Çukurova medical journal (Online)/Çukurova medical journal,
Год журнала:
2022,
Номер
47(3), С. 1073 - 1079
Опубликована: Сен. 20, 2022
Purpose:
The
aim
of
this
study
is
to
see
oxidative
DNA
damage
(8-OHdG),
its
relationship
with
inflammatory
mediators
(IL6
and
TNFA),
reflections
on
laboratory
findings
in
patients
who
had
COVID-19
infection
at
different
intensities.
Materials
Methods:
Serum
interleukin-6
(IL6),
tumor
necrosis
factor-alpha
(TNFA),
8-hydroxy-2′-deoxyguanosine
(8-OHdG)
levels
were
measured
using
kits
based
the
enzyme-linked
immunosorbent
assay
(ELISA)
principle.
Results:
In
positive
treated
intensive
care
8-OHdG
marker
level
highest
statistically
significant.
receiving
inpatient
treatment
hospitalized,
higher
than
control
outpatient
groups.
IL6
values
patient
group
unit
There
was
no
significant
difference
between
groups
terms
TNFA
values.
Neutrophil-to-lymphocyte
ratio
(NLR)
lower
all
C-reactive
protein
(CRP)
hospitalized
group.
Lactate
dehydrogenase
(LDH)
found
be
significantly
outpatients.
Conclusion:
As
severity
increases,
serum
also
increase.
These
parameters
can
guide
diagnosis
early
stages
disease
course.
The
coronavirus
disease
2019
(COVID-19),
caused
by
severe
acute
respiratory
syndrome
2
(SARS-CoV-2),
has
presented
global
challenges
with
a
diverse
clinical
spectrum,
including
complications
and
systemic
effects.
This
review
explores
the
intricate
relationship
between
mitochondrial
dysfunction,
aging,
obesity
in
COVID-19.
Mitochondria
are
vital
for
cellular
energy
provision
resilience
against
age-related
macromolecule
damage
accumulation.
They
manage
allocation
cells,
activating
adaptive
responses
stress
signals
such
as
redox
imbalance
innate
immunity
activation.
As
organisms
age,
function
diminishes.
Aging
obesity,
linked
to
compromise
antiviral
response,
affecting
release
of
interferons,
worsening
COVID-19
severity.
Furthermore,
development
post-acute
sequelae
SARS-CoV-2
infection
(PASC),
also
known
long
COVID
been
associated
altered
metabolism,
chronic
immune
dysregulation
derived
from
dysfunction.
Understanding
interplay
mitochondria,
viral
infections
provides
insights
into
pathogenesis.
Targeting
health
may
offer
potential
therapeutic
strategies
mitigate
outcomes
address
long-term
consequences
infected
individuals.
Biomedicines,
Год журнала:
2022,
Номер
10(11), С. 2854 - 2854
Опубликована: Ноя. 8, 2022
Although
recent
data
highlight
the
greater
protective
effects
exerted
by
Membrane
Blue
Dual
(MBD),
a
precise
analysis
of
mechanisms
action
is
missing.
We
examined
MBD
with/without
polyethylene
glycol
(PEG)
on
both
human
retinal
pigment
epithelial
cells
(ARPE-19)
and
ganglion
cells-like
(RGC-5)
cultured
in
presence/absence
ultraviolet
B
(UVB)
treatment
mitochondria
function,
oxidants,
apoptosis.
In
ARPE-19/RGC-5
either
treated
or
not
with
UVB,
PEG
were
evaluated
specific
assays
for
viability,
mitochondrial
membrane
potential
reactive
oxygen
species
(mitoROS)
release.
Annexin
V
was
used
to
detect
apoptosis,
whereas
trypan
blue
scratch
assay
proliferation/migration.
physiologic
conditions
presence
increased
cell
potential,
proliferation
migration
ARPE-19
RGC-5
cells.
general,
than
those
caused
without
PEG.
Our
results
suggest
that,
particular,
safe
effective
dye
vitreoretinal
surgery
through
modulation
function.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Апрель 19, 2023
Abstract
Silent
hypoxemia,
or
‘happy
hypoxia’,
is
a
puzzling
phenomenon
in
which
patients
who
have
contracted
COVID-19
exhibit
very
low
oxygen
saturation
(SaO
2
<
80%)
but
do
not
experience
discomfort
breathing.
The
mechanism
by
this
blunted
response
to
hypoxia
occurs
unknown.
We
previously
shown
that
computational
model
(Diekman
et
al.,
2017,
J.
Neurophysiol)
of
the
respiratory
neural
network
can
be
used
test
hypotheses
focused
on
changes
chemosensory
inputs
central
pattern
generator
(CPG).
hypothesize
altered
function
at
level
carotid
bodies
and/or
nucleus
tractus
solitarii
are
responsible
for
hypoxia.
Here,
we
use
our
explore
hypothesis
altering
properties
gain
representing
sensing
CPG.
then
vary
other
parameters
and
show
carrying
capacity
most
salient
factor
producing
silent
hypoxemia.
call
clinicians
measure
hematocrit
as
clinical
index
physiology
infection.
Çukurova medical journal (Online)/Çukurova medical journal,
Год журнала:
2022,
Номер
47(3), С. 1073 - 1079
Опубликована: Сен. 20, 2022
Purpose:
The
aim
of
this
study
is
to
see
oxidative
DNA
damage
(8-OHdG),
its
relationship
with
inflammatory
mediators
(IL6
and
TNFA),
reflections
on
laboratory
findings
in
patients
who
had
COVID-19
infection
at
different
intensities.
Materials
Methods:
Serum
interleukin-6
(IL6),
tumor
necrosis
factor-alpha
(TNFA),
8-hydroxy-2′-deoxyguanosine
(8-OHdG)
levels
were
measured
using
kits
based
the
enzyme-linked
immunosorbent
assay
(ELISA)
principle.
Results:
In
positive
treated
intensive
care
8-OHdG
marker
level
highest
statistically
significant.
receiving
inpatient
treatment
hospitalized,
higher
than
control
outpatient
groups.
IL6
values
patient
group
unit
There
was
no
significant
difference
between
groups
terms
TNFA
values.
Neutrophil-to-lymphocyte
ratio
(NLR)
lower
all
C-reactive
protein
(CRP)
hospitalized
group.
Lactate
dehydrogenase
(LDH)
found
be
significantly
outpatients.
Conclusion:
As
severity
increases,
serum
also
increase.
These
parameters
can
guide
diagnosis
early
stages
disease
course.
