Nanomaterial-Based Strategies to Combat Antibiotic Resistance: Mechanisms and Applications

Antibiotics, Год журнала: 2025, Номер 14(2), С. 207 - 207

Опубликована: Фев. 18, 2025

The rapid rise of antibiotic resistance has become a global health crisis, necessitating the development innovative strategies to combat multidrug-resistant (MDR) pathogens. Nanomaterials have emerged as promising tools in this fight, offering unique physicochemical properties that enhance efficacy, overcome mechanisms, and provide alternative therapeutic approaches. This review explores diverse nanomaterial-based used resistance, focusing on their mechanisms action practical applications. such metal nanoparticles, carbon-based nanomaterials, polymeric nanostructures exhibit antibacterial through various pathways, including generation reactive oxygen species (ROS), disruption bacterial membranes, enhancement delivery. Additionally, ability nanomaterials bypass traditional biofilm formation efflux pumps, been demonstrated numerous studies. also discusses synergistic effects observed when are combined with conventional antibiotics, leading increased susceptibility reduced required dosages. By highlighting recent advancements clinical applications nanomaterial-antibiotic combinations, paper provides comprehensive overview how reshaping future therapies. Future research directions challenges, toxicity scalability, addressed guide safer, more effective treatments.

Язык: Английский

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Sustainable green synthesis of silver nanoparticles for safer biomedical application

Journal of environmental chemical engineering, Год журнала: 2025, Номер unknown, С. 115998 - 115998

Опубликована: Фев. 1, 2025

Язык: Английский

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Nanotechnology for Healthcare: Plant-Derived Nanoparticles in Disease Treatment and Regenerative Medicine

Pharmaceuticals, Год журнала: 2024, Номер 17(12), С. 1711 - 1711

Опубликована: Дек. 18, 2024

Nanotechnology has revolutionised biomedical research, offering innovative healthcare solutions. Plant-based nanotechnology is emerging as a sustainable alternative, minimising environmental impacts and enhancing therapeutic effectiveness. This paper explores the potential of plant-derived nanoparticles (PNPs) in medicine, highlighting their biocompatibility, multifunctionality, eco-friendliness. PNPs, synthesised through green methods, have demonstrated promising applications drug delivery, cancer therapy, antimicrobial treatments, tissue regeneration. Their unique properties, such high surface area bioactive components, enable improved targeting, controlled release, reducing side effects treatment efficacy. Additionally, compounds’ inherent antioxidant retained within platinum (PNPs), present opportunities for combating resistance promoting wound healing. Despite potential, challenges remain standardising PNP synthesis, ensuring consistency, scaling up production industrial applications. review emphasises need further research on toxicity, regulatory frameworks to fully harness capabilities clinical commercial represents promising, greener alternative advancing solutions, aligning with global sustainability goals.

Язык: Английский

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Efficacy of different microbial synthesized silver nanoparticles alone and in combination in single- and multi-species of Candida albicans and Pseudomonas aeruginosa biofilm inhibition and in downregulation of the HWP1 and PELA gene expression

Materials Today Communications, Год журнала: 2025, Номер 42, С. 111507 - 111507

Опубликована: Янв. 1, 2025

Язык: Английский

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Enhanced hemocompatibility, antimicrobial and anti-inflammatory properties of biomolecules stabilized AgNPs with cytotoxic effects on cancer cells

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 7, 2025

In the current research, we developed a safe method using Iranian yarrow extract for synthesis of silver nanoparticles (IY-AgNPs) as reducing and stabilizing agents in different conditions. The prepared stabilized IY-AgNPs under optimal conditions were characterized FT-IR, XRD, TEM, UV-vis techniques. Also, blood-clotting, hemolytic, antioxidant, bactericidal and, fungicidal properties, cytotoxicity effects inhibition protein denaturation efficiency assessed vitro. with spherical shape an average particle size 19. 25 ± 7.9 nm did not show any hemolytic potential below 1000 µg/mL. These hemo-compatible NPs showed good blood-clotting ability by clotting time (6 min relative to control). particles excellently inhibited bovine serum albumin (BSA) 69.3–80.7% at concentrations ranging from 31.25 500 µg/mL compared reference drug. outcomes that IC50 values 12.5 against A375 cells between 50 MCF-7 cancer cells. addition, Escherichia coli, Pseudomonas aeruginosa Staphylococcus aureus (especially), Candida albicans. Biosynthesized indicated significant antioxidant activity (63.2%) concentration 350 attained results suggested bio/hemo-compatible may be promising candidate applications medicinal fields (particularly wound healing) anti-bleeding, antimicrobial, anti-inflammatory, anticancer agents.

Язык: Английский

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The Role of Nanoparticles in Wine Science: Innovations and Applications

Nanomaterials, Год журнала: 2025, Номер 15(3), С. 175 - 175

Опубликована: Янв. 23, 2025

Viticulture, the science of growing, cultivating, and harvesting grapes, enology, art making wine, are rapidly evolving through innovative approaches aimed at improving quality efficiency grape wine production. This review explores emerging use nanoparticles, in particular gold, silver, magnetic to improve quality, safety, sustainability both growing winemaking processes. The unique properties these such as their small size, high surface area, distinct chemical properties, enable them address key challenges within industry. In viticulture, nanoparticles have shown potential protecting vines from pathogens, optimizing yield, quality. a significant contribution microbial control, reducing spoilage refining analysis techniques, leading improved product safety. also highlights synergy between different types diverse applications, control production packaging solutions. addition, reduce dependence on agrochemicals production, which is promising avenue for future research. However, integration viticulture enology poses regulatory safety challenges, including leach into products. Further research advances essential ensure safe effective technologies winemaking. Overall, offer benefits industry, driving improvements efficiency, sustainability,

Язык: Английский

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Investigation of temperature jump, first and second-order velocity slip effects on blood-based ternary nanofluid flow in convergent/divergent channels

International Journal of Numerical Methods for Heat &amp Fluid Flow, Год журнала: 2025, Номер unknown

Опубликована: Фев. 3, 2025

Purpose High surface area-to-volume ratios make nanoparticles ideal for cancer heat therapy and targeted medication delivery. Moreover, ternary nanofluids (TNFs) may possess superior thermophysical properties compared to mono- hybrid due their synergistic effects. In light of this information, the objective article is examine blood-based TNF flow within convergent/divergent channels under velocity slip temperature jump. Design/methodology/approach Leading partial differential equations corresponding problem are transformed into a system nonlinear ordinary by using similarity variables. The bvp4c code that uses finite difference method used obtain numerical solution. Findings effect change depending on characteristics near wall. proportions become important control flow. When was used, an increase in Nusselt number between 4.75% 6.10% observed at low Reynolds numbers. At high numbers, reduce skin friction coefficient values some special conditions. Importantly, effects second-order engineering parameters were also investigated. Furthermore, increases with increasing shape factor. Research limitations/implications Obtained results study can be beneficial both nature engineering, especially blood veins. Originality/value main innovations usage examination factor slip.

Язык: Английский

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Recent advances of silver nanoparticle-based polymer nanocomposites for biomedical applications

RSC Advances, Год журнала: 2025, Номер 15(11), С. 8480 - 8505

Опубликована: Янв. 1, 2025

Silver nanoparticle-polymer nanocomposites (AgNP-PNCs) represent a transformative advancement in biomedical material science, integrating the potent antimicrobial properties of AgNPs with structural versatility polymer matrices. This synergy enables enhanced infection control, mechanical stability, and controlled drug delivery, making these highly suitable for applications such as wound healing, medical coatings, tissue engineering, biosensors. Recent progress synthesis functionalization has led to greater control over particle morphology, dispersion, optimizing AgNP-PNCs clinical translational applications. However, challenges related cytotoxicity, long-term immune response, scalability persist, necessitating systematic improvements surface functionalization, hybridization strategies, biocompatibility assessments. review critically evaluates latest advancements AgNP-PNC development, focusing on their techniques, regulatory considerations, emerging strategies overcome challenges. Additionally, it discusses preclinical aspects, including commercialization barriers frameworks FDA EMA guidelines, ensuring comprehensive outlook feasibility. By bridging gap between innovation practical application, this investigates potential advancing next-generation materials.

Язык: Английский

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Eco-friendly Nanoparticle Phytosynthesis via Plant Extracts: Mechanistic Insights, Recent Advances, and Multifaceted Uses

Nano TransMed, Год журнала: 2025, Номер unknown, С. 100080 - 100080

Опубликована: Март 1, 2025

Язык: Английский

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Fabrication of gelatine/fucoidan nanogel-coated silver nanoparticles for the treatment of wound healing therapy and nursing care

Regenerative Therapy, Год журнала: 2025, Номер 29, С. 282 - 291

Опубликована: Апрель 1, 2025

Язык: Английский

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