Separations,
Год журнала:
2022,
Номер
9(3), С. 73 - 73
Опубликована: Март 11, 2022
Copper
ions
bind
to
biomolecules
(e.g.,
peptides
and
proteins)
playing
an
essential
role
in
many
biological
physiological
pathways
the
human
body.
The
resulting
complexes
may
contribute
initiation
of
neurodegenerative
diseases,
cancer,
bacterial
viral
or
act
as
therapeutics.
Some
compounds
can
chemically
damage
macromolecules
initiate
development
pathogenic
states.
Conversely,
a
number
these
have
antibacterial,
antiviral,
even
anticancer
properties.
One
most
significant
current
discussions
Cu
biochemistry
relates
mechanisms
positive
negative
actions
based
on
generation
reactive
oxygen
species,
including
radicals
that
interact
with
DNA
molecules.
This
review
aims
analyze
various
peptide–copper
mechanism
their
action.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2023,
Номер
43(2_suppl), С. 95 - 105
Опубликована: Фев. 21, 2023
Methylene
Blue
(MB)
is
a
brain-penetrating
drug
with
putative
neuroprotective,
antioxidant
and
metabolic
enhancing
effects.
In
vitro
studies
suggest
that
MB
enhances
mitochondrial
complexes
activity.
However,
no
study
has
directly
assessed
the
effects
of
in
human
brain.
We
used
vivo
neuroimaging
to
measure
effect
on
cerebral
blood
flow
(CBF)
brain
metabolism
humans
rats.
Two
doses
(0.5
1
mg/kg
humans;
2
4
rats;
iv)
induced
reductions
global
(F(1.74,
12.17)5.82,
p
=
0.02)
rats
(F(1,5)26.04,
0.0038).
Human
rate
oxygen
(CMRO2)
was
also
significantly
reduced
(F(1.26,
8.84)8.01,
0.016),
as
rat
glucose
(CMRglu)
(t
2.6(16)
0.018).
This
contrary
our
hypothesis
will
increase
CBF
energy
metrics.
Nevertheless,
results
were
reproducible
across
species
dose
dependent.
One
possible
explanation
concentrations
used,
although
clinically
relevant,
reflect
MB's
hormetic
effects,
i.e.,
higher
produce
inhibitory
rather
than
augmentation
metabolism.
Additionally,
here
we
healthy
volunteers
normal
where
ability
enhance
might
be
limited.
Journal of Alzheimer s Disease,
Год журнала:
2024,
Номер
98(2), С. 387 - 401
Опубликована: Фев. 23, 2024
Alzheimer's
disease
(AD)
affects
more
than
40
million
people
worldwide
and
is
the
leading
cause
of
dementia.
This
a
challenge
for
both
patients
caregivers
puts
significant
strain
on
global
healthcare
system.
To
address
this
issue,
Lancet
Commission
recommends
focusing
reducing
modifiable
lifestyle
risk
factors
such
as
hypertension,
diabetes,
physical
inactivity.
Passive
pulsatile
shear
stress
(PPSS)
interventions,
which
use
devices
like
whole-body
periodic
acceleration,
acceleration
along
Z-axis
(pGz),
Jogging
Device,
have
shown
systemic
cellular
effects
in
preclinical
clinical
models
these
risks
factors.
Based
this,
we
propose
that
PPSS
could
be
potential
non-pharmacological
non-invasive
preventive
or
therapeutic
strategy
AD.
We
perform
comprehensive
review
biological
basis
based
all
publications
using
demonstrate
their
various
aspects
draw
from
analysis
to
support
our
hypothesis.
then
delve
into
possible
application
an
innovative
intervention.
discuss
how
holds
promise
ameliorating
hypertension
diabetes
while
mitigating
inactivity,
potentially
offering
holistic
approach
AD
prevention
management.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11000 - 11000
Опубликована: Окт. 12, 2024
Bioassembly
encompasses
various
techniques
such
as
bioprinting,
microfluidics,
organoids,
and
self-assembly,
enabling
advances
in
tissue
engineering
regenerative
medicine.
Advancements
bioassembly
technologies
have
enabled
the
precise
arrangement
integration
of
cell
types
to
more
closely
mimic
complexity
functionality
neurovascular
unit
(NVU)
that
other
biodiverse
multicellular
structures.
In
this
context,
bioprinting
offers
ability
deposit
cells
a
spatially
controlled
manner,
facilitating
construction
interconnected
networks.
Scaffold-based
assembly
strategies
provide
structural
support
guidance
cues
for
growth,
formation
complex
bio-constructs.
Self-assembly
approaches
utilize
inherent
properties
drive
spontaneous
organization
interaction
neuronal
vascular
components.
However,
recreating
intricate
microarchitecture
functional
characteristics
tissue/organ
poses
additional
challenges.
materials
hold
great
promise
addressing
these
The
further
refinement
technologies,
improved
resolution
incorporation
multiple
types,
can
enhance
accuracy
biological
constructs;
however,
developing
bioinks
growth
cells,
viability,
while
maintaining
compatibility
with
process
remains
an
unmet
need
field,
advancements
design
bioactive
biodegradable
scaffolds
will
aid
controlling
adhesion,
differentiation,
vascularization
within
engineered
tissue.
Additionally,
integrating
advanced
imaging
analytical
real-time
monitoring
characterization
bioassembly,
aiding
quality
control
optimization.
While
challenges
remain,
ongoing
research
technological
propel
field
forward,
paving
way
transformative
developments
engineering.
This
work
provides
overview
advancements,
challenges,
future
perspectives
fabricating
constructs
add-on
focus
on
technologies.
Separations,
Год журнала:
2022,
Номер
9(3), С. 73 - 73
Опубликована: Март 11, 2022
Copper
ions
bind
to
biomolecules
(e.g.,
peptides
and
proteins)
playing
an
essential
role
in
many
biological
physiological
pathways
the
human
body.
The
resulting
complexes
may
contribute
initiation
of
neurodegenerative
diseases,
cancer,
bacterial
viral
or
act
as
therapeutics.
Some
compounds
can
chemically
damage
macromolecules
initiate
development
pathogenic
states.
Conversely,
a
number
these
have
antibacterial,
antiviral,
even
anticancer
properties.
One
most
significant
current
discussions
Cu
biochemistry
relates
mechanisms
positive
negative
actions
based
on
generation
reactive
oxygen
species,
including
radicals
that
interact
with
DNA
molecules.
This
review
aims
analyze
various
peptide–copper
mechanism
their
action.
