Structural characterization of a polysaccharide from Alhagi honey and its protective effect against inflammatory bowel disease by modulating gut microbiota dysbiosis

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 259, С. 128937 - 128937

Опубликована: Дек. 23, 2023

Язык: Английский

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A Versatile Intestine‐on‐Chip System for Deciphering the Immunopathogenesis of Inflammatory Bowel Disease

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(7)

Опубликована: Янв. 23, 2024

Abstract The multifactorial nature of inflammatory bowel disease (IBD) necessitates reliable and practical experimental models to elucidate its etiology pathogenesis. To model the intestinal microenvironment at onset IBD in vitro, it is important incorporate relevant cellular noncellular components before inducing stepwise pathogenic developments. A novel intestine‐on‐chip system for investigating multiple aspects IBD's immunopathogenesis presented. includes an array tight polarized barrier formed from epithelial cells on in‐vivo‐like subepithelial matrix within one week. dynamic remodeling by or their secretome demonstrates physiological relevance on‐chip models. design enables introduction various immune cell types stimuli specific locations same model, which facilitates investigations distinct roles each type inflammation development. It showed that behavior manifests upregulated expression markers cytokines (TNF‐α). neutralizing effect anti‐inflammatory antibody Infliximab levels TNF‐α inducible could be explicitly shown. Overall, innovative approach systematically developing a microphysiological comprehend immune‐system‐mediated disorders identify new therapeutic strategies

Язык: Английский

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Potential effects of nutrition‐induced alteration of gut microbiota on inflammatory bowel disease: A review

Journal of Digestive Diseases, Год журнала: 2024, Номер 25(2), С. 78 - 90

Опубликована: Фев. 1, 2024

Inflammatory bowel disease (IBD), mainly comprising ulcerative colitis and Crohn's disease, is a group of gradually progressive diseases bringing significant mental anguish imposes serious economic burdens. Interplay genetic, environmental, immunological factors have been implicated in its pathogenesis. Nutrients, as crucial environmental determinants, encompassing carbohydrates, fats, proteins, micronutrients, are closely related to the pathogenesis development IBD. Nutrition essential for maintaining dynamic balance intestinal eco‐environments ensure barrier immune homeostasis, while this can be disrupted easily by maladjusted nutrition. Research has firmly established that nutrition potential shape composition function gut microbiota affect course. Unhealthy diet eating disorders lead dysbiosis further destroy such disruption membrane integrity increased permeability, thereby triggering inflammation. Notably, appropriate nutritional interventions, Mediterranean diet, positively modulate microecology, which may provide promising strategy future IBD prevention. In review, we insights into interplay between effects on present some previously overlooked lines evidence regarding role derived metabolites processes, trimethylamine N‐oxide imidazole propionate. Furthermore, reducing risk onset exacerbation modifying discuss several outstanding challenges opportunities study.

Язык: Английский

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Interplay between Microbiota and γδ T Cells: Insights into Immune Homeostasis and Neuro-Immune Interactions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1747 - 1747

Опубликована: Фев. 1, 2024

The gastrointestinal (GI) tract of multicellular organisms, especially mammals, harbors a symbiotic commensal microbiota with diverse microorganisms including bacteria, fungi, viruses, and other microbial eukaryotic species. This exerts an important role on intestinal function contributes to host health. microbiota, while benefiting from nourishing environment, is involved in the development, metabolism immunity host, contributing maintenance homeostasis GI tract. immune system orchestrates key features host–microbe symbiosis via unique immunological network that populates wall different cell populations. Intestinal epithelium contains lymphocytes intraepithelial (IEL) space between tight junctions basal membrane gut epithelium. IELs are mostly CD8+ T cells, great majority them expressing CD8αα homodimer, γδ receptor (TCR) instead αβ TCR expressed conventional cells. cells play significant surveillance tissue maintenance. review provides overview how regulates influence microbiota-derived metabolites responses, highlighting their impact homeostasis. It also discusses neuro-immune regulation possess ability interact both brain.

Язык: Английский

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Activation of free fatty acid receptors, FFAR1 and FFAR4, ameliorates ulcerative colitis by promote fatty acid metabolism and mediate macrophage polarization

International Immunopharmacology, Год журнала: 2024, Номер 130, С. 111778 - 111778

Опубликована: Март 1, 2024

Язык: Английский

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