes on Blood Pressure: A Systematic Review with Meta-Analysis and NETWORK Toxicology
Nutrients,
Год журнала:
2024,
Номер
16(21), С. 3768 - 3768
Опубликована: Ноя. 2, 2024
Objective:
To
investigate
the
effects
of
licorice
functional
ingredient
intake
on
blood
pressure,
explore
its
potential
mechanisms
action,
and
provide
safety
information
for
personalized
nutritional
interventions
in
special
populations
application
licorice-derived
foods.
Methods:
PubMed,
Cochrane
Library,
Medline,
Embase,
EBSCO,
ScienceDirect,
Web
Science
databases
were
searched
from
inception
to
31
August
2024.
Randomized
controlled
trials
(RCTs)
investigating
or
components
included.
The
range
continuous
variables
was
assessed
using
weighted
mean
difference
(WMD)
with
95%
confidence
intervals.
Genes
associated
hypertension
screened
an
online
database.
Machine
learning,
receiver
operating
characteristic(ROC)
curve
analysis,
molecular
docking,
gene
set
enrichment
analysis
(GSEA)
employed
underlying
licorice-induced
pressure
fluctuations.
Results:
Eight
RCTs
(541
participants)
included
meta-analysis,
which
indicated
containing
glycyrrhizic
acid
(GA)
as
main
component
increased
systolic
(SBP)
diastolic
(DBP)
(SBP:
WMD
[95%
CI]
=
3.48
[2.74,
4.21],
p
<
0.001;
DBP:
1.27
[0.76,
1.78],
0.001).
However,
dominated
by
flavonoids(LF)
had
no
significant
effect
SBP
DBP
0.58
[−1.15,
2.31],
0.511;
0.17
[−1.53,
1.88],
0.843).
Three
machine
learning
algorithms
identified
five
biomarkers
hypertension:
calmodulin
3
(CALM3),
cluster
differentiation
9
(CD9),
growth
factor
independence
1B
transcriptional
repressor
(GFI1B),
myosin
light
chain
kinase
(MYLK),
Ras
suppressor-1
(RSU1).
After
removing
lower
validity
reliability,
GFI1B,
MYLK,
RSU1
selected
subsequent
analysis.
network
toxicology
results
suggested
that
GA
metabolite
glycyrrhetinic
may
act
RSU1,
influencing
fluctuations
modulating
nitrogen
metabolism
signaling
pathways.
Conclusions:
There
distinct
differences
pressure.
Functional
constituents
shown
increase
both
DBP,
whereas
those
LF
did
not
exhibit
hypertensive
mechanism
involve
modulation
regulate
metabolic
Язык: Английский
The RAGE Pathway in Skin Pathology Development: A Comprehensive Review of Its Role and Therapeutic Potential
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13570 - 13570
Опубликована: Дек. 18, 2024
The
receptor
for
advanced
glycation
end-products
(RAGE),
a
member
of
the
immunoglobulin
superfamily,
is
expressed
in
various
cell
types
and
mediates
cellular
responses
to
wide
range
ligands.
activation
RAGE
triggers
complex
signaling
pathways
that
drive
inflammatory,
oxidative,
proliferative
responses,
which
are
increasingly
implicated
pathogenesis
skin
diseases.
Despite
its
well-established
roles
conditions
such
as
diabetes,
cancer,
chronic
inflammation,
contribution
pathologies
remains
underexplored.
This
review
synthesizes
current
findings
on
RAGE’s
involvement
pathophysiology
diseases,
including
psoriasis,
atopic
dermatitis,
lichen
planus,
focusing
inflammatory
signaling,
tissue
remodeling,
cancer
progression.
Additionally,
it
examines
RAGE-modulating
treatments
investigated
dermatological
contexts,
highlighting
their
potential
therapeutic
options.
Given
significance
variety
conditions,
further
research
into
mediated
may
uncover
new
opportunities
targeted
interventions
skin-specific
signaling.
Язык: Английский
Efficacy and action mechanisms of compound Shen Chan decoction on experimental models of atopic dermatitis
International Immunopharmacology,
Год журнала:
2024,
Номер
137, С. 112479 - 112479
Опубликована: Июнь 19, 2024
Shen
chan
decoction
(SCD)
as
a
significant
Traditional
Chinese
medicine
(TCM)
to
treat
atopic
dermatitis
(AD),
but
its
mechanism
of
action
has
not
been
clarified,
so
we
started
the
present
study,
first
possible
effects
SCD
on
AD
were
predicted
using
network
pharmacology.
Next,
dinitrochlorobenzene
was
used
establish
mouse
model
AD.
After
successful
modelling,
administered
intragastrically
mice.
Eventually,
KEGG
pathway
enrichment
analysis
indicated
that
improved
mainly
through
inflammation
and
gut
microbiota.
The
experimental
findings
revealed
treatment
attenuated
symptoms
downregulate
characteristic
immune
factors,
namely
IL-4,
IL-6
IgE.
Moreover,
it
promoted
balance
between
Th1/Th2
cells.
Furthermore,
itch
signaling
pathways
involving
H1R/PAR-2/TRPV1
inhibited.
16S
rRNA
sequencing
results
administration
influenced
Firmicutes/Bacteroidetes
ratio
at
phylum
level
by
augmenting
relative
proportions
Lactobacillaceae
Muribaculaceae
family
genus
levels,
while
decreasing
abundances
Lactococcus
Ruminococcus.
These
suggest
internal
is
an
effective
therapeutic
approach
for
We
may
be
alternative
therapy
AD.Additionally,
could
offer
valuable
insights
into
pathogenesis
development
innovative
agents.
Язык: Английский