Choroid plexus volumes and auditory verbal learning scores are associated with conversion from mild cognitive impairment to Alzheimer's disease

Brain and Behavior, Год журнала: 2024, Номер 14(7)

Опубликована: Июль 1, 2024

Abstract Purpose Mild cognitive impairment (MCI) can be the prodromal phase of Alzheimer's disease (AD) where appropriate intervention might prevent or delay conversion to AD. Given this, there has been increasing interest in using magnetic resonance imaging (MRI) and neuropsychological testing predict from MCI Recent evidence suggests that choroid plexus (ChP), neural substrates implicated brain clearance, undergo volumetric changes Whether ChP is involved memory observed used AD not explored. Method The current study data Disease Neuroimaging Initiative (ADNI) database investigate whether later progression (progressive [pMCI], n = 115) stable (sMCI, 338) was associated with scores Rey Auditory Verbal Learning Test (RAVLT) volumes as calculated MRI. Classification analyses identifying pMCI sMCI group membership were performed compare predictive ability RAVLT volumes. Finding results indicated a significant difference between groups for right volume, showing significantly larger volume ( p .01, 95% confidence interval [−.116, −.015]). A linear relationship found across all participants, but two separately. showed combination left auditory verbal learning resulted most accurate classification performance, accurately predicted 72% data. Conclusion These suggest appear occur before onset provide value predicting

Язык: Английский

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The role of cerebrovascular reactivity on brain activation during a working memory task in type 2 diabetes

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, Год журнала: 2025, Номер 17(1)

Опубликована: Янв. 1, 2025

Abstract INTRODUCTION Impaired cerebrovascular reactivity (CVR) is common in type 2 diabetes (T2D) patients and a risk factor for dementia. However, most prior functional magnetic resonance imaging (fMRI) studies T2D disregarded the impact of impaired CVR on brain activation patterns. This study investigated relationship between during an fMRI task patients. METHODS Seventy‐four underwent working‐memory (WM) task. was measured by breath‐holding index test using transcranial Doppler (TCD). Regression analyses examined associations glycated hemoglobin (HbA1c) with/without adjusting CVR. RESULTS An association found left middle inferior frontal gyri. Adjusting led to different pattern HbA1c‐related activation. DISCUSSION The findings highlight methodological implications, emphasizing importance accounting when analyzing interpreting data Highlights that impacts patterns working memory Accounting altered regions showing related glycemic control. considering vascular factors populations with dysfunction.

Язык: Английский

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Reduced Brain Responsiveness to Emotional Stimuli With Escitalopram But Not Psilocybin Therapy for Depression

American Journal of Psychiatry, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Psilocybin is an emerging intervention for depression that may be at least as effective selective serotonin reuptake inhibitors (SSRIs), but effects of the two treatments on neural correlates emotional processing have never been directly compared. The authors assessed responses to faces using blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) in groups with major depression. One group (N=25; 9 women and 16 men) received dosing sessions 25 mg psilocybin plus 6 weeks daily inert placebo, second (N=21; 15 escitalopram a nonpsychoactive (placebo) dose 1 psilocybin. Both had equal psychological support throughout: 3 hours preparation, one in-person integration session following sessions, further conducted via video call or telephone. An face fMRI paradigm was completed before treatment 6-week posttreatment primary end point (3 sessions). Patient (psilocybin versus escitalopram) interacted time (before after treatment) distributed set cortical regions. Post hoc within-condition analyses showed BOLD all types were significantly reduced group, no change slight increase group. Analyses amygdala responsivity reduction response fearful lesser Despite large improvements depressive symptoms therapy only minor effect brain responsiveness stimuli. These results are consistent prior findings antidepressant action SSRIs often accompanied by responsiveness, this not occur psychedelic therapy.

Язык: Английский

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Neurovascular coupling and functional neuroimaging

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 306 - 324

Опубликована: Авг. 19, 2024

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Functional Brain Changes in Younger Population of Cervical Spondylosis Patients with Chronic Neck Pain

Journal of Pain Research, Год журнала: 2024, Номер Volume 17, С. 4433 - 4445

Опубликована: Дек. 1, 2024

The aim of the research was to observe variations in brain activity between young cervical spondylosis patients with chronic neck pain (CNP) and healthy volunteers resting state investigate central remodeling mechanisms patients.

Язык: Английский

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