International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(21), С. 12889 - 12889
Опубликована: Окт. 25, 2022
Recent
advances
in
glioblastoma
(GB)
research
have
shed
light
on
the
molecular
characteristics,
defected
intracellular
signaling
pathways,
and
genetic
epigenetic
alterations
involved
their
pathogenesis.
Despite
constant
efforts,
GB
remains
an
aggressive
malignant
tumor
with
limited
therapeutic
approaches,
poor
prognosis,
a
low
survival
rate.
Emerging
evidence
points
towards
crucial
impact
of
post-translational
modifications
cancer
development
emphasis
regulatory
role
histone
deacetylation
several
key
cellular
processes,
including
metabolic
regulation
stress
response,
senescence,
proliferation,
DNA
repair,
apoptosis.
The
silent
information
regulator
proteins
(Sirtuins)
are
deacetylases
non-histone
that
been
recently
implicated
initiation
as
well
progression
GB.
Herein,
we
provide
critical
overview
emerging
functional
mechanism
action
seven
Sirtuins
(SIRT1-7)
discuss
potential
targeting
options
clinical
practice.
Biomolecules,
Год журнала:
2022,
Номер
12(6), С. 824 - 824
Опубликована: Июнь 13, 2022
Nonalcoholic
fatty
liver
disease
(NAFLD),
recently
renamed
metabolic-associated
(MAFLD),
is
one
of
the
most
common
causes
diseases
worldwide.
NAFLD
growing
in
parallel
with
obesity
epidemic.
No
pharmacological
treatment
available
to
treat
NAFLD,
specifically.
The
reason
might
be
that
a
multi-factorial
an
incomplete
understanding
mechanisms
involved,
absence
accurate
and
inexpensive
imaging
tools,
lack
adequate
non-invasive
biomarkers.
consists
accumulation
excess
lipids
liver,
causing
lipotoxicity
progress
steatohepatitis
(NASH),
fibrosis,
hepatocellular
carcinoma.
for
pathogenesis
current
interventions
management
disease,
role
sirtuins
as
potential
targets
are
discussed
here.
In
addition,
diagnostic
non-coding
RNAs
emerging
biomarkers
summarized.
availability
biomarkers,
diagnosis
tools
crucial
detection
early
signs
progression
NAFLD.
This
will
expedite
clinical
trials
validation
therapeutic
treatments.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июль 28, 2023
Metabolic
dysfunction-associated
fatty
liver
disease
(MAFLD)
is
among
the
most
widespread
metabolic
globally,
and
its
associated
complications
including
insulin
resistance
diabetes
have
become
threatening
conditions
for
human
health.
Previous
studies
on
non-alcoholic
(NAFLD)
were
focused
liver's
lipid
metabolism.
However,
growing
evidence
suggests
that
mitochondrial
metabolism
involved
in
pathogenesis
of
NAFLD
to
varying
degrees
several
ways,
instance
cellular
division,
oxidative
stress,
autophagy,
quality
control.
Ultimately,
function
gradually
declines
as
a
result
dysfunction.
The
unable
transfer
excess
droplets
outside
liver.
Therefore,
how
regulate
hepatic
treat
has
focus
current
research.
This
review
provides
details
about
intrinsic
link
with
mechanisms
by
which
dysfunctions
contribute
progression.
Given
crucial
role
progression,
application
potential
multiple
improvement
modalities
(including
physical
exercise,
diabetic
medications,
small
molecule
agonists
targeting
Sirt3,
mitochondria-specific
antioxidants)
treatment
was
evaluated
hoping
provide
new
insights
into
treatment.
Future Medicinal Chemistry,
Год журнала:
2022,
Номер
14(12), С. 915 - 939
Опубликована: Май 18, 2022
Sirtuins
are
NAD+-dependent
protein
lysine
deacylase
and
mono-ADP
ribosylases
present
in
both
prokaryotes
eukaryotes.
The
sirtuin
family
comprises
seven
isoforms
mammals,
each
possessing
different
subcellular
localization
biological
functions.
have
received
increasing
attention
the
past
two
decades
given
their
pivotal
functions
a
variety
of
contexts,
including
cytodifferentiation,
transcriptional
regulation,
cell
cycle
progression,
apoptosis,
inflammation,
metabolism,
neurological
cardiovascular
physiology
cancer.
Consequently,
modulation
activity
has
been
regarded
as
promising
therapeutic
option
for
many
pathologies.
In
this
review,
we
provide
an
up-to-date
overview
biology
pharmacology.
We
examine
main
features
most
relevant
inhibitors
activators,
analyzing
structure-activity
relationships,
applications
biology,
potential.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(20), С. 15160 - 15160
Опубликована: Окт. 13, 2023
Endothelial
cells
(ECs)
form
the
inner
linings
of
blood
vessels,
and
are
directly
exposed
to
endogenous
hazard
signals
metabolites
in
circulatory
system.
The
senescence
death
ECs
not
only
adverse
outcomes,
but
also
causal
contributors
endothelial
dysfunction,
an
early
risk
marker
atherosclerosis.
pathophysiological
process
EC
involves
both
structural
functional
changes
has
been
linked
various
factors,
including
oxidative
stress,
dysregulated
cell
cycle,
hyperuricemia,
vascular
inflammation,
aberrant
metabolite
sensing
signaling.
Multiple
forms
have
documented
atherosclerosis,
autophagic
death,
apoptosis,
pyroptosis,
NETosis,
necroptosis,
ferroptosis.
Despite
this,
molecular
mechanisms
underlying
or
atherogenesis
fully
understood.
To
provide
a
comprehensive
update
on
subject,
this
review
examines
historic
latest
findings
alterations
associated
with
different
stages
Phytotherapy Research,
Год журнала:
2024,
Номер
38(5), С. 2361 - 2387
Опубликована: Март 1, 2024
Abstract
As
the
global
population
ages,
preventing
lifestyle‐
and
aging‐related
diseases
is
increasing,
necessitating
search
for
safe
affordable
therapeutic
interventions.
Among
nutraceuticals,
quercetin,
a
flavonoid
ubiquitously
present
in
various
plants,
has
garnered
considerable
interest.
This
review
aimed
to
collate
analyze
existing
literature
on
potentials
of
especially
its
interactions
with
SIRTs
clinical
applicability
based
bioavailability
safety.
narrative
was
survey
spanning
from
2015
2023
using
PUBMED.
The
keywords
MeSH
terms
used
were:
“quercetin”
AND
“bioavailability”
OR
“metabolism”
“metabolites”
as
well
“SIRTuin”
“SIRT*”
“cellular
effects”
“pathway”
“signaling”
“neuroprotective”
“cardioprotective”
“nephroprotective”
“antiatherosclerosis”
“diabetes”
“antidiabetic”
“dyslipidemia”
“mice”
“rats”.
Quercetin
demonstrates
multiple
activities,
including
neuroprotective,
cardioprotective,
anti‐atherosclerotic
effects.
Its
antioxidant,
anti‐inflammatory,
antiviral,
immunomodulatory
properties
are
well‐established.
At
molecular
level,
it
majorly
interacts
SIRTs,
particularly
SIRT1
SIRT6,
modulates
numerous
signaling
pathways,
contributing
These
pathways
play
roles
reducing
oxidative
stress,
inflammation,
autophagy
regulation,
mitochondrial
biogenesis,
glucose
utilization,
fatty
acid
oxidation,
genome
stability.
However,
trials
quercetin's
effectiveness
humans
scarce.
exhibits
wide
range
SIRT‐mediated
Despite
compelling
preclinical
data,
more
standardized
needed
fully
understand
potential.
Future
research
should
focus
addressing
safety
concerns.
Journal of the European Academy of Dermatology and Venereology,
Год журнала:
2024,
Номер
38(S4), С. 5 - 14
Опубликована: Июнь 17, 2024
Abstract
Senescence
and
epigenetic
alterations
are
two
important
hallmarks
of
cellular
aging.
During
aging,
cells
subjected
to
stress
undergo
many
cycles
damage
repair
before
finally
entering
either
apoptosis
or
senescence,
a
permanent
state
cell
cycle
arrest.
The
first
biomarkers
senescence
be
identified
were
increased
ß‐galactosidase
activity
induction
p16
INK4a
.
Another
feature
senescent
is
the
senescence‐associated
secretory
phenotype
(SASP),
complex
secretome
containing
more
than
80
pro‐inflammatory
factors
including
metalloproteinases,
growth
factors,
chemokines
cytokines.
regulated
through
dynamic
process
involving
self‐amplifying
autocrine
feedback
loop
activation
immune
system.
Senescent
play
positive
negative
roles
depending
on
composition
their
SASP
may
participate
in
various
processes
wound
healing
tumour
suppression,
as
well
regeneration,
embryogenesis,
tumorigenesis,
inflammation
also
biomarker
age,
biological
aging
age‐related
diseases.
Recent
advances
anti‐age
research
have
shown
that
can
now
prevented
delayed
by
clearing
mitigating
effects
which
achieved
healthy
lifestyle
(exercise
diet),
senolytics
senomorphics,
respectively.
An
alternative
tissue
rejuvenation,
stimulating
aged
stem
reprogramming
deprogrammed
cells.
These
non‐clinical
findings
will
open
up
new
avenues
clinical
into
development
treatments
capable
preventing
treating
pathologies
humans.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(8), С. 6749 - 6768
Опубликована: Апрель 4, 2024
Cardiovascular
diseases
(CVDs)
persist
as
the
predominant
cause
of
mortality,
urging
exploration
innovative
pharmaceuticals.
Mitochondrial
dysfunction
stands
a
pivotal
contributor
to
CVDs
development.
Sirtuin
3
(SIRT3),
prominent
mitochondrial
deacetylase
known
for
its
crucial
role
in
protecting
mitochondria
against
damage
and
dysfunction,
has
emerged
promising
therapeutic
target
treatment.
Utilizing
isosteviol,
natural
