Preconditioning with Ginsenoside Rg3 mitigates cardiac injury induced by high-altitude hypobaric hypoxia exposure in mice by suppressing ferroptosis through inhibition of the RhoA/ROCK signaling pathway
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
337, С. 118861 - 118861
Опубликована: Сен. 24, 2024
Язык: Английский
Sodium Hydrosulfide Protects Rats from Hypobaric-Hypoxia-Induced Acute Lung Injury
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(19), С. 10734 - 10734
Опубликована: Окт. 5, 2024
Hydrogen
sulfide
(H2S),
as
a
key
gas
signaling
molecule,
plays
an
important
role
in
regulating
various
diseases,
with
appropriate
concentrations
providing
antioxidative,
anti-inflammatory,
and
anti-apoptotic
effects.
The
specific
of
H2S
acute
hypoxic
injury
remains
to
be
clarified.
This
study
focuses
on
the
donor
sodium
hydrosulfide
(NaHS)
explores
its
protective
effects
mechanisms
against
lung
injury.
First,
mouse
hypoxia
models
were
established
evaluate
H2S’s
protection
tolerance.
Next,
rat
model
(ALI)
induced
by
at
6500
m
above
sea
level
for
72
h
was
created
assess
mechanisms.
Evaluation
metrics
included
blood
analysis,
routine
indicators,
water
content,
tissue
pathology.
Additionally,
LC-MS/MS
bioinformatic
analyses
combined
performing
quantitative
proteomics
tissues
from
normoxic
control
group,
group
NaHS
treatment
preliminarily
explore
H2S.
Further,
enzyme-linked
immunosorbent
assays
(ELISA)
used
measure
oxidative
stress
markers
inflammatory
factors
tissues.
Lastly,
Western
blot
analysis
performed
detect
Nrf2,
HO-1,
P-NF-κB,
NF-κB,
HIF-1α,
Bcl-2,
Bax
proteins
Results
showed
that
exhibited
significant
anti-hypoxic
models,
effectively
modulating
indicators
ALI
rats,
reducing
pulmonary
edema,
improving
pathology,
alleviating
stress,
responses,
apoptosis
levels.
Язык: Английский
Ginsenoside Rg1 Prevents and Treats Acute Pulmonary Injury Induced by High-Altitude Hypoxia
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12051 - 12051
Опубликована: Ноя. 9, 2024
This
study
aimed
to
investigate
the
protective
effects
of
ginsenoside
Rg1
on
high-altitude
hypoxia-induced
acute
lung
injury
(ALI)
and
elucidated
its
molecular
targets
related
pathways,
specifically
association
with
fluid
shear
stress
pathway.
Using
a
combination
bioinformatics
analysis
both
in
vivo
vitro
experiments,
we
assessed
role
mitigating
physiological
biochemical
disturbances
induced
by
hypoxia.
In
measured
arterial
blood
gas
parameters,
levels
inflammatory
cells
cytokines,
erythrocyte
platelet
conducted
histological
rats.
The
experiments
utilized
human
pulmonary
microvascular
endothelial
(HPMECs)
A549
examine
cell
viability,
intracellular
reactive
oxygen
species
(ROS)
Ca
Язык: Английский
Decreased Work Capability Related to High-Altitude Exposure
Risk Management and Healthcare Policy,
Год журнала:
2024,
Номер
Volume 17, С. 2839 - 2849
Опубликована: Ноя. 1, 2024
The
unique
environment
of
high
altitude
can
affect
the
work
capacity
those
not
accustomed
to
it,
and
in
some
cases,
it
even
endanger
their
lives.
Studying
effect
high-altitude
exposure
on
is
important.
Still,
there
are
few
reviews
this
topic.
We
aimed
summarize
parameters
used
evaluate
capability
a
environment,
potential
pathophysiological
mechanisms,
available
pharmacological
non-pharmacological
strategies
for
improvement.
Язык: Английский
[Status of Research on Molecular Mechanisms and Management of Acute Mountain Sickness].
PubMed,
Год журнала:
2024,
Номер
55(6), С. 1418 - 1423
Опубликована: Ноя. 20, 2024
Acute
mountain
sickness
(AMS),
a
condition
characterized
primarily
by
symptoms
such
as
headache
and
nausea,
has
high
incidence
seriously
affects
the
life
health
of
individuals
undertaking
rapid
ascensions
to
altitudes.
The
main
pathophysiological
manifestations
AMS
include
cerebral
vasodilation
transient
increases
in
intracranial
pressure,
with
severe
cases
potentially
incurring
edema.
occurrence
development
is
associated
factors
susceptibility,
physiological
state,
psychological
state
an
individual.
molecular
mechanisms
involved
inflammatory
responses,
oxidative
stress,
immune
regulation,
energy
metabolism
at
levels
genes,
proteins,
metabolism.
management
includes
both
prevention
treatment
strategies.
This
article
provides
comprehensive
discussion
from
several
aspects,
including
diagnosis,
manifestations,
susceptibility
factors,
mechanisms,
Язык: Английский