The blood-brain barrier in aging and neurodegeneration

Molecular Psychiatry, Год журнала: 2022, Номер 27(6), С. 2659 - 2673

Опубликована: Март 31, 2022

Abstract The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an exquisite control of exchange compounds between the blood and parenchyma. Moreover, BBB prevents unwanted toxins pathogens from entering brain. This barrier, however, breaks down with age further disruption a hallmark many age-related disorders. Several drugs have been explored, thus far, to protect or restore function. With recent connection gut microbiota, microbial-derived metabolites explored their capabilities physiology. review, will focus on components that make up BBB, dissect levels discuss current therapeutics maintain integrity discoveries effects

Язык: Английский

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Mitochondria-containing extracellular vesicles (EV) reduce mouse brain infarct sizes and EV/HSP27 protect ischemic brain endothelial cultures

Journal of Controlled Release, Год журнала: 2023, Номер 354, С. 368 - 393

Опубликована: Янв. 18, 2023

Язык: Английский

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Microglial morphometric analysis: so many options, so little consistency

Frontiers in Neuroinformatics, Год журнала: 2023, Номер 17

Опубликована: Авг. 10, 2023

Quantification of microglial activation through morphometric analysis has long been a staple the neuroimmunologist’s toolkit. Microglial morphological phenomics can be conducted either manual classification or constructing digital skeleton and extracting data from it. Multiple open-access paid software packages are available to generate these skeletons via semi-automated and/or fully automated methods with varying degrees accuracy. Despite advancements in morphometrics (quantitative measures cellular morphology), there limited development tools analyze datasets they generate, particular those containing parameters tens thousands cells analyzed by pipelines. In this review, we compare critique approaches using cluster machine learning driven predictive algorithms that have developed tackle large datasets, propose improvements for methods. particular, highlight need commitment open science groups developing classifiers. Furthermore, call attention communication between strong engineering/computer background neuroimmunologists produce effective analytical simplified operability if see their wide-spread adoption glia biology community.

Язык: Английский

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Precision drug delivery to the central nervous system using engineered nanoparticles

Nature Reviews Materials, Год журнала: 2024, Номер 9(8), С. 567 - 588

Опубликована: Июнь 25, 2024

Язык: Английский

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Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons

Nature Biomedical Engineering, Год журнала: 2024, Номер 8(4), С. 415 - 426

Опубликована: Фев. 19, 2024

Язык: Английский

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The Crucial Role of the Blood–Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 386 - 386

Опубликована: Янв. 9, 2025

The blood-brain barrier (BBB) is a crucial structure that maintains brain homeostasis by regulating the entry of molecules and cells from bloodstream into central nervous system (CNS). Neurodegenerative diseases such as Alzheimer's Parkinson's disease, well ischemic stroke, compromise integrity BBB. This leads to increased permeability infiltration harmful substances, thereby accelerating neurodegeneration. In this review, we explore mechanisms underlying BBB disruption, including oxidative stress, neuroinflammation, vascular dysfunction, loss tight junction integrity, in patients with neurodegenerative diseases. We discuss how breakdown contributes neurotoxicity, abnormal accumulation pathological proteins, all which exacerbate neuronal damage facilitate disease progression. Furthermore, potential therapeutic strategies aimed at preserving or restoring function, anti-inflammatory treatments, antioxidant therapies, approaches enhance integrity. Given role neurodegeneration, maintaining its represents promising approach slow prevent progression

Язык: Английский

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Advanced Nanoparticle Engineering for Precision Therapeutics of Brain Diseases

Biomaterials, Год журнала: 2025, Номер 318, С. 123138 - 123138

Опубликована: Янв. 28, 2025

Язык: Английский

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Blood–Brain Barrier Dysfunction in the Pathogenesis of Major Depressive Disorder

Cellular and Molecular Neurobiology, Год журнала: 2021, Номер 42(8), С. 2571 - 2591

Опубликована: Окт. 12, 2021

Язык: Английский

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The mechanism of ferroptosis regulating oxidative stress in ischemic stroke and the regulation mechanism of natural pharmacological active components

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 154, С. 113611 - 113611

Опубликована: Сен. 5, 2022

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges worldwide due to their high morbidity and mortality limitations in clinical treatment strategies. Studies have shown that reactive oxygen species (ROS)-mediated inflammation, excitotoxicity, programmed cell death of each neurovascular unit during post-stroke hypoxia reperfusion play an important role the pathological cascade. Ferroptosis, a characterized by iron-regulated accumulation lipid peroxidation, is caused abnormal metabolism lipids, glutathione (GSH), iron, can accelerate acute central nervous system injury. Recent studies gradually uncovered process ferroptosis stroke. Some drugs iron chelators, ferrostatin-1 (Fer-1) liproxstatin-1 (Lip-1) protect nerves after injury stroke inhibiting ferroptosis. In addition, combined with our previous on mediated natural compounds this review summarized progress regulation mechanism chemical components herbal recent years, order provide reference information for future research lead development inhibitors.

Язык: Английский

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Utility of Exosomes in Ischemic and Hemorrhagic Stroke Diagnosis and Treatment

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(15), С. 8367 - 8367

Опубликована: Июль 28, 2022

Stroke is the leading cause of death and neurological disorders worldwide. However, diagnostic techniques treatments for stroke patients are still limited certain types stroke. Intensive research has been conducted so far to find suitable treatments, but there no success. In recent years, various studies have drawn much attention clinical value utilizing mechanism exosomes, low toxicity, biodegradability, ability cross blood–brain barrier. Recent reported on use biomarkers protective recovery effects exosomes derived from stem cells or in stage after This review focuses publications describing changes following strokes processes potential applications as therapeutics.

Язык: Английский

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