The multifaceted benefits of walking for healthy aging: from Blue Zones to molecular mechanisms

GeroScience, Год журнала: 2023, Номер 45(6), С. 3211 - 3239

Опубликована: Июль 26, 2023

Abstract Physical activity, including walking, has numerous health benefits in older adults, supported by a plethora of observational and interventional studies. Walking decreases the risk or severity various outcomes such as cardiovascular cerebrovascular diseases, type 2 diabetes mellitus, cognitive impairment dementia, while also improving mental well-being, sleep, longevity. Dose-response relationships for walking duration intensity are established adverse outcomes. Walking’s favorable effects on factors attributed to its impact circulatory, cardiopulmonary, immune function. Meeting current physical activity guidelines briskly 30 min per day 5 days can reduce several age-associated diseases. Additionally, low-intensity exercise, exerts anti-aging helps prevent age-related making it powerful tool promoting healthy aging. This is exemplified lifestyles individuals Blue Zones, regions world with highest concentration centenarians. other activities contribute significantly longevity these regions, being an integral part their daily lives. Thus, incorporating into routines encouraging walking-based interventions be effective strategy aging all populations. The goal this review provide overview vast consistent evidence supporting specific focus discuss outcomes, prevention Furthermore, will delve molecular cellular mechanisms aging, providing insights underlying biological through which beneficial effects.

Язык: Английский

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Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems

Biomedicines, Год журнала: 2022, Номер 10(12), С. 3113 - 3113

Опубликована: Дек. 2, 2022

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as "brain fog", fatigue and clotting problems. Explanations for "long COVID" include immune imbalance, incomplete viral clearance potentially, mitochondrial dysfunction. As conditions sub-optimal function are associated initial severity of disease, their prior health could be key in resistance to long COVID recovery. The SARs virus redirects host metabolism towards replication; response, can metabolically react control virus. Resolution is normally achieved after stress activates a hormetic negative feedback mechanism. It therefore possible that, some individuals function, "tip" into chronic inflammatory cycle. This might explain main including platelet Long thus described virally induced self-perpetuating imbalanced non-resolving state characterised by dysfunction, where reactive oxygen species continually drive inflammation shift glycolysis. would suggest that sufferer's needs "tipped" back using stimulus, physical activity, calorie restriction, or chemical compounds mimic these enhancing perhaps combination inhibitors quell response.

Язык: Английский

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Impact of (long) COVID on athletes’ performance: a prospective study in elite football players

Annals of Medicine, Год журнала: 2023, Номер 55(1)

Опубликована: Апрель 26, 2023

To investigate possible persistent performance deficits after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in elite athletes.A prospective cohort study three Belgian professional male football teams was performed during the 2020 - 2021 season. Participants were submitted to strength, jump, and sprint tests an aerobic test (the Yo-Yo Intermittent Recovery (YYIR)). These repeated at fixed time intervals throughout Assessment of SARS-CoV-2 by a polymerase chain reaction (PCR) before each official game.Of 84 included participants, 22 infected with follow-up. At first testing (52.0 ± 11.2 days positive PCR testing) significantly higher percentages maximal heart rate (%HRmax) seen within isolated group players- (p = .006) YYIR (2 min after, p .013), compared pre-infection data. This increase %HRmax resolved second (127.6 33.1 testing). Additionally, when comparing formerly non-infected athletes, found < .001) .001),No significant for muscular strength or tests.Aerobic seems compromised even weeks infection. Simultaneously, anaerobic seemed be spared. Because potential detrimental effects on immune system, caution might advised high-intensity exposure until is restored.KEY MESSAGESElite players' affected they return sports infection.Similarly, showed no discernible changes between both infections.Regular recommended monitor

Язык: Английский

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Effects of a multi-professional intervention on body composition, physical fitness and biochemical markers in overweight COVID-19 survivors: a clinical trial

Frontiers in Physiology, Год журнала: 2023, Номер 14

Опубликована: Авг. 28, 2023

Introduction: The sequelae post-COVID can affect different systems. In this sense, considering the multi-factorial etiology of COVID-19, multi-professional interventions could be a relevant strategy for recovery health indicators. Objective: This study aimed to investigate effects intervention on body composition, physical fitness, and biomarkers in overweight COVID-19 survivors with symptomatology. Methodology: A non-randomized parallel group included 69 volunteers (BMI ≥25 kg/m2), divided into three groups according SARS CoV-2 symptomatology, but only 35 finished longitudinal protocol [control (n = 11); moderate 17) severe 7)]. were submitted program (nutritional intervention, psychoeducation, exercise intervention) 8 weeks, underwent composition assessments (primary outcome) biochemical tests (secondary pre- post-intervention. was registered Clinical Trials Registration Platform number: RBR-4mxg57b local research ethics committee under 4,546,726/2021. Results: After 8-week following results observed group: improved dynamic strength lower- (p 0.003), upper-limbs 0.008), maximal isometric lumbar-traction 0.04), flexibility 0.0006), albumin 0.0005), as well reduction C reactive protein (CRP) 0.003) fasting glucose 0.001); an improvement lower-body 0.001), higher values 0.005) HDL-c 0.002), lower CRP 0.05), control sit-up repetitions 0.01), 0.001) total cholesterol 0.04) identified. All experimental reduced triglycerides after < 0.05). Conclusion: Finally, weeks multiprofessional efficient tool reversing inflammatory process promoting improvements daily activities quality life, although it is believed that needs longer improve Trial Registration: https://ensaiosclinicos.gov.br/, identifier: RBR-4mxg57b.

Язык: Английский

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Recent Progress in Applicability of Exercise Immunology and Inflammation Research to Sports Nutrition

Nutrients, Год журнала: 2021, Номер 13(12), С. 4299 - 4299

Опубликована: Ноя. 28, 2021

This article focuses on how nutrition may help prevent and/or assist with recovery from the harmful effects of strenuous acute exercise and physical training (decreased immunity, organ injury, inflammation, oxidative stress, fatigue), a focus nutritional supplements. First, ketogenic diets metabolism inflammation are considered. Second, various supplements immune function discussed, including antioxidant defense modulators (vitamin C, sulforaphane, taheebo), reducers (colostrum hyperimmunized milk). Third, 3-hydroxy-3-methyl butyrate monohydrate (HMB) offset muscle damage is reviewed. Fourth finally, relationship between exercise, COVID-19 infection briefly mentioned. While additional verification safety efficacy these still necessary, current evidence suggests that have potential applications for health promotion disease prevention among athletes more diverse populations.

Язык: Английский

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A Systematic Review and Meta-Analysis on Aerobic Fitness Dynamics in Post-COVID-19 Athletes: Implications in the Return-to-Play Performance

Sports, Год журнала: 2025, Номер 13(2), С. 40 - 40

Опубликована: Фев. 5, 2025

Maximal oxygen uptake (V.O2max) assesses athletic performance; however, its values are inconsistent in post-COVID-19 athletes. This study aimed to analyze the dynamics of V.O2max Observational studies were identified by screening PubMed database published up 17 July 2023. The initial electronic search found 320 studies. Of these, 26 employing cardiopulmonary exercise test (CPET) assess aerobic fitness selected. 2625 pooled athletes, 1464 infected and considered as group, either asymptomatic or symptomatic, while remaining 1161, who uninfected had results prior infection, defined infection-free group. Age differently distributed between athletes those without infection (p = 0.03 both). Persistent symptoms 8 mL/Kg/min lower than 0.04). In addition, post-infected underwent CPET after 12 weeks showed a significant reduction 2.9 according increase body mass index (BMI). analysis that was reduced post-COVID-19. negatively correlated with BMI at weeks, suggesting persist beyond affecting return-to-play.

Язык: Английский

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Effect of physical activity on the immune system in the normal state and in various diseases: a review

Bulletin of Rehabilitation Medicine, Год журнала: 2025, Номер 24(1), С. 91 - 102

Опубликована: Фев. 25, 2025

INTRODUCTION. Regular physical exercise has a beneficial effect on health, affecting all body systems and reducing morbidity. Muscle fiber activity during helps reduce levels of inflammatory markers stimulate anti-inflammatory responses. The ability to maintain homeostasis while exercising adaptation exercises depend fitness, comorbidities other factors, so the program should be tailored individual. THE MAIN CONTENT OF REVIEW. Immune system activation in response is mediated by cytokine signaling. main source cytokines skeletal muscles themselves. Cytokines produced myocytes (myokines) muscle contraction play key role providing communication between working organs tissues. Numerous studies have shown positive moderate intensity myokine secretion. People with chronic infectious or non-infectious diseases often demonstrate low-grade systemic inflammation low circulating myokines. Moderate effects conditions diseases. Exercise popular non-pharmacological adjunct traditional treatments rehabilitation for many CONCLUSION. Understanding relationship modalities optimize treatment recommendations populations different needs, such as patients cancer, diseases, post-viral infection syndromes.

Язык: Английский

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Association of Physical Activity With SARS-CoV-2 Infection and Severe Clinical Outcomes Among Patients in South Korea

JAMA Network Open, Год журнала: 2023, Номер 6(4), С. e239840 - e239840

Опубликована: Апрель 25, 2023

Importance The association of moderate to vigorous physical activity (MVPA) with COVID-19 outcomes is unclear and needs be investigated. Objective To identify the longitudinal changes in MVPA SARS-CoV-2 infection severe outcomes. Design, Setting, Participants This nested case-control study used data from 6 396 500 adult patients South Korean who participated National Health Insurance Service (NHIS) biennial health screenings period 1 (2017-2018) 2 (2019-2020). Patients were followed October 8, 2020, until diagnosis or December 31, 2021. Exposure Moderate was measured by self-report on questionnaires during both NHIS calculated adding frequency (times per week) each (≥30 minutes day) (≥20 activity. Main Outcomes Measures main a positive clinical events. Adjusted odds ratio (aORs) 99% CIs using multivariable logistic regression analysis. Results A total 183 350 (mean [SD] age, 51.9 [13.8] years; female, 89 369 [48.7%]; male, 93 981 [51.3%]) among 110 268 participants identified. For vs without COVID-19, proportion at 35.8% 35.9% for physically inactive, 18.9% times week, 17.7% 3 4 27.5% 27.4% 5 more week. Among unvaccinated, inactive 1, increased when engaged week (aOR, 1.08; CI, 1.01-1.15), 1.09; 1.03-1.16), 1.10; 1.04-1.17) 2. Conversely, unvaccinated decreased 0.90; 0.81-0.98) 0.80; 0.73-0.87) trend incident mitigated fully vaccinated. Furthermore, showed significant but limited associations MVPA. Conclusions Relevance findings this show direct risk infection, which after completion vaccination primary series. In addition, higher levels associated lower proportions.

Язык: Английский

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Alterations in Circadian Rhythms, Sleep, and Physical Activity in COVID-19: Mechanisms, Interventions, and Lessons for the Future

Molecular Neurobiology, Год журнала: 2024, Номер 61(12), С. 10115 - 10137

Опубликована: Май 3, 2024

Язык: Английский

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Role of the renin-angiotensin system in NETosis in the coronavirus disease 2019 (COVID-19)

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 148, С. 112718 - 112718

Опубликована: Фев. 13, 2022

Myocardial infarction and stroke are the leading causes of death in world. Numerous evidence has confirmed that hypertension promotes thrombosis induces myocardial stroke. Recent findings reveal neutrophil extracellular traps (NETs) involved induction Meanwhile, patients with severe COVID-19 suffer from complications such as pathological signs NETs. Due to extremely low amount virus detected blood remote organs (e.g., heart, brain kidney) a few cases, it is difficult explain mechanism by which triggers NETosis, there may be different than lung. A large number studies have found renin-angiotensin system regulates NETosis at multiple levels COVID-19, endocytosis SARS-COV-2, abnormal angiotensin II levels, activation procoagulant function contribute formation reticular structure thrombosis. The treatment angiotensin-converting enzyme inhibitors (ACEI), type 1 receptor blockers (ARBs) recruitment active antagonists helps regulate pressure reduce risk net review will explore possible role NETs COVID-19.

Язык: Английский

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