Contribution of the delta-class glutathione S-transferase to agrochemical adaptation in Apis mellifera DOI
Timothy W. Moural, Sonu Koirala B K, Gaurab Bhattarai

и другие.

Опубликована: Июль 23, 2023

Abstract The European honey bee, Apis mellifera , serves as the principle managed pollinator species globally. In recent decades, bee populations have been facing serious health threats from combined biotic and abiotic stressors, including diseases, limited nutrition, agrochemical exposure. Understanding molecular mechanisms underlying xenobiotic adaptation of A. is critical, considering its extensive exposure to phytochemicals agrochemicals present in flowers, propolis, hives, environment. this study, we conducted a comprehensive structural functional characterization AmGSTD1, delta class glutathione S-transferase (GST) enzyme, unravel roles detoxification antioxidative stress responses. Significantly, determined 3D structure GST using protein crystallography for first time, providing new insights into structure. Our investigations revealed that AmGSTD1 efficiently metabolizes model substrates, 1-chloro-2,4-dinitrobenzene (CDNB), p-nitrophenyl acetate (PNA), phenylethyl isothiocyanate (PEITC), propyl (PITC), oxidation byproduct 4-hydroxynonenal (4-HNE). Moreover, discovered exhibits binding affinity with fluorophore 8-Anilinonaphthalene-1-sulfonic acid (ANS), which can be inhibited various herbicides, fungicides, insecticides, their metabolites. These findings highlight potential contribution safeguarding against metabolites, while also mitigating oxidative resulting these substances.

Язык: Английский

Early larval exposure to flumethrin induces long-term impacts on survival and memory behaviors of adult worker bees Apis mellifera DOI

Jingliang Shi,

Chen Liu,

Yonghong Zhang

и другие.

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 201, С. 105909 - 105909

Опубликована: Апрель 10, 2024

Язык: Английский

Процитировано

5
Lethal, Sublethal, and Offspring Effects of Fluralaner and Dinotefuran on Three Species of Bactrocera Fruit Flies DOI Creative Commons
Doudou Li, Xinyan Cai, Yi‐xiang Qi

и другие.

Insects, Год журнала: 2024, Номер 15(6), С. 440 - 440

Опубликована: Июнь 11, 2024

Fruit flies cause substantial economic damage, and their management relies primarily on chemical insecticides. However, pesticide resistance has been reported in several fruit fly species, the mitigation of which is crucial to enhancing control. Here, we assess toxicity a novel insecticide (fluralaner) common (dinotefuran) against three Bactrocera dorsalis (Hendel), cucurbitae (Coquillett), tau (Walker). Both pesticides exhibit robust lethal sublethal effects all with fluralaner being more potent. Fluralaner dinotefuran suppress reproductive capacities survival rates flies. at 50% concentration, stimulates capacity B. rate tau. also causes significant transgenerational effects, impacting offspring hatching reducing proportion female offspring. Thus, both high potential for controlling application should be tailored according species variations diverse they may induce. Collectively, findings this study outline two insecticides flies, helping optimize ensure effective resistance.

Язык: Английский

Процитировано

4
The sterol biosynthesis inhibiting fungicide difenoconazole can reduce the impact of the neonicotinoid acetamiprid on honeybee behavior DOI Creative Commons

Antonia Schuhmann,

Mireille Marx,

Ricarda Scheiner

и другие.

Heliyon, Год журнала: 2025, Номер 11(6), С. e43023 - e43023

Опубликована: Фев. 27, 2025

Язык: Английский

Процитировано

0
Olfactory dysfunction induced by pesticides: Adverse outcomes, emerging mechanisms, and risk for neurodegenerative diseases DOI
Lin Wang, Si‐Yang Liu, Han Zheng

и другие.

Pesticide Biochemistry and Physiology, Год журнала: 2025, Номер 213, С. 106474 - 106474

Опубликована: Май 25, 2025

Язык: Английский

Процитировано

0
Architecture and potential roles of a delta-class glutathione S-transferase in protecting honey bee from agrochemicals DOI Creative Commons
Timothy W. Moural, Sonu Koirala B K, Gaurab Bhattarai

и другие.

Chemosphere, Год журнала: 2023, Номер 350, С. 141089 - 141089

Опубликована: Дек. 30, 2023

Язык: Английский

Процитировано

7
Pesticides and pollinator brain: How do neonicotinoids affect the central nervous system of bees? DOI Creative Commons
Marco Paoli, Martín Giurfa

European Journal of Neuroscience, Год журнала: 2024, Номер 60(8), С. 5927 - 5948

Опубликована: Сен. 11, 2024

Abstract Neonicotinoids represent over a quarter of the global pesticide market. Research on their environmental impact has revealed adverse effect cognitive functions pollinators, in particular bees. Cognitive impairments, mostly by behavioural studies, are phenotypic expression an alteration underlying neural circuits, matter deserving greater attention. Here, we reviewed studies field‐relevant doses neonicotinoids neurophysiology and neurodevelopment In particular, focus olfactory system as much knowledge been gained different brain areas that participate odour processing. Recent have detrimental effects at multiple levels system, including modulation odorant‐induced activity sensory neurons, diminished responses antennal lobe (the first processing centre) abnormal development connectivity within mushroom bodies (central neuropils involved multisensory integration, learning memory storage, among others). Given importance perception for aspects bee biology, reported disruption circuit, which can occur even upon exposure to sublethal neonicotinoids, severe consequences both individual colony levels. Moreover, multimodal structure such indicate neonicotinoids' translates other domains. Assessing pesticides is crucial understanding how influence behaviour ecological contexts defining effective sustainable agricultural practices.

Язык: Английский

Процитировано

2
Novel neonicotinoid insecticide cycloxaprid exhibits sublethal toxicity to honeybee (Apis mellifera L.) workers by disturbing olfactory sensitivity and energy metabolism DOI
Weidong Zhang, Zhiyang Jiang, Meng Ding

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 485, С. 136923 - 136923

Опубликована: Дек. 17, 2024

Язык: Английский

Процитировано

2
Neonicotinoid pesticide applications affect pollinator abundance and visitation, leading to implications for sunflower production ( Helianthus annuus L.) DOI Creative Commons
Muhammad Shoaib Saleem,

Muhammad Faheem Akbar,

Muhammad Atif Javed

и другие.

Cogent Food & Agriculture, Год журнала: 2023, Номер 9(1)

Опубликована: Сен. 28, 2023

Pesticides are considered a risk to pollinators; however, little is known about the possible effects of their injudicious use on pollinators, including ecosystem services provided crops and wildflowers. Recently, great attention has been paid neonicotinoids pesticides pollinators potential role in harming health bees all over world. Sunflowers, being self-incompatible plants, rely insects, primarily bees, for effective cross-pollination successful seed-set. Ensuring presence sufficient field crucial facilitating pollen movement between flowers promoting optimal seed development. However, reliance insect-mediated also makes sunflowers susceptible pest attacks, which can negatively impact production. To mitigate these threats achieve increased yields, careful consideration given judicious pesticides. Striking right balance providing adequate implementing appropriate management strategies vital maximizing sunflower crop productivity. reveal such impacts neonicotinoid insecticides, we undergo current study that aimed estimate flower visitation pollination by applying three insecticides i.e. imidacloprid, clothianidin, thiamethoxam, control group two years 2020, 2021. In experimental plots, quantified floral visitors fourteen days at different times (8 am, 12 pm, 5 pm). Floral were divided into groups, Apis Non-Apis butterflies. After maturation period, achenes from each capitulum separated brought weight. We discovered this confirmed adverse effect

Язык: Английский

Процитировано

5
The effects of anthropogenic toxins on honey bee learning: Research trends and significance DOI Creative Commons
Nicole DesJardins, Jon F. Harrison, Brian H. Smith

и другие.

Apidologie, Год журнала: 2023, Номер 54(6)

Опубликована: Ноя. 29, 2023

Abstract Managed honey bees are experiencing high rates of colony loss, in part due to widespread exposure agrochemicals and other environmental toxins. The ability learn about relevant stimuli is an important skill necessary for foraging navigation, although it sometimes impaired that have been exposed toxins or stressors. Here, we review the effects anthropogenic (which divide into five major classes: insecticides, acaricides, biopesticides, agrochemicals, toxins) on learning performance European bees. We discuss general trends these studies, including neurotoxic insecticides overwhelmingly most well-studied, studies focus acute individual, adult a single toxin. Protocols field-relevant vary widely among labs, make suggestions aid standardization future studies. relevance toxicological risk assessment, concluding they valuable tools assessing sublethal behavioral Their inclusion assessment would be improvement over current procedures, which largely lethality.

Язык: Английский

Процитировано

5
Effects of pesticide-adjuvant combinations used in almond orchards on olfactory responses to social signals in honey bees (Apis mellifera) DOI Creative Commons
Wen‐Yen Wu, Ling-Hsiu Liao, Chia‐Hua Lin

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Сен. 20, 2023

Abstract Exposure to agrochemical sprays containing pesticides and tank-mix adjuvants has been implicated in post-bloom mortality, particularly of brood, honey bee colonies brought into California almond orchards for pollination. Although are generally considered be biologically inert, some have exhibited toxicity sublethal effects, including decreasing survival rates next-generation queens. Honey bees a highly developed olfactory system detect discriminate among social signals. To investigate the impact pesticide-adjuvant combinations on signal perception, we performed electroantennography assays assess alterations their responsiveness brood ester pheromone (BEP), volatile larval β-ocimene, alarm 2-heptanone. These aimed uncover potential mechanisms underlying changes behaviors reduced after pesticide exposure. We found that combining adjuvant Dyne-Amic with fungicide Tilt (propiconazole) insecticide Altacor (chlorantraniliprole) synergistically enhanced responses three concentrations BEP as well exerted dampening compensatory effects 2-heptanone respectively. In contrast, exposure alone or combination had no effect at most but altered β-ocimene Dyne-Amic, Altacor, increased amplitude, indicating receptor sensitivity sensilla permeability odorants. Given that, previous study, queens raised by nurses exposed same treated pollen experienced survival, these new findings highlight disruption signaling its implications colony reproductive success.

Язык: Английский

Процитировано

4