Mitochondrial Dysfunction in Endothelial Cells: A Key Driver of Organ Disorders and Aging
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 372 - 372
Published: March 21, 2025
Mitochondria
are
of
great
importance
in
cell
biology
since
they
major
sites
adenosine
triphosphate
(ATP)
production
and
widely
involved
different
cellular
pathways
the
response
to
stress.
During
ATP
production,
reactive
oxygen
species
(ROS)
can
be
produced.
While
a
small
amount
ROS
may
important
for
regulation
physiological
processes,
at
elevated
levels
turn
into
harmful
agents
leading
damage.
From
pathological
perspective,
it
could
particularly
interesting
focus
on
mitochondrial
function
endothelial
cells
development
aging
onset
diseases,
including
renal,
cardio-metabolic,
liver
neurodegenerative
ones.
However,
date,
there
no
surveys
which
address
above
issues.
To
fill
this
gap,
valuable
collect
recent
findings
about
role
mitochondria
function,
not
only
increase
knowledge
but
also
clinical
applications.
Here,
we
overview
most
issues
view
characterizing
as
an
innovative
potential
target
prevention
aging,
well
treatment
conditions.
Language: Английский
The Probiotic Yeast, Milmed, Promotes Autophagy and Antioxidant Pathways in BV-2 Microglia Cells and C. elegans
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 393 - 393
Published: March 27, 2025
Background:
Autophagy,
a
catabolic
process
essential
for
maintaining
cellular
homeostasis,
declines
with
age
and
unhealthy
lifestyles,
contributing
to
neurodegenerative
diseases.
Probiotics,
including
Milmed
yeast,
have
demonstrated
anti-inflammatory
antioxidant
properties.
This
study
evaluated
the
activity
of
on
BV-2
microglial
cells
in
vitro
vivo
model
Caenorhabditis
elegans
(C.
elegans)
restoring
autophagic
processes.
Methods:
were
incubated
S.
cerevisiae
(Milmed
treated
yeast
or
untreated
yeast)
then
stimulated
lipopolysaccharide
(LPS).
mRNAs
factors
enzymes
assessed
by
qPCR;
mTOR
NRF2
ELISA.
pNRF2
compared
cytosolic
was
immunofluorescence.
The
longevity,
body
size,
reactive
oxygen
species
(ROS)
levels
C.
measured
fluorescence
microscopy.
Results:
Treatment
YPD
cultured
dried
powder
obtained
from
it
promoted
flux,
as
shown
increased
expression
Beclin-1,
ATG7,
LC3,
p62
inhibition
mTOR,
It
also
enhanced
response
increasing
NRF2,
SOD1,
GPX;
moreover,
enhanced,
dietary
supplementation
prolonged
survival
reduced
age-related
ROS
accumulation
without
changing
gst-4.
pro-longevity
effect
found
be
dependent
SKN-1/Nrf2
activation,
absence
benefit
skn-1
mutants.
Conclusions:
demonstrates
significant
pro-autophagy
effects
elegans,
thereby
extending
lifespan
improving
stress
resistance,
which,
together
previously
activity,
highlights
its
role
highly
effective
probiotic
beneficial
health
effects.
Activation
SKN-1/NRF2
pathway
modulation
autophagy
support
therapeutic
potential
neuroprotection
healthy
aging.
Language: Английский
Ultrasound-assisted extraction combined with enzyme hydrolysis enhanced the anti-aging effects and bioactivity of longan flower, mulberry, and roselle: Phytochemical profiling and in vivo C. elegans validation
Kuo‐Ching Jan,
No information about this author
Mohsen Gavahian
No information about this author
Food Bioscience,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106686 - 106686
Published: April 1, 2025
Language: Английский
Methods for Synthesis and Extraction of Resveratrol from Grapevine: Challenges and Advances in Compound Identification and Analysis
Ramona Căpruciu,
No information about this author
C Gheorghiu
No information about this author
Foods,
Journal Year:
2025,
Volume and Issue:
14(7), P. 1091 - 1091
Published: March 21, 2025
Resveratrol
is
the
most
important
biopotential
phytoalexin
of
stilbene
group
(natural
polyphenolic
secondary
metabolites),
synthesized
naturally
by
action
biotic
and
abiotic
factors
on
plant.
The
yield
individual
bioactive
compounds
isolated
from
grapevine
components,
products
by-products
directly
dependent
conditions
synthesis,
extraction
identification
techniques
used.
Modern
methods
synthesis
extraction,
as
well
techniques,
are
centred
use
non-toxic
solvents
that
have
advantages
realisation
rapid
extractions,
maintenance
optimal
parameters,
low
energy
consumption;
this
a
challenge
with
promising
results
for
various
industrial
applications.
Actionable
advances
in
identifying
analysing
stilbenes
consist
coupling
synthesis/extraction/identification
proven
accurate,
reproducible
efficient.
main
remains
to
keep
resveratrol
compositionally
unaltered
while
increasing
its
microbiome
solubility
stability
nutraceutical
food
industry.
Language: Английский
Investigating the neuroprotective effects of strawberry extract against diesel soot-induced motor dysfunction in Drosophila: an in-vivo and in-silico study
A Ravindranath,
No information about this author
Avula Muralidhar,
No information about this author
Nikki Gambhir
No information about this author
et al.
In Silico Pharmacology,
Journal Year:
2025,
Volume and Issue:
13(2)
Published: April 16, 2025
Language: Английский
From Synaptic Plasticity to Neurodegeneration: BDNF as a Transformative Target in Medicine
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4271 - 4271
Published: April 30, 2025
The
brain-derived
neurotrophic
factor
(BDNF)
has
become
one
of
the
cornerstones
neuropathology,
influencing
synaptic
plasticity,
cognitive
resilience,
and
neuronal
survival.
Apart
from
its
molecular
biology,
BDNF
is
a
powerful
target
for
transformative
benefit
in
precision
medicine,
leading
to
innovative
therapeutic
approaches
neurodegenerative
psychiatric
diseases
like
Alzheimer's
disease
(AD),
Parkinson's
(PD),
major
depressive
disorder
(MDD),
post-traumatic
stress
(PTSD).
Nevertheless,
clinical
applicability
obstructed
by
hurdles
delivery,
patient-specific
diversity,
pleiotropic
signaling.
Here,
we
summarize
findings
research,
including
regulatory
pathways
diagnostic/prognostic
biomarkers
integrative
approaches.
We
describe
delivery
systems,
such
as
lipid
nanoparticle-based
mRNA
therapies
CRISPR-dCas9-based
epigenetic
editing
that
bypass
obstacles
BBB
(blood-brain
barrier)
enzymatic
degradation.
recent
implementation
multiplex
panels
combining
biodynamic
indicators
with
tau
amyloid-β
signaling
markers
showcases
novel
levels
specificity
both
early
detection
potential
monitoring.
Humanized
preclinical
models
iPSC-derived
neurons
organoids
point
key
role
neurodeveloping
processes,
paralleling
advances
bridging
observation
environments.
Moreover,
tools
delivering
TrkB
activators
or
AI-based
dynamic
care
platforms
enable
tailored
scalable
treatments.
This
review
also
aims
extend
framework
used
understanding
BDNF's
relevance
traditional
situating
more
work
detailing
actions
ischemic
tissues
gut-brain
axis
context
systemic
health.
Finally,
outline
roadmap
incorporation
BDNF-centered
into
worldwide
healthcare,
highlighting
ethical
issues,
equity,
interdisciplinary
decomposition.
heralds
new
era
neuroscience
revolutionizing
brain
health
paving
way
advancement
medicine.
Language: Английский
Green extraction of bioactives from Vitis vinifera L. cv. Tannat pomace and chemical characterization by comprehensive two-dimensional liquid chromatography (LC × LC)
Journal of Chromatography A,
Journal Year:
2025,
Volume and Issue:
unknown, P. 466030 - 466030
Published: May 1, 2025
Language: Английский