Human Reproduction,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 20, 2024
Abstract
The
extensive
use
of
bisphenols
in
the
plastics
industry
globally
is
a
major
growing
concern
for
human
health.
Bisphenol
compounds
are
easily
leached
out
from
plastic
containers
to
food,
beverages,
and
drinking
water
contaminate
natural
environment.
Daily
exposure
bisphenol
increases
their
load
impairs
various
organs,
including
reproductive
system.
directly
or
indirectly
affect
ovarian
functions,
such
as
folliculogenesis,
steroidogenesis,
oogenesis,
thereby
oocyte
quality.
A
(BPA)
its
structural
analogues
act
endocrine
disruptors
induce
generation
reactive
oxygen
species
(ROS)
within
ovary.
Excess
levels
ROS
death
pathways
follicular
steroidogenic
cells
steroidogenesis.
reduced
level
estradiol-17β
growth
development
that
reduces
number
quality
oocytes.
In
addition,
excess
fluid
trigger
meiotic
instability,
which
further
deteriorates
high
generates
oxidative
stress
triggers
germ
well
oocytes,
induces
atresia,
depletes
reserve.
Although
evidence
indicates
destructive
effects
at
ovary,
potential
underlying
mechanisms
deteriorate
remain
poorly
understood.
Therefore,
this
review
summarizes
by
cause
damage
impair
quality,
women's
fertility.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Май 12, 2024
Abstract
Background
Two-dimensional
ultrathin
Ti
3
C
2
(MXene)
nanosheets
have
gained
significant
attention
in
various
biomedical
applications.
Although
previous
studies
described
the
accumulation
and
associated
damage
of
testes
placenta.
However,
it
is
currently
unclear
whether
can
be
translocated
to
ovaries
cause
ovarian
damage,
thereby
impairing
functions.
Results
We
established
a
mouse
model
with
different
doses
(1.25,
2.5,
5
mg/kg
bw/d)
injected
intravenously
for
three
days.
demonstrated
that
enter
were
internalized
by
granulosa
cells,
leading
decrease
number
primary,
secondary
antral
follicles.
Furthermore,
follicles
closely
higher
levels
FSH
LH,
as
well
increased
level
E
P
4
,
decreased
T
ovary.
In
further
studies,
we
found
exposure
toTi
Beclin1,
ATG5,
ratio
LC3II/Ι,
autophagy
activation.
Additionally,
P62
increased,
resulting
autophagic
flux
blockade.
activate
through
PI3K/AKT/mTOR
signaling
pathway,
oxidative
stress
playing
an
important
role
this
process.
Therefore,
chose
cell
line
(KGN
cells)
vitro
validation
impact
on
hormone
secretion
capability.
The
inhibition
initiation
3-Methyladenine
(3-MA)
promoted
smooth
flow,
partially
reduced
estradiol
progesterone
KGN
cells;
Whereas
blocking
Rapamycin
(RAPA)
exacerbated
cells.
Conclusion
nanosheet-induced
hormones
ovary
mediated
activation
impairment
flux,
which
disrupts
normal
follicular
development.
These
results
imply
dysfunction
may
one
underlying
mechanisms
-induced
Our
findings
reveal
mechanism
female
reproductive
toxicity
induced
nanosheets.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
282, С. 116763 - 116763
Опубликована: Июль 23, 2024
There
is
a
close
relationship
between
preconception
health
and
maternal
child
outcomes,
the
consequences
may
be
passed
down
from
generation
to
generation.
In
2018,
Lancet
published
three
consecutive
articles
emphasizing
importance
of
period.
Phthalic
acid
ester
(PAE)
exposure
during
this
period
affect
gametogenesis
epigenetic
information
in
gametophytes,
thereby
affecting
embryonic
development
offspring
health.
Therefore,
article
reviews
effects
parental
PAE
on
reproductive/birth
outcomes
health,
provide
new
evidence
topic.
We
searched
Web
Science,
MEDLINE
(through
PubMed),
China
National
Knowledge
Infrastructure
(CNKI),
ScienceDirect,
VIP
Journal
Library
date
database
establishment
July
3,
2024.
Finally,
12
were
included.
Three
studies
investigated
hazards
(effects
birth
weight,
abortion,
etc.)
women's
exposure.
Nine
involved
both
parents.
considered
impacts
focusing
pregnancy
loss,
preterm
birth,
embryo
quality,
placental
weight.
behavior.
The
results
review
suggested
that
have
an
impact
behavior,
including
dietary
However,
are
relatively
scarce,
current
varied.
It
necessary
use
systematic
verify
accurate
research
question
recommendations
for
public
policy
making.
Environmental Quality Management,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 2, 2024
Abstract
The
reproductive
health
system
holds
paramount
importance
for
human
well‐being.
Reproductive
is
notably
susceptible
to
oxidative
stress,
triggered
by
the
generation
of
reactive
oxygen
species
from
pollutants
such
as
Cd
often
found
in
cigarette
smoke
ultimately
resulting
diminished
fertility
among
couples.
This
review
aims
comprehensively
discuss
repercussions
and
hazards
posed
health,
elucidating
how
pollution
can
instigate
disorders
proposing
mitigation
strategies.
first
set
questions
aimed
avert
pregnancy
abnormalities
curtail
morbidity
mortality
rates
underscores
need
antioxidants
a
pivotal
risk
strategy.
Fostering
public
awareness
healthy
lifestyle
imperative.
These
sustainable
solutions
involvement
expert
organizations
at
local,
national,
global
scales,
employing
multidisciplinary
approach,
are
indispensable
effective
problem‐solving
this
domain.
Findings
highlight
correlation
between
complications,
encompassing
spontaneous
abortions,
premature
deliveries,
low
birth
weight
(LBW),
attributable
pollutants,
thereby
escalating
rates.
<p><strong>The
theca,
a
highly
specialised
stromal
cell
layer
that
surrounds
ovarian
follicles,
first
appears
at
the
secondary
stage
of
follicle
development.
While
role
theca
in
folliculogenesis
is
well
understood,
spatiotemporal
dynamics
governing
differentiation
are
yet
to
be
fully
elucidated.
Spatial
transcriptomics
offers
unique
insight
into
molecular
processes
occur
during
by
capturing
mRNA
expression
patterns
within
tissues,
maintaining
their
spatial
context.
The
overall
objective
this
thesis
was
optimise
protocol
perform
mouse
tissue.
This
contributes
wider
project
which
aims
track
progenitor
differentiated
transition
situ
using
model.
I
refined
protocols
for
collecting
ovaries,
and
various
histological
techniques
(including
freezing,
embedding
cryosectioning)
prioritised
integrity
morphology
tissue
imaging,
while
still
allowing
recovery
high-quality
RNA
from
same
sample.
As
result,
able
validate
preparing
optimised
sample
preparation
protocol,
tissue-specific
permeabilization
optimisation
STOmics
Stereo-seq
Transcriptomics
kit,
contribute
final
transcriptomic
experiment.
prepared
fresh-frozen
block
containing
four
ovaries
mice
(n=4),
sufficient
quality
(RNA
Integrity
Number
(RIN)
7.4
±
0.1)
proceed
with
consistently
passed
all
DNA
concentration
fragment
size
control
checks
throughout
experiment,
indicating
successful
generating
high
(both
terms
quality)
used
prepare
RNA-seq
library.
serves
as
valuable
resource
future
studies
investigate
cellular
ovary.</strong></p>
