Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Фев. 24, 2023
Abstract
Excessive
neural
synchronization
of
populations
in
the
beta
(
β
)
frequency
range
(12-35Hz)
is
intimately
related
to
symptoms
hypokinesia
Parkinson's
disease
(PD).
Studies
have
shown
that
delayed
feedback
strategies
can
interrupt
excessive
and
thus
effectively
alleviate
associated
with
PD
dyskinesia.
Work
on
optimizing
algorithms
continues
progress,
yet
it
remains
challenging
further
improve
inhibitory
effect
reduced
energy
expenditure.
Therefore,
we
first
established
a
mass
model
cortex-basal
ganglia-thalamus-pedunculopontine
nucleus
(BGCTh-PPN)
closed-loop
system,
which
reflect
internal
properties
cortical
basal
ganglia
neurons
their
intrinsic
connections
thalamic
pedunculopontine
neurons.
Second,
effects
three
schemes
based
external
globus
pallidum
(GPe)
oscillations
were
investigated
separately
compared
those
subthalamic
(STN)
only.
Our
results
show
all
four
achieve
effective
suppression
pathological
when
using
linear
algorithm.
The
comparison
revealed
GPe-based
delay
able
greater
oscillation
consumption,
improving
control
performance
effectively,
suggesting
they
may
be
more
for
relief
motor
practical
applications.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Авг. 17, 2022
Dopamine
and
its
receptors
are
currently
recognized
targets
for
the
treatment
of
several
neuropsychiatric
disorders,
including
Parkinson’s
disease,
schizophrenia,
some
drug
use
addictions,
as
well
depression.
widely
distributed
in
various
regions
brain,
but
their
role
exact
contribution
to
diseases
has
not
yet
been
thoroughly
studied.
Based
on
types
dopamine
distribution
different
brain
regions,
this
paper
reviews
current
research
status
molecular,
cellular
circuit
mechanisms
involved
Multiple
lines
investigation
these
provide
a
new
future
direction
understanding
etiology
depression
potential
antidepressant
treatments.
PLoS Computational Biology,
Год журнала:
2023,
Номер
19(2), С. e1010853 - e1010853
Опубликована: Фев. 1, 2023
The
synaptic
organization
of
the
brain
is
constantly
modified
by
activity-dependent
plasticity.
In
several
neurological
disorders,
abnormal
neuronal
activity
and
pathological
connectivity
may
significantly
impair
normal
function.
Reorganization
circuits
therapeutic
stimulation
has
potential
to
restore
dynamics.
Increasing
evidence
suggests
that
temporal
pattern
crucially
determines
long-lasting
effects
stimulation.
Here,
we
tested
whether
a
specific
can
enable
suppression
pathologically
strong
inter-population
through
spike-timing-dependent
plasticity
(STDP).
More
specifically,
how
introducing
time
shift
between
stimuli
delivered
two
interacting
populations
neurons
effectively
decouple
them.
To
end,
first
used
tractable
model,
i.e.,
bidirectionally
coupled
leaky
integrate-and-fire
(LIF)
neurons,
theoretically
analyze
optimal
range
frequency
for
decoupling.
We
then
extended
our
results
reciprocally
connected
(modules)
where
delayed
connections
were
STDP.
As
predicted
theoretical
results,
appropriately
time-shifted
causes
decoupling
two-module
system
STDP,
unlearning
interactions
populations.
Based
on
overall
topology
connections,
modules,
in
turn,
desynchronization
outlasts
cessation
Decoupling
be
realized
burst
as
well
continuous
simulation.
Our
provide
insight
into
further
optimization
variety
multichannel
protocols
aiming
at
reshaping
diseased
networks.
Frontiers in Cellular Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Март 14, 2024
Neural
interactions
in
the
brain
are
affected
by
transmission
delays
which
may
critically
alter
signal
propagation
across
different
regions
both
normal
and
pathological
conditions.
The
effect
of
interaction
on
dynamics
generic
neural
networks
has
been
extensively
studied
theoretical
computational
models.
However,
role
development
oscillatory
basal
ganglia
(BG)
Parkinson's
disease
(PD)
is
overlooked.
Physical Review Research,
Год журнала:
2025,
Номер
7(2)
Опубликована: Май 9, 2025
Aberrant
oscillatory
activity
is
a
hallmark
of
several
brain
disorders
including
Parkinson's
disease
(PD).
Specifically,
interactions
between
neurons
the
subthalamic
nucleus
(STN)
and
globus
pallidus
externus
(GPe)
may
contribute
to
emergence
maintenance
overly
synchronized
beta-band
(15–30
Hz)
oscillations
be
associated
with
motor
symptoms
PD.
Excessive
beta
synchrony
can
mitigated
by
pharmacological
intervention
deep
stimulation
(DBS).
Alternatively,
strategies
that
aim
selectively
modulate
interpopulation
connections
have
therapeutic
potential.
Here,
we
tested
computationally
whether
dual
targeting
STN
GPe
time-shifted
pathologically
strong
synapses
through
inhibitory
spike-timing-dependent
plasticity.
More
specifically,
examined
how
paired
stimuli
delivered
lead
synaptic
rewiring.
To
end,
first
theoretically
analyzed
optimal
range
time
shift
frequency
for
effective
Then,
as
minimal
model
generating
in
healthy
PD
conditions,
considered
STN-GPe
loop
biologically
inspired
parameters.
Time-shifted
modified
long-lasting
This
ultimately
caused
desynchronizing
aftereffects,
resulting
reduced
coupling
network
restoration
dynamics.
Our
findings
demonstrate
critical
role
neuroplasticity
shaping
effects
optimization
variety
multisite
paradigms
aimed
at
reshaping
dysfunctional
networks
Published
American
Physical
Society
2025
Frontiers in Human Neuroscience,
Год журнала:
2023,
Номер
16
Опубликована: Янв. 26, 2023
Introduction
Parkinson's
disease
(PD)
is
a
movement
disorder
characterized
by
the
pathological
beta
band
(15–30
Hz)
neural
oscillations
within
basal
ganglia
(BG).
It
shown
that
suppression
of
abnormal
correlated
with
improvement
PD
motor
symptoms,
which
goal
standard
therapies
including
deep
brain
stimulation
(DBS).
To
overcome
stimulation-induced
side
effects
and
inefficiencies
conventional
DBS
(cDBS)
to
reduce
administered
current,
closed-loop
adaptive
(aDBS)
techniques
were
developed.
In
this
method,
frequency
and/or
amplitude
are
modulated
based
on
various
biomarkers.
Methods
Here,
computational
modeling
cortico-BG-thalamic
network
in
normal
conditions,
we
show
aDBS
subthalamic
nucleus
(STN)
modulation
leads
more
effective
parkinsonian
BG.
Results
Our
results
restored
their
range
reliability
response
thalamic
neurons
cortex
commands
retained
due
modulation.
Furthermore,
notably
less
current
during
compared
cDBS
control
STN
local
field
potential
(LFP)
activity.
Discussion
Efficient
models
may
contribute
clinical
development
optimized
designed
patients
while
leading
better
therapeutic
outcome.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 10, 2023
Parkinson’s
disease
(PD)
is
a
neurodegenerative
characterized
by
motor
and
cognitive
impairments.
The
progressive
depletion
of
dopamine
(DA)
the
pathological
basis
dysfunctional
goal-directed
habitual
control
circuits
in
basal
ganglia.
Exercise-induced
neuroplasticity
could
delay
progression
improving
performance
patients
with
PD.
This
paper
reviews
research
progress
on
motor-cognitive
ganglia
circuit
summarizes
current
hypotheses
for
explaining
exercise
intervention
rehabilitation
Studies
mediated
mechanisms
will
contribute
to
understanding
networks
that
regulate
behaviors
deficits
PD,
facilitating
development
strategies
treatment
Frontiers in Human Neuroscience,
Год журнала:
2023,
Номер
17
Опубликована: Сен. 22, 2023
Introduction
Evidence
suggests
that
spontaneous
beta
band
(11–35
Hz)
oscillations
in
the
basal
ganglia
thalamocortical
(BGTC)
circuit
are
linked
to
Parkinson’s
disease
(PD)
pathophysiology.
Previous
studies
on
neural
responses
motor
cortex
evoked
by
electrical
stimulation
subthalamic
nucleus
have
suggested
resonance
may
underlie
generation
of
and
stimulation-evoked
PD.
Whether
these
stimulation-evoked,
resonant
present
across
PD
patients
internal
segment
globus
pallidus
(GPi),
a
primary
output
BGTC
circuit,
is
yet
be
determined.
Methods
We
characterized
local
field
potentials
(LFPs)
GPi
four
(five
hemispheres)
using
deep
brain
(DBS)
leads
externalized
after
DBS
implantation
surgery.
Results
Our
analyses
show
low-frequency
(2–4
long-latency
(>50
ms)
beta-band
4/5
hemispheres.
demonstrated
sources
generating
both
were
correlated
their
frequency
content
spatial
localization.
Discussion
results
support
hypothesis
same
neuronal
population
phenomenon
generates
pallidal
oscillations.
These
data
also
development
closed-loop
control
systems
modulate
responses.
