Minerva Psychiatry,
Год журнала:
2023,
Номер
64(4)
Опубликована: Дек. 1, 2023
Deep
brain
stimulation
(DBS)
has
received
particular
attention
over
the
past
two
decades
due
to
its
promising
role
in
treatment
of
mental
disorders.
As
DBS
grown
popularity,
ethical
concerns
have
been
raised.
These
are
related,
among
other
issues,
putative
risk
personality
changes
associated
with
treatment,
relatively
unknown
long-term
effects
DBS.,
and
potential
implications
respect
autonomy
free
will.
This
narrative
review
focuses
on
aspects
DBS,
both
current
clinical
use
future
uses.
JAMA Psychiatry,
Год журнала:
2024,
Номер
81(6), С. 611 - 611
Опубликована: Апрель 10, 2024
Interest
in
administering
psychedelic
agents
as
mental
health
treatment
is
growing
rapidly.
As
drugmakers
invest
developing
medicines
for
several
psychiatric
indications,
lawmakers
are
enacting
legal
reforms
to
speed
access
globally,
and
agencies
preparing
approve
these
treatments.
Meanwhile,
US
states,
such
Oregon
Colorado,
making
psychedelics
available
supervised
use
outside
the
conventional
care
system.
Abstract
Background
Psychiatric
neurosurgery
is
experiencing
a
revival.
Beside
deep
brain
stimulation
(DBS),
several
ablative
neurosurgical
procedures
are
currently
in
use.
Each
approach
has
different
profile
of
advantages
and
disadvantages.
However,
many
psychiatrists,
ethicists,
laypeople
sceptical
about
psychiatric
neurosurgery.
Methods
We
identify
the
main
concerns
against
neurosurgery,
discuss
extent
to
which
they
justified
how
might
be
overcome.
review
evidence
for
effectiveness,
efficacy
safety
each
approach,
this
could
improved.
analyse
whether
and,
if
so,
randomised
controlled
trials
(RCTs)
can
used
approaches,
what
alternatives
available
conducting
RCTs
impossible
practical
or
ethical
reasons.
Specifically,
we
problem
failed
after
promising
open-label
studies.
Results
The
are:
(i)
reservations
based
on
historical
psychosurgery,
(ii)
personality
changes,
(iii)
regarding
localised
interventions,
(iv)
scepticism
due
lack
scientific
evidence.
Given
need
effective
therapies
treatment-refractory
disorders
preliminary
effectiveness
further
research
warranted
necessary.
Since
potential
modify
traits,
it
should
held
highest
standards.
Conclusions
with
an
acceptable
risk–benefit
include
DBS
micro-
radiosurgical
anterior
capsulotomy
intractable
obsessive–compulsive
disorder.
These
methods
may
considered
individual
treatment
attempts,
but
multi-centre
necessary
provide
reliable
AJOB Neuroscience,
Год журнала:
2023,
Номер
14(4), С. 418 - 421
Опубликована: Окт. 2, 2023
Click
to
increase
image
sizeClick
decrease
sizeThis
article
refers
to:Translational
Neuroethics:
A
Vision
for
a
More
Integrated,
Inclusive,
and
Impactful
Field
DISCLOSURE
STATEMENTNo
potential
conflict
of
interest
was
reported
by
the
author(s)Additional
informationFundingThis
work
supported
National
Institute
Mental
Health
(R01MH114853).
Expert Review of Neurotherapeutics,
Год журнала:
2024,
Номер
24(7), С. 643 - 659
Опубликована: Май 30, 2024
Introduction
Deep
brain
stimulation
(DBS)
is
an
effective
treatment
for
Parkinson's
disease
(PD)
motor
symptoms
that
improves
function
and
quality
of
life
in
appropriately
selected
patients.
Because
mild
to
moderate
cognitive
declines
can
follow
DBS
impact
a
minority
patients,
important
consideration
involves
the
deficit
its
prediction.
Brain Sciences,
Год журнала:
2022,
Номер
13(1), С. 25 - 25
Опубликована: Дек. 22, 2022
Postoperative
delirium
(POD)
is
associated
with
perioperative
complications
and
mortality.
Data
on
the
risk
factors
for
after
subthalamic
nucleus
deep
brain
stimulation
(STN-DBS)
surgery
not
clarified
in
Parkinson's
disease
(PD)
patients
receiving
total
intravenous
anesthesia.
We
aimed
to
investigate
STN-DBS
PD
patients.The
retrospective
cohort
study
was
conducted,
including
131
who
underwent
first
time
under
anesthesia
from
January
December
2021.
Delirium
assessments
were
performed
twice
daily
7
days
or
until
hospital
discharge
using
confusion
assessment
method
intensive
care
unit.
Multivariate
logistic
regression
analysis
used
determine
factor
of
POD.In
total,
22
(16.8%)
POD
group,
while
other
109
Non-POD
group.
showed
that
preoperative
Mini-mental
State
Examination
score
[odds
ratio
=
0.855,
95%
confidence
interval
0.768-0.951,
p
0.004]
unified
rating
scale
part
3
(on
state)
(odds
1.061,
1.02-1.104,
0.003)
independently
surgery.In
this
patients,
a
lower
higher
independent
International Journal of Translational Medicine,
Год журнала:
2024,
Номер
4(4), С. 608 - 617
Опубликована: Ноя. 10, 2024
Background:
Parkinson’s
disease
(PD)
is
a
common
neurodegenerative
disorder
characterized
by
motor
impairments,
cognitive
decline,
and
affective
changes.
Beyond
the
well-described
symptoms,
neuropsychiatric
symptoms
play
crucial
role
in
PD
disability
burden.
Novelty
seeking,
trait
extensively
studied
within
various
models
of
personality,
may
influence
manifestation
these
non-motor
symptoms.
Methods:
A
narrative
review
articles
determined
relevant
author(s)
was
undertaken.
Results:
The
literature
indicates
that
patients
typically
exhibit
low
novelty
seeking
initially.
However,
dopaminergic
therapies
can
increase
novelty-seeking
behaviors,
sometimes
leading
to
impulse
control
disorders
(ICD).
Studies
using
Temperament
Character
Inventory
(TCI)
suggest
complex
interplay
between
state,
medication,
baseline
which
not
fully
elucidated.
High
scores
predict
higher
risk
ICDs,
yet
they
also
correlate
with
more
benign
clinical
phenotype
improved
quality
life
post-DBS
surgery.
Conclusions:
significant
PD,
influencing
treatment
responses.
Understanding
its
neurobiological
basis
implications
could
lead
better
diagnostic
therapeutic
strategies
through
use
objective,
practical
tools
for
monitoring,
individualized
therapy,
pharmacological
development.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 10, 2024
Abstract
Background
Advances
in
the
development
of
neurotechnologies
have
potential
to
revolutionize
treatment
brain-based
conditions.
However,
a
critical
concern
revolves
around
willingness
public
embrace
these
technologies,
especially
considering
tumultuous
histories
certain
neurosurgical
interventions.
Therefore,
examining
attitudes
is
paramount
uncovering
barriers
adoption
ensuring
ethically
sound
innovation.
Methods
In
present
study,
we
investigate
towards
use
four
(within-subjects
conditions):
deep
brain
stimulation
(DBS),
transcranial
magnetic
(TMS),
pills,
and
MRI-guided
focused
ultrasound
(MRgFUS)
as
treatments
person
experiencing
either
mood,
memory,
or
motor
symptoms
(between-subjects
conditions).
US-based
participants
(N=1052;
stratified
be
nationally
representative
based
on
sex,
race,
age)
were
asked
about
their
perceptions
risk,
benefit,
invasiveness,
acceptability,
perceived
change
person,
personal
interest
using
for
symptom
alleviation.
Results
Descriptive
results
indicate
variability
between
technologies
that
U.S.
willing
consider
if
severe
symptoms.
The
main
effect
neurotechnology
revealed
DBS
was
viewed
most
invasive
risky
lead
greatest
who
someone
person.
also
least
likely
personally
used
acceptable
by
others.
When
effects
symptomatology,
found
all
forms
neuromodulation
significantly
more
beneficial,
acceptable,
symptoms,
followed
memory
lastly
mood
Neuromodulation
(averaging
across
neurotechnologies)
riskier,
invasive,
leading
greater
versus
symptoms;
however,
similarly
with
respect
Conclusion
These
suggest
views
neuromodulatory
approaches
require
surgery
(i.e.,
MRgFUS)
less
than
those
do
not.
Further,
findings
individuals
may
reluctant
alter
treat
psychological
compared
physical
