Research Progress in Skin Aging and Immunity

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 4101 - 4101

Опубликована: Апрель 7, 2024

Skin aging is a complex process involving structural and functional changes characterized by decrease in collagen content, reduced skin thickness, dryness, the formation of wrinkles. This underpinned multiple mechanisms including free radical theory, inflammation photoaging metabolic theory. The immune system, an indispensable part body’s defense mechanism, comprises macrophages, lymphocytes, dendritic cells, mast cells. These cells play pivotal role maintaining homeostasis responding to injury or infection. As age advances, along with various internal external environmental stimuli, may undergo senescence accelerated aging, cell division capability, increased mortality, gene expression patterns signaling pathways, altered functions. collectively impact overall function system. review summarizes relationship between immunity explores characteristics composition effects these on aging. Immune dysfunction plays significant suggesting that immunoregulation become one important strategies for prevention treatment

Язык: Английский

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Targeting senescent cells to reshape the tumor microenvironment and improve anticancer efficacy

Seminars in Cancer Biology, Год журнала: 2024, Номер 101, С. 58 - 73

Опубликована: Май 27, 2024

Cancer is daunting pathology with remarkable breadth and scope, spanning genetics, epigenetics, proteomics, metalobomics cell biology. Cellular senescence represents a stress-induced essentially irreversible fate associated aging various age-related diseases, including malignancies. Senescent cells are characterized of morphologic alterations metabolic reprogramming, develop highly active secretome termed as the senescence-associated secretory phenotype (SASP). Since first discovery, has been understood an important barrier to tumor progression, its induction in pre-neoplastic limits carcinogenesis. Paradoxically, senescent arising microenvironment (TME) contribute augmented therapeutic resistance. In this article, we define typical forms commonly observed within TME how functionally remodel their surrounding niche, affect immune responses promote cancer evolution. Furthermore, highlight recently emerging pipelines senotherapies particularly senolytics, which can selectively deplete from affected organs vivo impede progression by restoring securing anticancer efficacies. Together, co-targeting normal but counterparts holds potential achieve increased benefits restrained disease relapse future clinical oncology.

Язык: Английский

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Spiny mice (Acomys) have evolved cellular features to support regenerative healing

Annals of the New York Academy of Sciences, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Spiny mice (Acomys spp.) are warm-blooded (homeothermic) vertebrates whose ability to restore missing tissue through regenerative healing has coincided with the evolution of unique cellular and physiological adaptations across different types. This review seeks explore how these bizarre rodents deploy or altered injury response mechanisms either enhance repair fully regenerate excised compared closely related, scar-forming mammals. First, we examine overall trends in Acomys tissues, including stress response, activate maintain cell cycle progression, expression certain features reproductive adults that normally associated embryos. Second, focus on specific types exhibit precisely regulated proliferation tissue. While utilize many same involved scar formation, cells divergent activation profiles during healing. Considered together, current lines evidence support sustained deployment proregenerative pathways conjunction transient fibrotic facilitate regeneration improve Acomys.

Язык: Английский

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Peptide Nanofibers and Skin Regeneration

Advances in experimental medicine and biology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Senescence as a Molecular Target in Skin Aging and Disease

Ageing Research Reviews, Год журнала: 2025, Номер unknown, С. 102686 - 102686

Опубликована: Фев. 1, 2025

Язык: Английский

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Analysis of the senescence secretome during zebrafish retina regeneration

Frontiers in Aging, Год журнала: 2025, Номер 6

Опубликована: Апрель 16, 2025

Introduction Zebrafish possess the innate ability to regenerate any lost or damaged retinal cell type with Müller glia serving as resident stem cells. Recently, we discovered that this process is aided by a population of damage-induced senescent immune As part Senescence Associated Secretory Phenotype (SASP), cells secrete numerous factors can play role in modulation inflammation and remodeling microenvironment during regeneration. However, identity specific SASP drive initiation progression retina regeneration remains unclear. Materials Methods We mined Atlas publicly available RNAseq datasets identify common, differentially expressed after injury. These included two distinct acute damage regimens, well chronic, genetic models degeneration. identified overlapping between these used knockdown experiments, qRT/PCR immunohistochemical staining test for one ( npm1a ). Results an set 31 SASP-related across all data sets paradigms. are upregulated functions span system, autophagic processing, cycle regulation, cellular stress responses. From among these, show depletion Nucleophosmin 1 ) inhibits decreases detection damage. Discussion Our suggest differential expression promotes both chronic The existence provides group novel therapeutic targets studies.

Язык: Английский

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Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach

Aging and Disease, Год журнала: 2024, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2024

Diabetic foot ulcers (DFUs) are a prevalent and profoundly debilitating complication that afflicts individuals with diabetes mellitus (DM). These associated substantial morbidity, recurrence rates, disability, mortality, imposing economic, psychological, medical burdens. Timely detection intervention can mitigate the morbidity disparities linked to DFU. Nevertheless, current therapeutic approaches for DFU continue grapple multifaceted limitations. A growing body of evidence emphasizes crucial role cellular senescence in pathogenesis chronic wounds. Interventions try delay senescence, eliminate senescent cells (SnCs), or suppress senescence-associated secretory phenotype (SASP) have shown promise helping wounds heal. In this context, targeting emerges as novel strategy comprehensive review, we look at pathology treatment systematic way. We also explain importance investigating SnCs highlight great potential senotherapeutics target treatment. The development efficacious safe represents pioneering approach aimed enhancing quality life affected by

Язык: Английский

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Treatment of anal fistulas with Obsidian RFT®: just another autologous compound platelet-rich fibrin foam?

Techniques in Coloproctology, Год журнала: 2024, Номер 28(1)

Опубликована: Авг. 2, 2024

Abstract Background Sphincter-preserving techniques like autologous compound platelet-rich fibrin foam have gained popularity, offering potential for better functional outcomes in anal fistula treatment. The present study aimed to evaluate the efficacy and safety of Obsidian RFT ® . Methods conducted a retrospective analysis from January 2018 December 2022 on patients who received closure with RTF at Department General Surgery, Medical University Vienna. Clinical diagnosis, complemented by radiographic imaging, was employed confirm inconclusive cases. Demographic characteristics postoperative data were collected electronic records following STROCSS criteria. Results Fifteen RFT® treatment fistulas. We found no intra- complications. median hospital stay 3 days. After follow-up 32 months, rate 53.3% detected. Non-significant differences observed various variables, yet trends emerged, indicating associations between abscess presence non-healing A distinct age threshold (≥ 42.7 years) served as an indicator inability achieve cure. Conclusion represents safe, minimally invasive operative procedure. Approximately half experienced healing, outcome younger population. Trial Registration Ethical Approval number Vienna (#1258/2018). This registered retrospectively ClinicalTrials.gov (NCT06136325).

Язык: Английский

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Stem Cells and Nanofibers for Skin Regeneration and Wound Healing

Advances in experimental medicine and biology, Год журнала: 2024, Номер unknown, С. 19 - 30

Опубликована: Янв. 1, 2024

Язык: Английский

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SenMayo transcriptomic senescence panel highlights glial cells in the ageing mouse and human retina

npj Aging, Год журнала: 2024, Номер 10(1)

Опубликована: Ноя. 30, 2024

There is a growing need to better characterise senescent cells in the CNS and retina. The recently published SenMayo gene panel was developed identify transcriptomic signatures of senescence across multiple organ systems, but retina not included. While other approaches have identified retina, these largely focused on experimental models young animals. We therefore conducted detailed single-cell RNA-seq analysis cell populations different aged mice compared with five comprehensive human mouse brain transcriptome datasets. Transcriptomic were most apparent retinal glial cells, IL4, 13 10 AP1 pathway being prominent markers involved. Similar levels transcriptional observed glia old mice, whereas showed significantly increased enrichment scores advancing age.

Язык: Английский

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