Gerontology and Geriatric Medicine,
Год журнала:
2024,
Номер
10
Опубликована: Янв. 1, 2024
In
this
study,
based
on
the
2022
National
Health
and
Aging
Trend
Study
(
N
=
5,593,
age
65+),
we
examined
direct
associations
between
moderate
vigorous
physical
exercise
(PE)
depressive/anxiety
symptoms
as
well
bothersome
pain
sleep
problems.
We
then
if
association
PE
would
be
partially
mediated
by
effects
of
Results
from
a
path
model
showed
that
controlling
for
sociodemographic
health
statuses,
was
negatively
associated
with
pain,
but
it
not
significantly
The
mediation
analysis
10%
total
indirect
pain.
This
study
is
important
among
PE,
sleep,
depression/anxiety
in
community-dwelling
older
adults
their
natural
environments.
Healthcare
social
service
providers
need
to
emphasize
importance
benefits
adults’
mental
health.
Easy
access
venues
also
important.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Сен. 14, 2023
Abstract
Background
Biological
ageing
is
tightly
linked
to
cardiovascular
disease
(CVD).
We
aimed
investigate
the
relationship
between
Life’s
Essential
8
(LE8),
a
currently
updated
measure
of
health
(CVH),
and
biological
ageing.
Methods
This
cross-sectional
study
selected
adults
≥
20
years
age
from
2005–2010
National
Health
Nutrition
Examination
Survey.
LE8
scores
(range
0–100)
were
obtained
measurements
based
on
American
Heart
Association
definitions,
divided
into
behavior
factor
scores.
was
assessed
by
different
methods
including
phenotypic
age,
acceleration
(PhenoAgeAccel),
(BioAgeAccel).
Correlations
analyzed
weighted
linear
regression
restricted
cubic
spline
models.
Results
Of
11,729
participants
included,
mean
47.41
±
0.36
5983
(51.01%)
female.
The
ages
42.96
0.41
46.75
0.39
years,
respectively,
score
67.71
0.35.
After
adjusting
for
potential
confounders,
higher
associated
with
lower
PhenoAgeAccel,
BioAgeAccel,
nonlinear
dose–response
relationships.
Negative
associations
also
found
ageing,
stronger
factors.
In
factor-specific
analyses,
β
negativity
greater
blood
glucose
pressure.
inverse
correlations
in
stratified
analyses
remained
solid
across
strata.
Conclusions
its
subscale
strongly
negatively
related
Encouraging
optimal
CVH
levels
may
be
advantageous
preventing
slowing
down
Nutrients,
Год журнала:
2023,
Номер
15(24), С. 5116 - 5116
Опубликована: Дек. 15, 2023
Cognitive
impairment
and
dementia
are
burgeoning
public
health
concerns,
especially
given
the
increasing
longevity
of
global
population.
These
conditions
not
only
affect
quality
life
individuals
their
families,
but
also
pose
significant
economic
burdens
on
healthcare
systems.
In
this
context,
our
comprehensive
narrative
review
critically
examines
role
nutritional
supplements
in
mitigating
cognitive
decline.
Amidst
growing
interest
non-pharmacological
interventions
for
enhancement,
delves
into
efficacy
vitamins,
minerals,
antioxidants,
other
dietary
supplements.
Through
a
systematic
evaluation
randomized
controlled
trials,
observational
studies,
meta-analysis,
focuses
outcomes
such
as
memory
attention
improvement,
executive
function
support,
neuroprotection.
The
findings
suggest
complex
interplay
between
supplementation
health,
with
some
showing
promising
results
others
displaying
limited
or
context-dependent
effectiveness.
highlights
importance
dosage,
bioavailability,
individual
differences
response
to
supplementation.
Additionally,
it
addresses
safety
concerns
potential
interactions
conventional
treatments.
By
providing
clear
overview
current
scientific
knowledge,
aims
guide
professionals
researchers
making
informed
decisions
about
use
health.
Nutrients,
Год журнала:
2024,
Номер
16(5), С. 729 - 729
Опубликована: Март 2, 2024
Longevity
is
rightly
considered
one
of
the
greatest
achievements
modern
society,
not
only
as
a
function
lifespan,
but,
more
importantly,
healthspan.
There
are
Blue
Zones
(LBZs),
regions
around
world,
such
in
Okinawa,
Japan;
Nicoya
Peninsula,
Costa
Rica;
Loma
Linda,
California;
Icaria,
Greece;
and
Ogliastra,
Sardinia,
that
characterized
by
significant
percentage
residents
who
live
exceptionally
long
lives,
often
avoiding
age-related
disability
to
significantly
higher
degree
than
Western
way
life.
universal
phenomenon,
so
if
there
places
world
with
characteristics
similar
LBZs,
it
important
identify
them
order
better
understand
what
other
factors,
addition
known
ones,
might
contribute
healthy
This
narrative
review
aims
common
factors
between
Cilento
five
taking
into
account
environmental,
nutritional,
lifestyle
factors.
Articles
from
2004
present,
limited
studies
published
English,
German,
Italian,
were
searched
PubMed/Medline,
Scopus,
Google
Scholar.
The
co-authors
agreed
on
18
final
reference
texts.
In
evaluate
similarities
descriptive
comparative
approach
was
used.
LBZs
share
several
including
hilly
altitude
ranging
355
600
m;
mild
climate
throughout
year,
temperatures
17.4
23.5
degrees
Celsius;
traditional
professions,
agriculture
animal
husbandry;
predominantly
Mediterranean
or
plant-based
diet,
typical
recipes
based
legumes,
tubers,
vegetables,
extra
virgin
olive
oil.
Additionally,
maintenance
strong
intergenerational
family
relationships,
religious
devotion,
social
relationships
within
community
also
prevalent.
Given
Cilento,
wonder
this
an
LBZ
waiting
be
discovered.
lessons
learned
discovery
could
applied
general
population
protect
non-communicable
chronic
diseases
help
slow
aging
process.
Abstract
Europe
is
experiencing
a
significant
demographic
shift,
with
aging
populations
posing
economic
and
social
challenges
due
to
increased
healthcare
costs
higher
prevalence
of
age-related
diseases.
Hungary,
in
particular,
faces
these
acutely
morbidity
mortality
rates
from
range
chronic
diseases
behavioral
risk
factors.
Addressing
issues
requires
innovative
approaches
promote
healthy
aging.
Semmelweis
University,
the
largest
provider
leading
health
sciences
university
region,
developing
comprehensive
program.
A
critical
pillar
this
program
Semmelweis-EUniWell
Workplace
Health
Promotion
Model
Program,
pioneering
initiative
aimed
at
tackling
unhealthy
within
Hungary’s
workforce
by
leveraging
workplace
as
platform
for
promotion.
Central
program’s
goal
combating
sedentary
lifestyles—a
contributor
issues—is
use
micro-gyms
motivational
interviewing.
Micro-gyms,
their
compact
size
accessibility,
provide
convenient
exercise
opportunities,
while
interviewing
fosters
intrinsic
motivation
personalized
counseling
encourage
sustained
physical
activity.
Through
concerted
efforts
approaches,
including
implementation
micro-gyms,
Program
aims
set
benchmark
promotion,
fostering
healthier
more
resilient
population
Hungary.
This
not
only
enhances
well-being
employees
University
its
EUniWell
partner
institutions
but
also
catalyzes
broader
transformations
promotion
nationwide.
Expert Review of Cardiovascular Therapy,
Год журнала:
2024,
Номер
22(1-3), С. 91 - 101
Опубликована: Март 3, 2024
The
evidence
supporting
the
cardiovascular
health
benefits
of
physical
activity
and/or
exercise
training
is
well-established.
While
role
in
primary
prevention
unequivocal,
its
significance
secondary
(among
those
with
preexisting
disease)
less
definitive.
Though
guidelines
universally
recommend
as
part
preventive
strategy,
empirical
underpinning
these
recommendations
not
robust
that
for
prevention.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(13), С. 7411 - 7411
Опубликована: Июль 5, 2024
Advancing
age
is
associated
with
several
age-related
diseases
(ARDs),
musculoskeletal
conditions
impacting
millions
of
elderly
people
worldwide.
With
orthopedic
contributing
towards
considerable
number
patients,
a
deeper
understanding
bone
aging
the
need
hour.
One
underlying
factors
cellular
senescence
and
its
secretory
phenotype
(SASP).
SASP
comprises
pro-inflammatory
markers,
cytokines
chemokines
that
arrest
cell
growth
development.
The
accumulation
over
years
leads
to
chronic
low-grade
inflammation
advancing
age,
also
known
as
inflammaging.
pathways
molecular
mechanisms
focused
on
inflammaging
are
currently
limited
but
increasingly
being
explored.
Most
genes,
involved
in
coincide
those
cancer
other
ARDs
like
osteoarthritis
(OA).
Thus,
exploring
these
using
techniques
sequencing,
identifying
combatting
them
most
suitable
approach
crucial
for
healthy
early
detection
ARDs.
Several
approaches
can
be
used
aid
regeneration
reduce
bone.
These
may
pharmacological,
non-pharmacological
lifestyle
interventions.
increasing
evidence
intricate
relationship
between
aging,
senescence,
ARDs,
anti-aging
strategies
marrow
(BM).
The Journal of Prevention of Alzheimer s Disease,
Год журнала:
2025,
Номер
12(3), С. 100039 - 100039
Опубликована: Янв. 9, 2025
Physical
inactivity
is
one
of
the
most
important
modifiable
risk
factors
for
Alzheimer's
disease
in
North
America.
Despite
this,
older
adults
are
physically
inactive.
It
currently
unknown
how
to
successfully
motivate
physical
activity
behavior
at
disease,
and
this
knowledge
crucial
early
effective
prevention.
Prior
research
has
shown
that
intergenerational
social
engagement
prosocial
behaviours
can
enhance
health
well-being
adults.
This
manuscript
describes
design
a
randomized
controlled
trial
will
test
efficacy
behavioral
intervention
disease.
single-blinded,
two-arm
stratified
incorporates
hybrid
implementation
design.
Participants
an
or
control
condition
1:1
ratio
by
multimodal
score.
All
study
visits
conducted
remotely
through
videoconferencing.
The
aims
recruit
60
with
first-degree
family
history
from
PREVENT-AD
cohort
30
younger
who
paired
condition.
Older
participants
group
be
partners
receive
positive,
daily
messages
over
four
weeks
using
novel
technology
platform.
combine
(growing
virtual
garden
partner)
goals
(donations
charity
after
reaching
step
count
goals).
primary
outcome
change
compared
baseline
measured
wrist-worn
triaxial
accelerometer.
Secondary
outcomes
include
time
spent
active,
mood,
generativity,
loneliness,
cognition.
Target
mechanisms
(social
support
generativity)
examined.
Ease
use,
acceptability,
feasibility
as
well
barriers
facilitators
participation
assessed.
advance
our
understanding
individual
differences
underlying
successful
contribute
strategies
promoting
prevent
