Guanethidine Enhances the Antibacterial Activity of Rifampicin Against Multidrug-Resistant Bacteria DOI Creative Commons
Xiaoou Zhao, Zhenxue Zhang, Leying Liu

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2207 - 2207

Published: Oct. 31, 2024

The escalating global threat of antibiotic resistance necessitates innovative strategies, such as the combination antibiotics with adjuvants. Monotherapy rifampicin is more likely to induce in pathogens compared other antibiotics. Herein, we found that antihypertensive drug guanethidine enhanced activity against certain clinically resistant Gram-negative bacteria, resulting a reduction up 128-fold minimum inhibitory concentration. In infected animal models, this has achieved treatment benefits, including increased survival and decreased bacterial burden. antimicrobial mechanism synergy involves disruption outer membrane leading dissipation proton motive force. This results an increase reactive oxygen species ATP synthesis, severely disturbing energy metabolism ultimately increasing mortality. summary, potential become novel adjuvant for rifampicin, offering new option clinical infections.

Language: Английский

Emerging Threats: Antimicrobial Resistance in Extended-Spectrum Beta-Lactamase and Carbapenem-Resistant Escherichia coli DOI

Mamdouh S ALjohni,

Mohammad Harun‐Ur‐Rashid, Samy Selim

et al.

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107275 - 107275

Published: Jan. 1, 2025

Language: Английский

Citations

1
Advancements in Antibacterial Therapy: Feature Papers DOI Creative Commons
Giancarlo Angeles Flores,

Gaia Cusumano,

Roberto Venanzoni

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(3), P. 557 - 557

Published: March 1, 2025

Antimicrobial resistance (AMR) is a growing global health crisis that threatens the efficacy of antibiotics and modern medical interventions. The emergence multidrug-resistant (MDR) pathogens, exacerbated by misuse in healthcare agriculture, underscores urgent need for innovative solutions. (1) Background: AMR arises from complex interactions between human, animal, environmental health, further aggravated overuse inadequate regulation antibiotics. Conventional treatments are increasingly ineffective, necessitating alternative strategies. Emerging approaches, including bacteriophage therapy, antimicrobial peptides (AMPs), nanotechnology, microbial extracellular vesicles (EVs), CRISPR-based antimicrobials, provide novel mechanisms complement traditional combating resistant pathogens. (2) Methods: This review critically analyzes advanced antibacterial strategies conjunction with systemic reforms such as stewardship programs, One Health framework, surveillance tools. These methods can enhance detection, guide interventions, promote sustainable practices. Additionally, economic, logistical, regulatory challenges impeding their implementation evaluated. (3) Results: technologies, CRISPR exhibit promising potential targeting mechanisms. However, disparities resource distribution barriers hinder widespread adoption. Public–private partnerships agriculture practices critical to overcoming these obstacles. (4) Conclusions: A holistic integrated approach essential mitigating impact AMR. By aligning therapeutic policies, fostering interdisciplinary collaboration, ensuring equitable distribution, we develop response this 21st-century challenge.

Language: Английский

Citations

1
Multifunctional Properties of Dy2O3-Doped ZnO Nanoparticles: Optical, Dielectric, and Antibacterial Performance DOI

Taghreed Almuatiri,

Ridha Hamdi, Essam Kotb

et al.

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

Citations

0
Occurrence of Antibiotic-resistant Proteus mirabilis and Proteus vulgaris in African Catfish (Clarias sp.) Isolates in Banyuwangi, East Java, Indonesia DOI Open Access

Prima Ayu Wibawati,

Mohammad Faizal Ulkhaq, Jiun‐Yan Loh

et al.

Asian Journal of Dairy and Food Research, Journal Year: 2025, Volume and Issue: Of

Published: Jan. 1, 2025

Background: This study seeks to evaluate the resistance profiles of P. mirabilis and vulgaris in isolates from African catfish Banyuwangi, East Java, Indonesia. Methods: A total 74 samples were procured 12 distinct aquaculture ponds Banyuwangi. The intentionally selected tarpaulin cement ponds. categorized into two groups: G1, comprising with clinical evidence hemorrhage superficial ulceration G2, consisting those without apparent symptoms. Water quality assessments performed for each pond. Following this, isolated identified liver skin utilizing MCA media, followed by Gram staining biochemical assays. bacterial sensitivity tested beta-lactam non-beta-lactam resistance. Result: findings indicated that present catfish, prevalence rates 4.05% (3/74) 10.81% (8/74), respectively. exhibited extremely high against beta-lactams antibiotics Cefadroxil, Ampicillin, Penicillin Oxacillin, very antibiotic Erythromycin (66.7%). showed Oxacillin Cefadroxil (both at 62.5%), Streptomycin (50%) Cefixime (25%). factor influencing presence is type pond (p = 0.044). It can be concluded exhibit highest most prevalent on Proteus spp. isolates. Additionally, other also observed. Greater caution should exercised administration facilities safeguard public health.

Language: Английский

Citations

0
Chronic Endometritis and Antimicrobial Resistance: Towards a Multidrug-Resistant Endometritis? An Expert Opinion DOI Creative Commons
Francesco Di Gennaro, Giacomo Guido, Luisa Frallonardo

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(1), P. 197 - 197

Published: Jan. 17, 2025

Chronic endometritis (CE) is a persistent inflammatory condition of the endometrium characterized by abnormal infiltration plasma cells into endometrial stroma. Frequently associated with repeated implantation failure, recurrent pregnancy loss, and infertility, CE significantly impacts women's health, contributing to conditions such as uterine bleeding endometriosis. Treatment typically involves antibiotic therapy; however, efficacy these treatments increasingly compromised rise antimicrobial resistance (AMR). This paper examines critical links between AMR CE, proposing strategies enhance clinical management optimize treatment outcomes.

Language: Английский

Citations

0
Combating antibiotic resistance: mechanisms, challenges, and innovative approaches in antibacterial drug development DOI Creative Commons

Aiswarya Rajesh,

Sunita Pawar,

Kruthi Doriya

et al.

Published: Jan. 26, 2025

Antibiotic resistance is a significant threat to public health and drug development, driven largely by the overuse misuse of antibiotics in medical agricultural settings. As bacteria adapt evade current drugs, managing bacterial infections has become increasingly challenging, leading prolonged illnesses, higher healthcare costs, increased mortality. This review explores critical role fighting mechanisms that enable resist them. Key discussed include carvacrol, dalbavancin, quinolones, fluoroquinolones, zoliflodacin, each with unique actions against pathogens. Bacteria have evolved complex strategies, such as enzyme production neutralize modifying targets, using efflux pumps remove antibiotics, significantly reducing efficacy. Additionally, examines challenges antibiotic including declining discovery rate novel drugs due high costs regulatory complexities. Innovative approaches, structure-based design, combination therapies, new delivery systems, are highlighted for their potential create compounds enhanced action resistant strains. provides valuable insights researchers developers aiming combat advance development robust antibacterial therapies future security.

Language: Английский

Citations

0
Point Prevalence Survey of Antibiotic Use in Level 1 hospitals in Zambia: Future Prospects for Antimicrobial Stewardship Programs DOI Creative Commons
Steward Mudenda, Adriano Focus Lubanga, Shazia Jamshed

et al.

Infection and Drug Resistance, Journal Year: 2025, Volume and Issue: Volume 18, P. 887 - 902

Published: Feb. 1, 2025

The inappropriate prescribing and use of antibiotics have contributed to the emergence spread antimicrobial resistance (AMR). In Zambia, there is a paucity information on patterns among hospitalized patients in level 1 hospitals. This study investigated antibiotic five hospitals Lusaka, Zambia. cross-sectional utilized World Health Organization (WHO) Point Prevalence Survey (PPS) methodology in-patients admitted before 08:00 a.m. survey day August 2024. Data were analysed using IBM SPSS version 23.0. prevalence inpatients was 59.0%, with ceftriaxone being most prescribed. Antibiotics prescribed mainly for paediatrics male inpatients. found that 53.0% from Access group while 38.2% Watch Access, Watch, Reserve (AWaRe) classification. Adherence national treatment guidelines 36.0%, empirically without evidence culture sensitivity tests. high low adherence findings this demonstrate need establish strengthen stewardship programs laboratory capacity aid clinicians diagnosing, treating, managing across

Language: Английский

Citations

0
Drug susceptibility of uropathogens isolated from patients treated at the Mazovian Specialized Hospital in Radom DOI Creative Commons
Zuzanna Trześniewska-Ofiara, Mariola Mendrycka, Agnieszka Woźniak-Kosek

et al.

Acta Biochimica Polonica, Journal Year: 2025, Volume and Issue: 72

Published: Feb. 27, 2025

Urinary tract infections (UTI) are a significant problem among populations worldwide. It is mainly associated with the increasing incidence of recurrence, complications and drug resistance uropathogens. The aim this study was to demonstrate prevalence pathogens causing urinary infections. material for data obtained from Mazovian Specialized Hospital (M.S.H) in Radom over period 2 years. Urine collected hospitalized patients UTI. Statistical calculations were performed using statistical software. During period, 3,917 underwent microbiological examination urine, almost 15% them found be infected Based on analysis susceptibility most common uropathogens, it shown that caused by Escherichia coli or Klebsiella pneumoniae, others, often show high fluoroquinolones β-lactam antibiotics. Proteus mirabilis strains have been more resistant aminoglycosides than beta-lactams. In case Pseudomonas aeruginisa, predominates. On other hand, UTI Acientobacter baumannii should treated based results testing due multidrug-resistant strains.

Language: Английский

Citations

0
Synthesis, characterization, biological and computational studies of Ni(II) compounds with flexible carboxylic acids DOI

Jyoti,

Sumit Mittal, Anee Mohanty

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141961 - 141961

Published: March 1, 2025

Language: Английский

Citations

0
Presence, Pathogenicity, Antibiotic Resistance, and Virulence Factors of Escherichia coli: A Review DOI Creative Commons
Natalie Naidoo, Oliver T. Zishiri

Bacteria, Journal Year: 2025, Volume and Issue: 4(1), P. 16 - 16

Published: March 11, 2025

Escherichia coli (E. coli) is a Gram-negative, commensal/pathogenic bacteria found in human intestines and the natural environment. Pathogenic E. known as extra-intestinal pathogenic (ExPEC) or intestinal (InPEC). InPEC strains are separated into six groups, enteropathogenic (EPEC), enterotoxigenic (ETEC), enteroinvasive (EIEC), enteroaggregative (EAEC), enterohaemorrhagic (EHEC), diffusely adherent (DAEC), that have various virulence factors cause infection. Virulence refer to combination of distinctive accessory traits affect broad range cellular processes pathogens. There two important directly interact with cells diarrhoeal diseases within intestines: adhesion colonization exotoxins. crucial for overcome host’s immune system result antibiotic resistance. Antibiotics used combat symptoms duration infection by coli. However, misuse overuse antibiotics led global concern Currently, colistin last-resort drug fight caused this bacterium. Antibiotic resistance can be achieved main ways: horizontal gene transfer mutation different genes. The genetic basis developing occurs through four mechanisms: limiting uptake, modification target, inactivation drug, active efflux drug. These mechanisms use remove from bacterial cell prevent entering binding targets. This prevents drugs working effectively, acquire classified phylogenetic groups (A, B1, B2, D1, D2, E, clade I). It very versatile bacterium easily adapt environmental factors. present review gathered information about pathogenicity, antimicrobial resistance, phylogenetics aspects interconnected; thus, it will provide on tracking spread genes using how evolve. Understanding variation help monitoring controlling outbreaks novel treatment. increasing rate ability evolve rapidly, suggest in-depth research needed these areas.

Language: Английский

Citations

0